Hydrogen Peroxide Generation in the Erythrocytes of Newborn Infants

Bracci, Rodolfo; Benedetti, Piero; Ciambellotti, V

doi:10.1159/000240220

Cited by 18 publications

(5 citation statements)

References 10 publications

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“…It is interesting that plas ma from adults inhibited surfactant lipid pe roxidation while plasma from premature in fants not only did not protect against, but on the contrary, induced lipid peroxidation [3], Since the inability of plasma from premature infants to inhibit surfactant lipid peroxida tion was associated with increased plasma free iron content, this paper suggested that increased peroxidation of surfactant lipids follows hydroxyl radical release via the Fen ton reaction. The increased availability of free iron and consequently the predisposition for hydroxyl radical release in the preterm infant are in agreement with previous reports of toxic oxygen species in the red cells of new borns and the increased free iron found in red cells of preterm infants particularly if they are hypoxic in the First hours of life [9,10], Surfactant proteins are also a target for free radicals and can be denatured by reactive oxy gen species. Lung surfactant protein A (SP-A) is an abundant surfactant-associated protein synthesized by type II alveolar cells and Clara cells.…”

supporting

confidence: 91%

Free Oxygen Radicals and Surfactant

Bracci

1997

Neonatology

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supporting

confidence: 91%

Free Oxygen Radicals and Surfactant

Bracci

1997

Neonatology

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“…Human newborns have decreased gluta thione peroxidase activity [10] compared to adults. Our data show is also the situation in the sheep.…”

Section: Discussionmentioning

confidence: 97%

Erythrocyte Enzymes in Sheep: Comparison of Activity in Fetal, Newborn, Maternal and Nonpregnant Ewe Erythrocytes

Noble¹,

Cabalum²,

Nathanielsz³

et al. 1982

Neonatology

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Hematological data and the activities of 21 red cell enzymes were measured in 8 nonpregnant ewes, 13 chronically catheterized fetuses at 125–135 days of gestation, and 8 of their mothers. In addition, 7 lambs were followed from birth to 17 days of age. Fetal sheep red cells have dramatically increased activities for 17 of the 21 enzymes measured compared with adult nonpregnant ewes. The pattern of decline of enzyme activities with development varies considerably among enzymes. The activity of seven enzymes showed an orderly decline from fetal to adult life. For seven enzymes very little or no decline in activity was observed between 125 and 135 days of gestation and birth. Pyruvate kinase activity declined to adult levels by birth. Phosphoglucose isomerase and nucleoside phosphorylase activity increased, and glutathione peroxidase activity decreased in newborn lamb red cells compared to fetal cells. Differences in blood cell variables were also found among these groups.

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“…In the present study, individuals with asthma with severe airflow limitation have a tendency to increased serum glutathione. In vitro studies have shown that exposure to oxidative stress, such as superoxide or H 2 O 2 , causes a transient depletion of glutathione, followed later by prolonged elevation of intracellular glutathione levels (22,51). Further studies are needed to evaluate the relationship of serum glutathione to airway inflammation and oxidative stress.…”

Section: Discussionmentioning

confidence: 99%