Hydrogen sulfide assessment in shallow pits swine housing and outside manure storage facilities

Chénard, L.; Lemay, S.P.; Laguë, C.

doi:10.13031/2013.9537

Cited by 7 publications

(9 citation statements)

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“…Furthermore, single and five exposures increased AHR. Because the barn air, in addition to endotoxins, contains dust, ammonia, microorganisms, aeroallergens [51], CO 2 , moulds [52], H 2 S [53], microorganisms and associated products such as bacterial cell wall, pig dander, fecal material and feed materials [54], more in vivo animal studies and detailed characterization of the barn air are needed to precisely identify the causative agents and their respective contributions to lung dysfunction and specific interactions of host genome and the environment.…”

Section: Resultsmentioning

confidence: 99%

Multiple exposures to swine barn air induce lung inflammation and airway hyper-responsiveness

et al. 2005

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Section: Resultsmentioning

confidence: 99%

Multiple exposures to swine barn air induce lung inflammation and airway hyper-responsiveness

et al. 2005

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“…[8] The US National Institute for Occupational Safety and Health (NIOSH) recommended maximal exposure limit of H 2 S is 10 ppm for no more than 10 min. H 2 S concentrations of 5 ppm have been documented in swine barns during normal operations;[14] however, H 2 S concentrations of nearly 1000 ppm have been recorded when various procedures associated with manure storage tanks are performed. [14] H 2 S has an unpleasant and intense odor (“rotten eggs”) at levels of 10-30 ppm, with olfactory fatigue and olfactory nerve paralysis developing at 100-150 ppm.…”

Section: Discussionmentioning

confidence: 99%

“…H 2 S concentrations of 5 ppm have been documented in swine barns during normal operations;[14] however, H 2 S concentrations of nearly 1000 ppm have been recorded when various procedures associated with manure storage tanks are performed. [14] H 2 S has an unpleasant and intense odor (“rotten eggs”) at levels of 10-30 ppm, with olfactory fatigue and olfactory nerve paralysis developing at 100-150 ppm. Additionally, pulmonary edema and apnea are associated with H 2 S levels of 300-500 ppm and with near-instant respiratory paralysis and coma associated with levels of 1000 ppm and greater.…”

Section: Discussionmentioning

confidence: 99%

Manure pit injuries: Rare, deadly, and preventable

Hallam

Liao

Choi

2012

J Emerg Trauma Shock

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A male worker entered an underground manure pit and lost consciousness. His coworker tried to rescue him and also lost consciousness in the pit. Emergency service arrived in minutes and removed both of them from the pit. Both men suffered anoxic brain injury and died in the hospital. Cases from Iowa Fatality Assessment and Control Evaluation Program Data Base program were reviewed. Occupational mortality rate was found to be 7.4 per 10,000 per year for occupational deaths related to agriculture compared to 3.1 per 10,000 per year for deaths not related to agriculture. In most of the cases associated with sewage or livestock waste handling, victims died of asphyxiation. While manure pit injury is rare, it has an extremely high fatality rate. The most effective strategy to decrease mortality is active prevention.

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“…H 2 S remains a primary chemical occupational exposure hazard in oil production, well drilling, gas refining industries (Arnold et al, 1985), as well as in farming (Chenard et al, 2003). Anosmia has long been reported, among other neurological deficits, following acute exposure to hydrogen sulfide (H 2 S) toxicity (Tvedt et al, 1991).…”

Section: Introductionmentioning

confidence: 99%

Hydrogen Sulfide Specifically Alters NAD(P)H Quinone Dehydrogenase 1 (NQO1) Olfactory Neurons in the Rat

et al. 2017

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The regions of the olfactory epithelium affected by hydrogen sulfide (H2S) toxicity in the rat present a striking similarity with the developmental olfactory zone 1 described in the mouse. This zone which is the only region containing neurons expressing NAD(P)H quinone dehydrogenase 1 (NQO1) is involved in complex behavioral responses in rodents, and other mammals, triggered by specific olfactory stimuli. We therefore sought to determine whether 1) olfactory neurons expressing NQO1 are located in the same regions in the rats and in the mice and 2) there is an overlap between olfactory neurons expressing this protein and those affected by the toxicity of H2S. Rats were exposed to H2S – 200 ppm during 3 hours, 3 consecutive days- and displayed symmetric acute segmental necrosis of the neurons and sustentacular cells of the olfactory epithelium in the dorsomedial nasal cavity. We found that expression of NQO1 in Sprague-Dawley rats spatially recapitulated that of the mouse. The degree of agreement or overlap between these 2 populations of neurons (necrosis vs. NQO1 expression) reached 80.2 %. Although the underlying mechanisms accounted for the high sensitivity for NQO1 neurons -or the relative protection of non NQO1 neurons- to sulfide toxicity remain to be established, this observation is offering an intriguing approach that could be used to acutely suppress the pool of neural cells in olfactory zone I and to understand the mechanisms of toxicity and protection of other populations of neurons exposed to sulfide.

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Hydrogen sulfide assessment in shallow pits swine housing and outside manure storage facilities

Cited by 7 publications

References 0 publications

Multiple exposures to swine barn air induce lung inflammation and airway hyper-responsiveness

Multiple exposures to swine barn air induce lung inflammation and airway hyper-responsiveness

Manure pit injuries: Rare, deadly, and preventable

Hydrogen Sulfide Specifically Alters NAD(P)H Quinone Dehydrogenase 1 (NQO1) Olfactory Neurons in the Rat

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