Hydrogen Peroxide—Mediated Inhibition of T-Cell Response to Mitogens Is a Result of Direct Action on T Cells

Patterson, Deborah A.; Rapoport, R. I.; Patterson, Mark; Freed, Brian M.; Lempert, Neil

doi:10.1001/archsurg.1988.01400270034004

Cited by 16 publications

(2 citation statements)

References 24 publications

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“…Nevertheless, additional studies have complicated this simple view. Indeed, it has been shown that H 2 O 2 may inhibit and, under particular conditions, also stimulate lymphocyte proliferation (Roth and Droge, 1987;Patterson et al, 1988;Los et al, 1995a). Also, studies from Tsan and colleagues showed that increasing amount of intracellular antioxidants such as glutathione (GSH) increased the proliferation of murine splenic lymphocytes in response to mitogens (Fidelus andTsan, 1986, 1987;.…”

Section: T-cell Activation Is Sensitive To Oxidationmentioning

confidence: 99%

Redox regulation of T-cell receptor signaling

Simeoni

Bogeski

2015

Biological Chemistry

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T-cell receptor (TCR) triggering by antigens activates a sophisticated intracellular signaling network leading to transcriptional activation, proliferation and differentiation of T cells. These events ultimately culminate in adaptive immune responses. Over recent years it has become evident that reactive oxygen species (ROS) play an important role in T-cell activation. It is now clear that ROS are involved in the regulation of T-cell mediated physiological and pathological processes. Upon TCR triggering, T cells produce oxidants, which originate from different cellular sources. In addition, within inflamed tissues, T cells are exposed to exocrine ROS produced by activated phagocytes or other ROS-producing cells. Oxidative modifications can have different effects on T-cell function. Indeed, they can stimulate T-cell activation but they can be also detrimental. These opposite effects of oxidation likely depend on different factors such as ROS concentration and source and also on the differentiation status of the T cells. Despite the well-stablished fact that ROS represent important modulators of T-cell activation, the precise molecular mechanisms of their action are far from clear. Here, we summarize the present knowledge on redox regulation of T-cell function with a particular emphasis on the redox regulation of TCR signaling.

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Section: T-cell Activation Is Sensitive To Oxidationmentioning

confidence: 99%

Redox regulation of T-cell receptor signaling

Simeoni

Bogeski

2015

Biological Chemistry

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“…MDSCs produce calcium-binding proteins S100A8 and S100A9, contributing to increased ROS production through binding and potentiating NADPH oxidase, specifically generating superoxide anions [ 74 ]. In the presence of water, hydrogen peroxide is produced, which is a potent suppressor of T-cell activity [ 75 , 76 ]. The S100 proteins can also stimulate MDSC induction and accumulation, acting as a positive feedback loop [ 39 ].…”

Section: T-cell Suppression By Mdscsmentioning

confidence: 99%

Immunosuppressive Effects of Myeloid-Derived Suppressor Cells in Cancer and Immunotherapy

Krishnamoorthy

Gerhardt

Vareki

2021

Cells

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The primary function of myeloid cells is to protect the host from infections. However, during cancer progression or states of chronic inflammation, these cells develop into myeloid-derived suppressor cells (MDSCs) that play a prominent role in suppressing anti-tumor immunity. Overcoming the suppressive effects of MDSCs is a major hurdle in cancer immunotherapy. Therefore, understanding the mechanisms by which MDSCs promote tumor growth is essential for improving current immunotherapies and developing new ones. This review explores mechanisms by which MDSCs suppress T-cell immunity and how this impacts the efficacy of commonly used immunotherapies.

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1988

Arch Surg

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Hydrogen Peroxide—Mediated Inhibition of T-Cell Response to Mitogens Is a Result of Direct Action on T Cells

Cited by 16 publications

References 24 publications

Redox regulation of T-cell receptor signaling

Redox regulation of T-cell receptor signaling

Immunosuppressive Effects of Myeloid-Derived Suppressor Cells in Cancer and Immunotherapy

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