Hydrogen Peroxide Stimulates Exosomal Cathepsin B Regulation of the Receptor for Advanced Glycation End‐Products (RAGE)

Downs, Charles A.; Dang, Viet Anh; Johnson, Nicholle M.; Denslow, Nancy D.; Alli, Abdel A.

doi:10.1002/jcb.26219

Cited by 27 publications

(23 citation statements)

References 38 publications

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“…RAGE is a 35 kilodalton transmembrane receptor of the immunoglobulin superfamily, and it is widely expressed, predominantly in the lungs [31,32]. Experimental data indicated that RAGE is mainly presented on vascular smooth muscle cells [33], airway smooth muscle cells (ASM), endothelial cells and pulmonary macrophages [34]. Additionally, there is clinical evidence that neutrophilic airway inflammation in COPD and asthma is associated with reduced soluble RAGE [35].…”

Section: Discussionmentioning

confidence: 99%

Association of RAGE gene multiple variants with the risk for COPD and asthma in northern Han Chinese

Niu

et al. 2019

Aging

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Clinical and experimental data have shown that the receptor for advanced glycation end products (RAGE) is implicated in the pathogenesis of respiratory disorders. In this study, we genotyped five widely-evaluated variants in RAGE gene, aiming to assess their association with the risk for chronic obstructive pulmonary disease (COPD) and asthma in northern Han Chinese. Genotypes were determined in 105 COPD patients, 242 asthma patients and 527 controls. In single-locus analysis, there was significant difference in the genotype distributions of rs1800624 between COPD patients and controls ( p =0.022), and the genotype and allele distributions of rs1800625 differed significantly ( p =0.040 and 0.016) between asthma patients and controls. Haplotype analysis revealed that haplotype T-A-G-T (allele order: rs1800625, rs1800624, rs2070600, rs184003) was significantly associated with a reduced COPD risk (OR=0.32, 95% CI: 0.06-0.60), and haplotype T-A-A-G was significantly associated with a reduced asthma risk (OR=0.19, 95% CI: 0.04-0.96). Further haplotype-phenotype analysis showed that high- and low-density lipoprotein cholesterol and blood urea nitrogen were significant mediators for COPD ( p sim =0.041, 0.043 and 0.030, respectively), and total cholesterol was a significant mediator for asthma ( p sim =0.009). Taken together, our findings indicate that RAGE gene is a promising candidate for COPD and asthma, and importantly both disorders are genetically heterogeneous.

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Section: Discussionmentioning

confidence: 99%

Association of RAGE gene multiple variants with the risk for COPD and asthma in northern Han Chinese

Niu

et al. 2019

Aging

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“…Our previous work has also shown a role for RAGE in response to vesicle-mediated protein transport in that exosomes obtained from cells treated with H 2 O 2 promote RAGE expression in alveolar epithelial cells. [35] This suggests that RAGE may play a role in directing the content and formation of exosomes in the alveolus.…”

Section: Discussionmentioning

confidence: 99%

RAGE-induced changes in the proteome of alveolar epithelial cells

Downs

Johnson

Tsaprailis

et al. 2018

Journal of Proteomics

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In the present study, we undertook the first proteomic evaluation of RAGE-dependent processes in alveolar epithelial cells. The alveolar epithelium is a primary target during acute lung injury, and our data support a role for RAGE in gene transcription, protein transport, and response to stimuli. More over our data suggest that RAGE is a critical driver of redox regulation in the alveolar epithelium. The conclusions of the present work assist to unravel the molecular events that underlie the function of RAGE in alveolar epithelial cells and have implications for our understanding of RAGE signaling during lung injury. Our study was the first proteomic comparison showing the effects of RAGE activation from alveolar epithelial cells that constitutively express RAGE and these results can affect a wide field of lung biology, pulmonary therapeutics, and proteomics.

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“…We have summarized the key characteristics of the studies in Table 1. Of these studies, nine (30%) listed nurses as first authors (Cybulska et al, 2019; Downs et al, 2018; Ferranti et al, 2017; Gregory et al, 2013; Heitkemper et al, 2016; Lyon et al, 2018; Menzies et al, 2020; Starkweather et al, 2017; Thompson et al, 2019). Additionally, one research abstract (3.3%) listed nurse authors as both first and senior author (Faucher et al, 2019), and one study (3.3%) included a nurse as senior, but not first, author (Chen et al, 2019).…”

Section: Resultsmentioning

confidence: 99%

“…Metabolomics studies identified for this review were published in a wide array of biology/biochemistry, clinical, specialty, and nursing journals. Seven papers (23.3%) were published in biology/biochemistry journals (Alvarez et al, 2017; Chen et al, 2018, 2019; Downs et al, 2018; Gregory et al, 2013; Irving et al, 2015; Wang et al, 2018b). Eight papers (26.7%) were published in clinical journals (Cybulska et al, 2019; Hollister et al, 2019; Lu et al, 2016; Mapstone et al, 2017; Mayers et al, 2014; Menzies et al, 2020; Wang et al, 2018a, 2019).…”

Section: Resultsmentioning

confidence: 99%

Metabolomics Research Conducted by Nurse Scientists: A Systematic Scoping Review

Kimble

Leslie

Carlson

2020

Biological Research For Nursing

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Metabolomics, one of the newest omics, allows for investigation of holistic responses of living systems to myriad biological, behavioral, and environmental factors. Researcher use metabolomics to examine the underlying mechanisms of clinically observed phenotypes. However, these methods are complex, potentially impeding their uptake by scientists. In this scoping review, we summarize literature illustrating nurse scientists’ use of metabolomics. Using electronic search methods, we identified metabolomics investigations conducted by nurse scientists and published in English-language journals between 1990 and November 2019. Of the studies included in the review ( N = 30), 9 (30%) listed first and/or senior authors that were nurses. Studies were conducted predominantly in the United States and focused on a wide array of clinical conditions across the life span. The upward trend we note in the use of these methods by nurse scientists over the past 2 decades mirrors a similar trend across scientists of all backgrounds. A broad range of study designs were represented in the literature we reviewed, with the majority involving untargeted metabolomics ( n = 16, 53.3%) used to generate hypotheses ( n = 13, 76.7%) of potential metabolites and/or metabolic pathways as mechanisms of clinical conditions. Metabolomics methods match well with the unique perspective of nurse researchers, who seek to integrate the experiences of individuals to develop a scientific basis for clinical practice that emphasizes personalized approaches. Although small in number, metabolomics investigations by nurse scientists can serve as the foundation for robust programs of research to answer essential questions for nursing.

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Hydrogen Peroxide Stimulates Exosomal Cathepsin B Regulation of the Receptor for Advanced Glycation End‐Products (RAGE)

Cited by 27 publications

References 38 publications

Association of RAGE gene multiple variants with the risk for COPD and asthma in northern Han Chinese

Association of RAGE gene multiple variants with the risk for COPD and asthma in northern Han Chinese

RAGE-induced changes in the proteome of alveolar epithelial cells

Metabolomics Research Conducted by Nurse Scientists: A Systematic Scoping Review

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