2002
DOI: 10.1128/iai.70.9.5202-5207.2002
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Hydrogen Peroxide-Mediated Killing ofCaenorhabditis elegansbyStreptococcus pyogenes

Abstract: Caenorhabditis elegans is currently introduced as a new, facile, and cheap model organism to study the pathogenesis of gram-negative bacteria such as Pseudomonas aeruginosa and Salmonella enterica serovar Typhimurium. The mechanisms of killing involve either diffusible exotoxins or infection-like processes. Recently, it was shown that also some gram-positive bacteria kill C. elegans, although the precise mechanisms of killing remained open. We examined C. elegans as a pathogenesis model for the gram-positive b… Show more

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Cited by 90 publications
(84 citation statements)
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“…The release of hydrogen peroxide by S. pneumoniae can also damage host cells and has been shown to contribute to the induction of apoptosis of neuronal cells in a meningitis infection model (6,10,22). Interestingly, similar to our results, Bolm et al have shown that many streptococcal species, including S. pneumoniae and S. pyogenes, kill C. elegans by producing hydrogen peroxide (5,27). …”
Section: Discussionsupporting
confidence: 80%
See 1 more Smart Citation
“…The release of hydrogen peroxide by S. pneumoniae can also damage host cells and has been shown to contribute to the induction of apoptosis of neuronal cells in a meningitis infection model (6,10,22). Interestingly, similar to our results, Bolm et al have shown that many streptococcal species, including S. pneumoniae and S. pyogenes, kill C. elegans by producing hydrogen peroxide (5,27). …”
Section: Discussionsupporting
confidence: 80%
“…By identifying mutants altered in nematode killing, we found that E. faecium releases substantial amounts of the reactive oxygen species hydrogen peroxide and that hydrogen peroxide is responsible for nematode killing. Other bacterial pathogens, including Streptococcus pneumoniae and Streptococcus pyogenes, also produce hydrogen peroxide that kills C. elegans (5,27,53). Hydrogen peroxide produced by S. pneumoniae has been shown to contribute to virulence by damaging host tissue (6,10,22).…”
mentioning
confidence: 99%
“…In fact, production of reactive oxygen species can almost completely account for the observed killing of C. elegans by some bacterial pathogens, such as E. faecium ( Jansen et al 2002;Bolm et al 2004b;Moy et al 2004). E. faecium was originally characterized as not pathogenic to C. elegans when grown under atmospheric conditions (Garsin et al 2001).…”
Section: Elegans Produces Ros In Response To Pathogensmentioning
confidence: 99%
“…In these cases, killing can be abrogated by the addition of enzymes such as 1 catalase that break down ROS ( Jansen et al 2002;Bolm et al 2004b;Moy et al 2004). It was suggested that E. faecalis may also kill C. elegans in this manner (Bolm et al 2004a).…”
mentioning
confidence: 99%
“…However, the upregulation of a number of antimicrobial factors appears critical for host survival (R. C. May and M. C. W. van den Berg, unpublished results), and many of these factors appear to be constitutively upregulated in long-lived strains (Murphy et al 2003;McElwee et al 2004). On the basis of other C. elegans pathogen models (Mahajan-Miklos et al 1999;Tan et al 1999a,b;Jansen et al 2002;Moy et al 2004), Cryptococcus may also produce toxins while inside the nematode host. Interestingly, long-lived C. elegans strains also show dramatic upregulation of broad-spectrum detoxification mechanisms (Gems and McElwee 2005).…”
Section: Discussionmentioning
confidence: 99%