Hydrogen-rich saline promotes motor functional recovery following peripheral nerve autografting in rats

Zhang, Yong‑Guang; Sheng, Qing‐Song; Wang, Zhijun; Lv, Li; Zhao, Wei; Chen, Jianmei; Xu, Hao

doi:10.3892/etm.2015.2518

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…For example, it has been reported previously that HS injection prevents cognitive deficits in animal models following traumatic brain injury, effects which were proposed to involve antioxidant activity and activation of BDNF-related synaptic plasticity [16]. HS has also been shown to alleviate peripheral nerve injury and promote functional recovery after sciatic nerve autografting in rats [17]. Moreover, hydrogen-rich water prevents the development and progression of depressive-like behavior in rats, through its capacity to inhibit inflammasome activation [18].…”

Section: Discussionmentioning

confidence: 99%

Hydrogen-rich saline promotes microglia M2 polarization and complement-mediated synapse loss to restore behavioral deficits following hypoxia-ischemic in neonatal mice via AMPK activation

Chu

Cao

et al. 2019

J Neuroinflammation

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Background Hypoxia-ischemia (HI) during the perinatal period is one of the most common causes of acute mortality and chronic neurologic morbidity. Hydrogen-rich saline (HS) treatment in neonatal mice has been reported to alleviate brain injury following HI, but the mechanisms involved are not known. Methods A modified version of the Rice-Vannucci method for the induction of neonatal HI brain injury was performed on postnatal day 7 mouse pups. Animals or BV2-cells received HS and an AMPK inhibitor at indicative time post-injury. Results In the current study, we show that HS treatment attenuated the accumulation of CD11b + /CD45 high cells, suppressed HI-induced neuro-inflammation, induced microglial anti-inflammatory M2 polarization, was associated with promoting AMPK activation, and inhibited nuclear factor-κB activation as demonstrated both in vivo and in vitro. In addition, HS treatment reversed HI-induced neurological disabilities, was associated with improving damaged synapses, and restored the expression levels of synaptophysin and postsynaptic density protein 95 following HI insult. Furthermore, HI insult which increased levels of complement component C1q, C3, and C3aR1 was observed. Importantly, C1q deposited in the infarct core and lesion boundary zone following HI injury, was found to co-localize within regions of synapse loss, whereas HS treatment reversed these effects of HI on synapse loss and complement component levels. Notably, the AMPK inhibitor reversed the beneficial effects of HS as described above. Conclusions These results demonstrate that HS restored behavioral deficits after HI in neonatal mice. These beneficial effects, in part, involve promoting microglia M2 polarization and complement-mediated synapse loss via AMPK activation. Electronic supplementary material The online version of this article (10.1186/s12974-019-1488-2) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Hydrogen-rich saline promotes microglia M2 polarization and complement-mediated synapse loss to restore behavioral deficits following hypoxia-ischemic in neonatal mice via AMPK activation

Chu

Cao

et al. 2019

J Neuroinflammation

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“…Multiple studies in recent years have found that molecular hydrogen can reduce the production of inflammatory factors 28,38,39 and increase the release of anti-inflammatory factors, thereby playing an anti-inflammatory role. Hydrogen gas also has anti-apoptotic effects 32,40,41 and affects the hormone levels and activity. 42,43 Based on the above research, we found that the formation of chronic nasal mucosal inflammation is closely related to oxidative stress mechanisms.…”

Section: Therapeutic Mechanism Of Hydrogenmentioning

confidence: 99%

Research Progress of Hydrogen on Chronic Nasal Inflammation

Jin¹,

Tan²,

Fan³

et al. 2023

JIR

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Chronic nasal mucosal inflammatory disease is a common nasal disease, which is involved by inflammatory cells and a variety of cytokines. Its main pathological features are inflammatory reaction, increased secretion, mucosal swelling and thickening of nasal cavity or paranasal sinuses.It mainly includes chronic rhinitis (divided into allergic rhinitis, non-allergic rhinitis), chronic sinusitis (divided into with nasal polyps, without nasal polyps type), etc.The main symptoms of chronic rhinitis are nasal itching, sneezing, runny nose, and nasal congestion. The main symptoms of chronic sinusitis are nasal congestion, purulent or sticky nasal discharge, headache, and reduced sense of smell. They are a type of disease with a high incidence rate and seriously affect the quality of human life.Although the etiology and treatment of this type of disease have been extensively studied, there are still many aspects that are unclear.Currently, oxidative stress is believed to be an important link in the pathogenesis of chronic inflammatory diseases of the nasal mucosa. Therefore, anti-oxidative stress is a direction of research for the treatment of chronic nasal mucosal inflammatory diseases.Hydrogen, as a medically therapeutic gas, has been extensively studied for its antioxidant, anti-inflammatory, and anti-damage properties, and has been used in the treatment of various diseases.Although there are relatively few studies on the use of hydrogen for nasal inflammation, its positive effects have also been found. This article systematically summarizes the relevant research on the use of hydrogen to improve chronic nasal mucosal inflammation, with the aim of clarifying the ideas and indicating the direction for further research in the future.

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Prospects of molecular hydrogen in perioperative neuroprotection from basic research to clinical application

Wang

Xie

2020

Current Opinion in Anaesthesiology

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Purpose of review The current systematic review summarizes recent, basic clinical achievements regarding the neuroprotective effects of molecular hydrogen in distinct central nervous system conditions. Recent findings Perioperative neuroprotection remains a major topic of clinical anesthesia. Various gaseous molecules have previously been explored as a feasible therapeutic option in neurological disorders. Among them, molecular hydrogen, which has emerged as a novel and potential therapy for perioperative neuroprotection, has received much attention. Summary Fundamental and clinical evidence supports the antioxidant, antiinflammation, antiapoptosis and mitochondrial protective effects of hydrogen in the pathophysiology of nervous system diseases. The clinically preventive and therapeutic effects of hydrogen on different neural diseases, however, remain uncertain, and the lack of support by large randomized controlled trials has delayed its clinical application.

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Hydrogen-rich saline promotes motor functional recovery following peripheral nerve autografting in rats

Cited by 3 publications

References 28 publications

Hydrogen-rich saline promotes microglia M2 polarization and complement-mediated synapse loss to restore behavioral deficits following hypoxia-ischemic in neonatal mice via AMPK activation

Hydrogen-rich saline promotes microglia M2 polarization and complement-mediated synapse loss to restore behavioral deficits following hypoxia-ischemic in neonatal mice via AMPK activation

Research Progress of Hydrogen on Chronic Nasal Inflammation

Prospects of molecular hydrogen in perioperative neuroprotection from basic research to clinical application

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