Cooled antiproton beams of unprecedented intensities in the momentum range of 1.5-15 GeV/c will be used for the PANDA experiment at FAIR to perform high precision experiments in the charmed quark sector. Four major physical research topics will be addressed: Spectroscopy of resonances in the energy region of charmonium and above, In-medium effects of open and hidden charm, glueballs, predicted by QCD, and single and double hypernuclei. The proposed PANDA detector is a 4π internal target spectrometer at the HESR allowing the detection and identification of neutral and charged particles generated within the total energy range of the antiproton annihilation products.