2020
DOI: 10.1038/s41598-020-68930-2
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Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults: a randomized, double-blind, controlled trial

Abstract: The evidence for the beneficial effects of drinking hydrogen-water (HW) is rare. We aimed to investigate the effects of HW consumption on oxidative stress and immune functions in healthy adults using systemic approaches of biochemical, cellular, and molecular nutrition. In a randomized, double-blind, placebo-controlled study, healthy adults (20–59 y) consumed either 1.5 L/d of HW ( n = 20) or plain water (PW, n = 18) for 4 weeks. The changes from baseline to the 4t… Show more

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Cited by 62 publications
(51 citation statements)
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“…Healthy adults drink 4 weeks of HRW at 1.5 L per week, which can reduce cell death and inflammation by regulating the Toll-like receptor-nuclear factorkappa B (TLR-NF-κB) signaling and enhance the antioxidant capacity of the body. When measured by using the dissolved H 2 analyzer, the hydrogen concentration of HRW was 0.753 ± 0.012 mg/l (24). A hydrogen-rich saline injection containing 1 ppm H 2 can safely and effectively reduce the active phase of rheumatoid arthritis (25).…”
Section: Clinical Application and Characteristics Of Hydrogenmentioning
confidence: 98%
“…Healthy adults drink 4 weeks of HRW at 1.5 L per week, which can reduce cell death and inflammation by regulating the Toll-like receptor-nuclear factorkappa B (TLR-NF-κB) signaling and enhance the antioxidant capacity of the body. When measured by using the dissolved H 2 analyzer, the hydrogen concentration of HRW was 0.753 ± 0.012 mg/l (24). A hydrogen-rich saline injection containing 1 ppm H 2 can safely and effectively reduce the active phase of rheumatoid arthritis (25).…”
Section: Clinical Application and Characteristics Of Hydrogenmentioning
confidence: 98%
“…Hydrogen can react with the most toxic ROS, hydroxyl radicals ( • OH), and detoxify them to harmless water (2 • OH + H 2 → 2H 2 O). Many studies have reported that H 2 not only exhibits antioxidative stress effects, but also has various anti-inflammatory and anti-allergic effects [ 9 , 10 , 11 , 12 ]. In this study, we tested the effects of hydrogen-generating material named ULH-002 containing hydrogen-occluded microporous silica on ultraviolet-A (UVA)-induced cellular ROS generation, cell death, collagen loss and melanogenesis in human keratinocytes, fibroblasts, melanocytes and three-dimensional skin equivalents.…”
Section: Introductionmentioning
confidence: 99%
“…Hydrogen molecules can easily permeate cellular membranes and reduce oxidative stress [ 30 ]. Recently, a randomized, double-blind, controlled clinical trial reported that hydrogen-rich water could increase serum antioxidant capacity and reduce inflammatory responses in healthy adults [ 31 ]. However, dissolved hydrogen molecules escape very easily from the solution.…”
Section: Discussionmentioning
confidence: 99%