Hydrogen sulfide alleviates cadmium toxicity through regulations of cadmium transport across the plasma and vacuolar membranes in Populus euphratica cells

Sun, Jian; Wang, Ruigang; Zhang, Xuan; Yu, Yan; Zhao, Rui; Li, Zongyun; Chen, Shao‐Liang

doi:10.1016/j.plaphy.2013.01.003

Cited by 154 publications

(93 citation statements)

References 39 publications

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“…Alterations of hydrogen sulfide metabolism have important pathological consequences, establishing the clinical relevance of this molecule (Łowicka and Bełtowski, 2007;Szabó, 2007;Wang, 2012). In addition to the protective effects of hydrogen sulfide against a wide array of different stresses that have been demonstrated in plants (Zhang et al, 2008Wang et al, 2010;Jin et al, 2011;Dawood et al, 2012;Li et al, 2012aLi et al, , 2012bCheng et al, 2013;Christou et al, 2013;Sun et al, 2013), this molecule has also been shown to regulate plant processes that are critical for plant performance, such as photosynthesis (Chen et al, 2011), stomatal movement (García-Mata and Lamattina, 2010;Lisjak et al, 2010;Scuffi et al, 2014), and autophagy (Álvarez et al, 2012b; Gotor et al, 2013). In this study, we provide new experimental evidence that, together with our previous findings, demonstrates the role of hydrogen sulfide in regulating the progression of autophagy independently of the condition in which the autophagy originates.…”

Section: Discussionmentioning

confidence: 99%

“…Sulfide has been found to mediate increases in tolerance and protection against certain plant stresses, primarily through the increased performance of antioxidant defenses. For example, sulfide alleviates the inhibitory effects of copper and aluminum stress on wheat (Triticum aestivum) germination and barley (Hordeum vulgare) seedlings (Zhang et al, 2008Dawood et al, 2012), the effect of boron on cucumber (Cucumis sativus) root elongation , and the toxicity of cadmium in Populus euphratica (Sun et al, 2013) and alfalfa (Medicago sativa) seedlings . Sulfide also improves drought and hypoxia resistance and heat and salinity tolerance (Jin et al, 2011;Li et al, 2012b;Cheng et al, 2013;Christou et al, 2013).…”

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confidence: 99%

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Negative regulation of autophagy by sulfide in Arabidopsis thaliana is independent of reactive oxygen species

et al. 2016

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Accumulating experimental evidence in mammalian, and recently plant, systems has led to a change in our understanding of the role played by hydrogen sulfide in life processes. In plants, hydrogen sulfide mitigates stress and regulates important plant processes such as photosynthesis, stomatal movement, and autophagy, although the underlying mechanism is not well known. In this study, we provide new experimental evidence that, together with our previous findings, demonstrates the role of hydrogen sulfide in regulating autophagy. We used green fluorescent protein fluorescence associated with autophagic bodies and immunoblot analysis of the ATG8 protein to show that sulfide (and no other molecules such as sulfur-containing molecules or ammonium) was able to inhibit the autophagy induced in Arabidopsis (Arabidopsis thaliana) roots under nitrogen deprivation. Our results showed that sulfide was unable to scavenge reactive oxygen species generated by nitrogen limitation, in contrast to well-established reducers. In addition, reducers were unable to inhibit the accumulation of autophagic bodies and ATG8 protein forms to the same extent as sulfide. Therefore, we conclude that sulfide represses autophagy via a mechanism that is independent of redox conditions.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Negative regulation of autophagy by sulfide in Arabidopsis thaliana is independent of reactive oxygen species

et al. 2016

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“…In plants, numerous studies have shown that sulfide increases tolerance/resistance against stress conditions, such as metal stress (Zhang et al 2008 ;Dawood et al 2012 ;Wang et al 2010 ;Sun et al 2013 ;, drought (Jin et al 2011 ), hypoxia (Cheng et al 2013 ), salinity (Christou et al 2013 ;Wang et al 2012 ), and heat . Moreover, sulfide has been also demonstrated to regulate many essential plant processes, like photosynthesis (Chen et al 2011 ), stomatal movement (Garcia-Mata and Lamattina 2010 ;Lisjak et al 2010 ), flower senescence (Zhang et al 2011 ), and postharvest life of fruits (Hu et al 2012 ).…”

