Hydrogen sulfide and vascular regulation – An update

Lv, Boyang; Chen, Selena; Tang, Chaoshu; Jin, Hongfang; Du, Junbao; Huang, Yaqian

doi:10.1016/j.jare.2020.05.007

Cited by 104 publications

(84 citation statements)

References 153 publications

(207 reference statements)

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“…Stimulation of the production of endogenous H 2 S and other thiol-active antioxidants by Tan IIA makes Tan IIA an ideal drug to prevent acrolein toxicity. Third, H 2 S deficiency has been implicated in aging, Alzheimer's disease, cardiovascular, and metabolic disorders [13,14,30]. Stimulating endogenous H 2 S production via the upregulation of H 2 S-producing enzymes could be a promising therapeutic approach to prevent and treat these diseases.…”

Section: Discussionmentioning

confidence: 99%

“…H 2 S is an important gaseous mediator, which is synthesized through H 2 S-synthesizing enzymes, cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3MPST) in the mammalian family. It has versatile biological functions, such as vasodilative, cardioprotective, angiogenetic, anti-aging, anti-inflammatory, and antioxidative actions [13][14][15][16][17][18]. H 2 S is a potent antioxidant.…”

Section: Introductionmentioning

confidence: 99%

“…For example, both of them possess vasodilative, anticoagulant, anti-inflammatory, and anti-oxidative actions. Second, both Tan IIA and H 2 S are proved to be effective in treating a variety of cardiovascular diseases with a common pathological basis, such as cell injury, oxidation, and inflammation [1][2][3][4][5][6][7][8][9][10][11][13][14][15]18,[22][23][24][25][26], and, third, Tan IIA is the member of the phytoestrogens. It has estrogen-like activity.…”

Section: Introductionmentioning

confidence: 99%

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Tanshinone IIA Stimulates Cystathionine γ-Lyase Expression and Protects Endothelial Cells from Oxidative Injury

et al. 2021

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Tanshinone IIA (Tan IIA), an active ingredient of Danshen, is a well-used drug to treat cardiovascular diseases. Currently, the mechanisms involved remain poorly understood. Given that many actions of Tan IIA could be similarly achieved by hydrogen sulfide (H2S), we speculated that Tan IIA might work through the induction of endogenous H2S. This study was to test this hypothesis. Exposure to endothelial cells to Tan IIA elevated H2S-synthesizing enzyme cystathionine γ-Lyase (CSE), associated with an increased level of endogenous H2S and free thiol activity. Further analysis revealed that this effect of Tan IIA was mediated by an estrogen receptor (ER) and cAMP signaling pathway. It stimulated VASP and CREB phosphorylation. Inhibition of ER or PKA abolished the CSE-elevating effect, whereas activation of ER or PKA mimicked the effect of Tan IIA. In an oxidative endothelial cell injury model, Tan IIA potently attenuated oxidative stress and inhibited cell death. In support of a role of endogenous H2S, inhibition of CSE aggerated oxidative cell injury. On the contrary, supplement of H2S attenuated cell injury. Collectively, our study characterized endogenous H2S as a novel mediator underlying the pharmacological actions of Tan IIA. Given the multifaceted functions of H2S, the H2S-stimulating property of Tan IIA could be exploited for treating many diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Tanshinone IIA Stimulates Cystathionine γ-Lyase Expression and Protects Endothelial Cells from Oxidative Injury

et al. 2021

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“…H 2 S is the third most crucial cardiovascular mediator after nitric oxide and carbon monoxide, and has been shown to prevent AS ( 27 ). When NaHS is dissolved in water, it acts as an exogenous H 2 S donor, releasing HS − and forming H 2 S with H + , with the H 2 S concentration ~33% of the initial mass of NaHS ( 28 ).…”

Section: Discussionmentioning

confidence: 99%

Hydrogen sulfide improves ox‑LDL‑induced expression levels of Lp‑PLA₂ in THP‑1 monocytes via the p38MAPK pathway

