Hydrogen peroxide and hydroxyl radical mediation of activated neutrophil induced canine myocardial mechanical dysfunction

Hess, M L; Eaton, Laura; Manson, Nancy H.; Rowe, Gilbert T.

doi:10.1016/s0022-2828(86)80559-4

Journal of Molecular and Cellular Cardiology

1986

DOI: 10.1016/s0022-2828(86)80559-4

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Hydrogen peroxide and hydroxyl radical mediation of activated neutrophil induced canine myocardial mechanical dysfunction

M L Hess¹,

Laura Eaton²,

Nancy H. Manson³

et al.

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1995

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Beneficial Effects of Prostacyclin Treatment on Reperfusion of the Myocardium

Ğlu,

Küçükaksu,

Bozdayi

et al. 1995

Cardiovascular Surgery

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A total of 20 patients with coronary artery disease were studied in order to assess the benefits of prostacyclin administration on reperfusion of the ischaemic myocardium after cardiopulmonary bypass. Ten received prostacyclin (25ng/kg per min) while ten were untreated controls. There was no difference between groups with regard to age, preoperative ejection fraction and aortic cross-clamping times. There were no in-hospital deaths in either group. The administration of prostacyclin significantly altered the metabolic side effects of reperfusion followed by hypothermic cardioplegic arrest. Myocardial oxygen consumption after cardiopulmonary bypass was significantly higher in the prostacyclin-treated group than in controls (18.5 ml versus 13 ml; P<0.01). Prostacyclin treatment significantly reduced the leucocyte activity: leukotriene B4 concentrations were 58 pmol/l in prostacyclin-treated patients compared with 93 pmol/l in controls ( P<0.01). Such recovery of metabolic status during reperfusion resulted in better haemodynamic function in patients receiving prostacyclin.

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Beneficial Effects of Prostacyclin Treatment on Reperfusion of the Myocardium

Ğlu,

Küçükaksu,

Bozdayi

et al. 1995

Cardiovascular Surgery

View full text Add to dashboard Cite

show abstract

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Hydrogen peroxide and hydroxyl radical mediation of activated neutrophil induced canine myocardial mechanical dysfunction

Cited by 1 publication

References 0 publications

Beneficial Effects of Prostacyclin Treatment on Reperfusion of the Myocardium

Beneficial Effects of Prostacyclin Treatment on Reperfusion of the Myocardium

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