Hydrogen sulfide ameliorates acute lung injury induced by infrarenal aortic cross-clamping by inhibiting inflammation and angiopoietin 2 release

Abstract

The study indicates that HS may play a protective role in IAC-induced acute lung injury in rats by inhibiting inflammation and Ang2 release.

MicroRNA-21-Regulated Activation of the Akt Pathway Participates in the Protective Effects of H₂S against Liver Ischemia–Reperfusion Injury

“…Rats in the other two I/R groups received an injec-tion of GYY4137 (133 µmol/kg) or PAG (50 mg/kg) (SigmaAldrich, Shanghai, China), dissolved in 0.2 mL of normal saline. 6,9,16) A group of 6 healthy untreated rats and two groups of 6 sham-operated rats receiving an injection of GYY4137 or PAG as above were included in this study as controls. Saline, GYY4137 and PAG were administered intraperitoneally 1 h prior to the commencement of surgery.…”

“…6,17,21) Several H 2 S-releasing drugs have demonstrated a considerable promise because of its safety and effectiveness in the management of many disorders in animal experiments, and have been evaluated in clinical trials. 2) In agreement with the present results, H 2 S has displayed protective activities against the injury to several organs including the heart, 17,21) liver 9) and brain, 4) induced by I/R, and lung injury induced by various factors.…”

“…These results are supported by several previous reports. 5,6,9,17) Because of its lipophilic structure as a gasotransmitter, 25) it is likely that H 2 S may have many variable targets without a confirmed receptor.…”

“…[3][4][5][6][7][8] We have previously reported that administration of sodium hydrosulfide (NaHS), a donor of H 2 S, attenuated the severity of liver injury in a rat model of hepatic I/R. 9) However, the underlying mechanisms accounting for the activities of H 2 S against hepatic I/R-induced injury remain unclear.…”

“…We, therefore, addressed this question by utilizing a warm liver I/R model in rats, in which GYY4137 [a water-soluble and slow-releasing H 2 S donor 16) ] and DL-propargylglycine (PAG) [an irreversible inhibitor of CSE 6,9,17) ] were applied. We also examined the regulatory participation of miR-21 on the protective activity of H 2 S in a cell model of hypoxia/reoxygenation (H/R).…”