2018
DOI: 10.1152/ajpcell.00147.2018
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Hydrogen sulfide alleviates hyperhomocysteinemia-mediated skeletal muscle atrophy via mitigation of oxidative and endoplasmic reticulum stress injury

Abstract: Although hyperhomocysteinemia (HHcy) occurs due to the deficiency in cystathionine-β-synthase (CBS) causing skeletal muscle dysfunction, it is still unclear whether this effect is mediated through oxidative/endoplasmic reticulum (ER)-stress or both. Nevertheless, there is no treatment option available to improve HHcy-mediated muscle injury. Hydrogen sulfide (HS) is an anti-oxidant compound and patients with CBS mutation do not produce HS. In this study, we hypothesized that HS mitigates HHcy-induced redox imba… Show more

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Cited by 52 publications
(55 citation statements)
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“…The Paw Grip Endurance (PaGE) test demonstrated that in both groups (P10 and adults) the time spent on the grid was lower in hHCY rats indicating diminished muscle strength. These data are consistent with previously obtained data, where hHCY exerted detrimental effects on muscle force generation and fatigability (Veeranki et al, 2015; Majumder et al, 2018b; Yakovleva et al, 2018). The molecular mechanisms of detrimental effects of hHCY include mitochondrial dysfunctions, oxidative/endoplasmic reticulum (ER)‐stress and secretion of pro‐inflammatory cytokines (Veeranki et al, 2015; Majumder et al, 2018a).…”
Section: Discussionsupporting
confidence: 93%
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“…The Paw Grip Endurance (PaGE) test demonstrated that in both groups (P10 and adults) the time spent on the grid was lower in hHCY rats indicating diminished muscle strength. These data are consistent with previously obtained data, where hHCY exerted detrimental effects on muscle force generation and fatigability (Veeranki et al, 2015; Majumder et al, 2018b; Yakovleva et al, 2018). The molecular mechanisms of detrimental effects of hHCY include mitochondrial dysfunctions, oxidative/endoplasmic reticulum (ER)‐stress and secretion of pro‐inflammatory cytokines (Veeranki et al, 2015; Majumder et al, 2018a).…”
Section: Discussionsupporting
confidence: 93%
“…In our study we present for the first time changes of the synaptic transmission during postnatal development in rat neuromuscular junction caused by elevated levels of the endogenous amino acid HCY during the prenatal period. Several previous studies reported that an increased level of HCY leads to functional impairments and weakness of skeletal muscle (Veeranki and Tyagi, 2013; Ng et al, 2012; Swart et al, 2013; Majumder et al, 2017, 2018a,b). Children born with severe homocystinuria due to CBS deficiency exhibit low body weight and skeletal muscle myopathy (Picker and Levy, 2010).…”
Section: Discussionmentioning
confidence: 99%
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“…We opine that additional pathways might be at work during neoangiogenesis (Majumder et al. ); however, further investigation needs to be undertaken involving similar but not identical scenarios wherein muscle dysfunction is the outcome of metabolic derangement. In brief, H 2 S does hold potential ramifications toward developing it as a clinically relevant therapeutic option for chronic conditions that are implicated in a host of inflammatory and cellular stress injury including the apparent defect in the neoangiogenesis (Majumder et al.…”
Section: Discussionmentioning
confidence: 95%
“…In brief, H 2 S does hold potential ramifications toward developing it as a clinically relevant therapeutic option for chronic conditions that are implicated in a host of inflammatory and cellular stress injury including the apparent defect in the neoangiogenesis (Majumder et al. ).…”
Section: Discussionmentioning
confidence: 99%