Section: Cysteine Homeostasis In the Cytosolmentioning

confidence: 99%

Signaling in the plant cytosol: cysteine or sulfide?

et al. 2014

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Cysteine (Cys) is the first organic compound containing reduced sulfur that is synthesized in the last stage of plant photosynthetic assimilation of sulfate. It is a very important metabolite not only because it is crucial for the structure, function and regulation of proteins but also because it is the precursor molecule of an enormous number of sulfur-containing metabolites essential for plant health and development. The biosynthesis of Cys is accomplished by the sequential reaction of serine acetyltransferase (SAT) and O-acetylserine(thiol)synthase (OASTL). In Arabidopsis thaliana, the analysis of specific mutants of members of the SAT and OASTL families has demonstrated that the cytosol is the compartment where the bulk of Cys synthesis takes place and that the cytosolic OASTL enzyme OAS-A1 is the responsible enzyme. Another member of the OASTL family is DES1, a novel L-cysteine desulfhydrase that catalyzes the desulfuration of Cys to produce sulfide, thus acting in a manner opposite to that of OAS-A1. Detailed studies of the oas-a1 and

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“…Accumulating evidence suggests that H 2 S acts as a gaseous regulator in response to abiotic stresses, root organogenesis, stomatal movement, autophagy, and senescence in plants [10][11][12]. Recently, there is evidence showing that H 2 S functions in response to Cd stress in Populus euphratica cells, Bermuda grass and Arabidopsis [13][14][15]. However, whether H 2 S plays some role in wheat grain germination under Cd stress and the underlying mechanism are still unknown.…”

Section: Introductionmentioning

confidence: 99%

Hydrogen Sulfide Promotes Wheat Grain Germination Under Cadmium Stress

Huang

Shao-can

et al. 2015

Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci.

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Hydrogen sulfide (H 2 S) has proved to be a multifunctional signaling molecule involved in plant development and response to abiotic stresses. In the present study, the effects of H 2 S donor, sodium hydrosulfide (NaHS) on the germination of wheat (Triticum aestivum L.) grains under cadmium stress was investigated. With the increase in Cd concentration, the germination percentage of wheat grains decreased steadily. NaHS pretreatment alleviated cadmium-induced germination inhibition in a dose-dependent manner, with the optimal concentration of 0.9 mM. Further studies showed that NaHS pretreatment could promote the activities of amylase and esterase, reducing cadmium-induced disturbance of plasma membrane integrity in the radicle tips, and sustain lower levels of superoxide radicals, hydrogen peroxide and malondialdehyde in germinating wheat grains. Besides, NaHS significantly promoted the accumulation of free amino acids in grains exposed to cadmium. Further investigation showed that NaHS pretreatment stimulated the activities of peroxidase, catalase and acorbate peroxidase and inhibited that of lipoxygenase. In addition, a higher level of endogenous H 2 S in wheat grains was observed in NaHSpretreated wheat grains. These data indicate that H 2 S ameliorated cadmium-stress in germinating wheat grains by modulating the antioxidant system.

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Hydrogen sulfide alleviates cadmium toxicity through regulations of cadmium transport across the plasma and vacuolar membranes in Populus euphratica cells

Cited by 154 publications

References 39 publications

Negative regulation of autophagy by sulfide in Arabidopsis thaliana is independent of reactive oxygen species

Negative regulation of autophagy by sulfide in Arabidopsis thaliana is independent of reactive oxygen species

Signaling in the plant cytosol: cysteine or sulfide?

Hydrogen Sulfide Promotes Wheat Grain Germination Under Cadmium Stress

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