Qiu

Zhang

et al. 2021

Mol Med Rep

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Hydrogen sulfide (H 2 S) exerts an anti-atherosclerotic effect and decreases foam cell formation. Lipoprotein-associated phospholipase A2 (Lp-PLA 2 ) is a key factor involved in foam cell formation. However, the association between H 2 S and Lp-PLA 2 expression levels with respect to foam cell formation has not yet been elucidated. The present study investigated whether H 2 S can affect foam cell formation and potential signalling pathways via regulation of the expression and activity of Lp-PLA 2 . Using human monocytic THP-1 cells as a model system, it was observed that oxidized low-density lipoprotein (ox-LDL) not only upregulates the expression level and activity of Lp-PLA 2 , it also downregulates the expression level and activity of Cystathionine γ lyase. Exogenous supplementation of H 2 S decreased the expression and activity of Lp-PLA 2 induced by ox-LDL. Moreover, ox-LDL induced the expression level and activity of Lp-PLA 2 via activation of the p38MAPK signalling pathway. H 2 S blocked the expression levels and activity of Lp-PLA 2 induced by ox-LDL via inhibition of the p38MAPK signalling pathway. Furthermore, H 2 S inhibited Lp-PLA 2 activity by blocking the p38MAPK signaling pathway and significantly decreased lipid accumulation in ox-LDL-induced macrophages, as detected by Oil Red O staining. The results of the present study indicated that H 2 S inhibited ox-LDL-induced Lp-PLA 2 expression levels and activity by blocking the p38MAPK signalling pathway, thereby improving foam cell formation. These findings may provide novel insights into the role of H 2 S intervention in the progression of atherosclerosis.

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“…1 . Catalytic activities of CBS and CSE are tissue specific [ 106 ]. Also 3-mercaptopyruvate sulfurtransferase (MPST) is involved in brain H 2 S synthesis from 3-mercaptopyruvate (3-MPT).…”

Section: Neural and Glial H 2 S Biosynthesis And Mmentioning

confidence: 99%

The role of brain gaseous neurotransmitters in anxiety

2021

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Although anxiety is perhaps one of the most significant current medical and social problems, the neurochemical mechanistic background of this common condition remains to be fully understood. Multifunctional regulatory gasotransmitters are novel, atypical inorganic factors of the brain that are involved in the mechanisms of anxiety responses. Nitric oxide (NO) signaling shows ambiguous action in animal models of anxiety, while NO donors exert anxiogenic or anxiolytic effect depending on their chemical structure, dose, treatment schedule and gas release rapidity. The majority of NO synthase inhibitors act as a relatively potent axiolytic agents, while hydrogen sulfide (H2S) and carbon monoxide (CO) delivered experimentally in the form of “slow” or “fast” releasing donors have recently been considered as anxiolytic neurotransmitters. In this comprehensive review we critically summarize the literature regarding the intriguing roles of NO, H2S and CO in the neuromolecular mechanisms of anxiety in the context of their putative, yet promising therapeutic application. A possible mechanism of gasotransmitter action at the level of anxiety-related synaptic transmission is also presented. Brain gasesous neuromediators urgently require further wide ranging studies to clarify their potential value for the current neuropharmacology of anxiety disorders.

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Hydrogen sulfide and vascular regulation – An update

Abstract: Graphical abstract

Cited by 104 publications

References 153 publications

Tanshinone IIA Stimulates Cystathionine γ-Lyase Expression and Protects Endothelial Cells from Oxidative Injury

Tanshinone IIA Stimulates Cystathionine γ-Lyase Expression and Protects Endothelial Cells from Oxidative Injury

Hydrogen sulfide improves ox‑LDL‑induced expression levels of Lp‑PLA₂ in THP‑1 monocytes via the p38MAPK pathway

The role of brain gaseous neurotransmitters in anxiety

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Hydrogen sulfide and vascular regulation – An update

Abstract: Graphical abstract

Cited by 104 publications

References 153 publications

Tanshinone IIA Stimulates Cystathionine γ-Lyase Expression and Protects Endothelial Cells from Oxidative Injury

Tanshinone IIA Stimulates Cystathionine γ-Lyase Expression and Protects Endothelial Cells from Oxidative Injury

Hydrogen sulfide improves ox‑LDL‑induced expression levels of Lp‑PLA2 in THP‑1 monocytes via the p38MAPK pathway

The role of brain gaseous neurotransmitters in anxiety

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Hydrogen sulfide improves ox‑LDL‑induced expression levels of Lp‑PLA₂ in THP‑1 monocytes via the p38MAPK pathway