Hydrogen peroxide decelerates recovery of action potential after high-frequency fatigue in skeletal muscle

Ôba, Toshiharu; Ishikawa, Tatsuya; Takaishi, Tetsuo; Aoki, Takako; Yamaguchi, Mamoru

doi:10.1002/1097-4598(200010)23:10<1515::aid-mus7>3.0.co;2-i

Cited by 8 publications

(3 citation statements)

References 38 publications

(45 reference statements)

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“…H 2 O 2 induces a delay in action potential associated with excitation processes in mouse myoblasts, which was reverted using the antioxidant N-acetylcysteine (NAC) [ 51 ]. Indeed, a decrease in the action potential amplitude was observed in H 2 O 2 -treated fibers after high-frequency stimulation with respect to non-treated fibers [ 52 ]. The addition of H 2 O 2 is known to affect EC coupling, but contradictory information is found in the literature.…”

Section: H 2 O 2 -Mediated Phys...mentioning

confidence: 99%

Energy (and Reactive Oxygen Species Generation) Saving Distribution of Mitochondria for the Activation of ATP Production in Skeletal Muscle

Espinosa,

Casas,

Jaimovich

2023

Antioxidants

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Exercise produces oxidants from a variety of intracellular sources, including NADPH oxidases (NOX) and mitochondria. Exercise-derived reactive oxygen species (ROS) are beneficial, and the amount and location of these ROS is important to avoid muscle damage associated with oxidative stress. We discuss here some of the evidence that involves ROS production associated with skeletal muscle contraction and the potential oxidative stress associated with muscle contraction. We also discuss the potential role of H2O2 produced after NOX activation in the regulation of glucose transport in skeletal muscle. Finally, we propose a model based on evidence for the role of different populations of mitochondria in skeletal muscle in the regulation of ATP production upon exercise. The subsarcolemmal population of mitochondria has the enzymatic and metabolic components to establish a high mitochondrial membrane potential when fissioned at rest but lacks the capacity to produce ATP. Calcium entry into the mitochondria will further increase the metabolic input. Upon exercise, subsarcolemmal mitochondria will fuse to intermyofibrillar mitochondria and will transfer the mitochondria membrane potential to them. These mitochondria are rich in ATP synthase and will subsequentially produce the ATP needed for muscle contraction in long-term exercise. These events will optimize energy use and minimize mitochondria ROS production.

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Section: H 2 O 2 -Mediated Phys...mentioning

confidence: 99%

Energy (and Reactive Oxygen Species Generation) Saving Distribution of Mitochondria for the Activation of ATP Production in Skeletal Muscle

Espinosa,

Casas,

Jaimovich

2023

Antioxidants

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“…The Wushu Sanda movement is developing in a more intense and exciting direction. This puts higher demands on the athlete's physical and psychological qualities, which indirectly increases the incidence of sports injuries [8]. An excellent Sanda athlete should have good physical fitness and special skills.…”

Section: Introductionmentioning

confidence: 99%

Training fatigue and recovery of Wushu Sanda athletes based on comprehensive environmental testing

Ren¹

2023

Applied Mathematics and Nonlinear Sciences

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Wushu Sanda is a practical fighting skill and a new modern competitive event. Under certain conditions, they use kicking, hitting and wrestling as the main means according to certain rules. A good Sanda athlete should have good physical quality and special skills. Given the continuous change and revision of Sanda rules, the means to reduce the number of injuries sustained by athletes, tap their potential and prolong their sports life has become an urgent priority. During the training process, the coaches should use a guided and inspiring educational model to enable athletes to think positively and rationally. It is necessary to clearly understand the physical conditions of the body, combine the special characteristics of the Sanda movement and adopt effective prevention and recovery methods. This paper takes the sports fatigue of Sanda athletes as the research goal. To this end, we use physical, biochemical and psychological indicators and means to comprehensively monitor athletes’ sports fatigue. In order to improve martial arts training, improve the physical health of martial arts athletes and improve the athletes’ competitive level.

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“…H2O2 induces a delay in action potential associated with excitation processes in mouse myoblasts which was reverted using the antioxidant N-acetylcysteine (NAC) [9]. Indeed, a decrease in the action potential amplitude was observed in H2O2-treated fibers after high-frequency stimulation with respect to non-treated fibers [10]. Doses of H2O2 is crucial to affect E-C coupling; but contradictory information is found in literature.…”

Section: Introductionmentioning

confidence: 99%

An Energy-Saving Distribution of Mitochondria Activation of ATP Production in Skeletal Muscle. A Design That Minimizes Mitochondria Ros Production

Espinosa¹,

Casas²,

Jaimovich³

2023

Preprint

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Exercise produces oxidants from a variety of intracellular sources, including NADPH oxidases (NOX) and mitochondria. Exercise-derived ROS are beneficial, and the amount and location of these ROS are important to avoid muscle damage associated with oxidative stress. We discuss here some of the evidence that involves ROS production associated with skeletal muscle contraction and the potential oxidative stress associated with muscle contraction. We also discuss the potential role of H2O2 produced after NOX activation in the regulation of glucose transport in skeletal muscle. Finally, we propose a model based on evidence for the role of different populations of mitochondria in skeletal muscle in the regulation of ATP production upon exercise. The sub-sarcolemmal population of mitochondria has the enzymatic and metabolic components to establish a high mitochondrial membrane potential when fissioned at rest but lacks the capacity to produce ATP; calcium entry to the mitochondria will further increase the metabolic input. Upon exercise, sub-sarcolemmal mitochondria will fuse to intermyofibrillar mitochondria and will transfer the membrane potential to them. These mitochondria are rich in ATP synthase and will subsequentially produce the ATP needed for muscle contraction in long-term exercise. These events will optimize energy use and minimize mitochondria ROS production.

show abstract

Hydrogen peroxide decelerates recovery of action potential after high-frequency fatigue in skeletal muscle

Cited by 8 publications

References 38 publications

Energy (and Reactive Oxygen Species Generation) Saving Distribution of Mitochondria for the Activation of ATP Production in Skeletal Muscle

Energy (and Reactive Oxygen Species Generation) Saving Distribution of Mitochondria for the Activation of ATP Production in Skeletal Muscle

Training fatigue and recovery of Wushu Sanda athletes based on comprehensive environmental testing

An Energy-Saving Distribution of Mitochondria Activation of ATP Production in Skeletal Muscle. A Design That Minimizes Mitochondria Ros Production

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