Hydrogen Peroxide and Cysteine Protein Signaling Pathways

Schröder, Ewald; Eaton, Philip

doi:10.1002/9783527627585.ch7

Cited by 5 publications

(2 citation statements)

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“…This highlights the synergistic effect that exists between the H 2 O 2 - and pH-responsive materials composing the dual-NPs, which should translate into greater imaging sensitivity in vivo. In areas of inflammation, activated neutrophils and macrophages can create local extracellular concentrations of H 2 O 2 as high as 100 μM [43], which falls within the sensitive range of these NPs. More modest fluorescence activation was obtained with H 2 O 2 -NPs (Figure S4A).…”

Section: Resultsmentioning

confidence: 99%

Distinct ON/OFF fluorescence signals from dual-responsive activatable nanoprobes allows detection of inflammation with improved contrast

et al. 2017

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Visualization of biochemical changes associated with disease is of great clinical significance, as it should allow earlier, more accurate diagnosis than structural imaging, facilitating timely clinical intervention. Herein, we report combining stimuli-responsive polymers and near-infrared fluorescent dyes (emission max: 790 nm) to create robust activatable fluorescent nanoprobes capable of simultaneously detecting acidosis and oxidative stress associated with inflammatory microenvironments. The spectrally-resolved mechanism of fluorescence activation allows removal of unwanted background signal (up to 20-fold reduction) and isolation of a pure activated signal, which enables sensitive and unambiguous localization of inflamed areas; target-to-background ratios reach 22 as early as 3 h post-injection. This new detection platform could have significant clinical impact in early detection of pathologies, individual tailoring of drug therapy, and image-guided tumor resection.

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Section: Resultsmentioning

confidence: 99%

Distinct ON/OFF fluorescence signals from dual-responsive activatable nanoprobes allows detection of inflammation with improved contrast

et al. 2017

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“…Protein oxidation has been associated with renal damage. The radicals generated on tyrosine could migrate to the cysteine residues, forming a thiyl radical on a local cysteine residue, which can generate a very reactive sulfenic acid; the latter might be converted back to the reduced state or, alternatively, further oxidized, depending on the presence of additional redox active molecules [ 41 ]. The downregulation of protein thiols could be due to intra-protein or inter-protein disulfide formation that affects the protein tridimensional structure and function.…”

Section: Resultsmentioning

confidence: 99%

Structural and Oxidative Changes in the Kidney of Crucian Carp Induced by Silicon-Based Quantum Dots

Petrache

Stanca

Serban³

et al. 2012

IJMS

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Silicon-based quantum dots were intraperitoneally injected in Carassius auratus gibelio specimens and, over one week, the effects on renal tissue were investigated by following their distribution and histological effects, as well as antioxidative system modifications. After three and seven days, detached epithelial cells from the basal lamina, dilated tubules and debris in the lumen of tubules were observed. At day 7, nephrogenesis was noticed. The reduced glutathione (GSH) concentration decreased in the first three days and started to rise later on. The superoxide dismutase (SOD) activity increased only after one week, whereas catalase (CAT) was up-regulated in a time-dependent manner. The activities of glutathione reductase (GR) and glutathione peroxidise (GPX) decreased dramatically by approximately 50% compared to control, whereas the glutathione-S-transferase (GST) and glucose-6-phosphate dehydrogenase (G6PDH) increased significantly after 3 and 7 days of treatment. Oxidative modifications of proteins and the time-dependent increase of Hsp70 expression were also registered. Our data suggest that silicon-based quantum dots induced oxidative stress followed by structural damages. However, renal tissue is capable of restoring its integrity by nephron development.

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Complex Systems Biology of Networks: The Riddle and the Challenge

Aon

2013

Systems Biology of Metabolic and Signaling Networks

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Hydrogen Peroxide and Cysteine Protein Signaling Pathways

Cited by 5 publications

References 98 publications

Distinct ON/OFF fluorescence signals from dual-responsive activatable nanoprobes allows detection of inflammation with improved contrast

Distinct ON/OFF fluorescence signals from dual-responsive activatable nanoprobes allows detection of inflammation with improved contrast

Structural and Oxidative Changes in the Kidney of Crucian Carp Induced by Silicon-Based Quantum Dots

Complex Systems Biology of Networks: The Riddle and the Challenge

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