Hydrogen sulfide attenuates cardiac injury in takotsubo cardiomyopathy by alleviating oxidative stress

Zhang, Zhihong; Jin, Sheng; Teng, Xu; Duan, Xiaocui; Chen, Yuhong; Wu, Yuming

doi:10.1016/j.niox.2017.04.010

Cited by 44 publications

(30 citation statements)

References 55 publications

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“…Intriguingly, Zhang et al. (38) described the protective effects of hydrogen sulfide in isoproterenol-treated rats, a benefit apparently resulting from reversal of catecholamine-induced reactive oxygen species generation. However, ONOO – -related markers were not assessed in this study.…”

Section: Discussionmentioning

confidence: 99%

Nitrosative Stress as a Modulator of Inflammatory Change in a Model of Takotsubo Syndrome

Surikow

Nguyen

Stafford

et al. 2018

JACC: Basic to Translational Science

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Section: Discussionmentioning

confidence: 99%

Nitrosative Stress as a Modulator of Inflammatory Change in a Model of Takotsubo Syndrome

Surikow

Nguyen

Stafford

et al. 2018

JACC: Basic to Translational Science

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“…A recent study by Zhang et al . 79 found that hydrogen sulfide relieved cardiac dysfunction in animal models by decreasing oxidative stress. It has been reported that the level of oxidative stress correlates to the extent of myocardial dysfunction in TTS patients in the acute recovery phase.…”

Section: Pathophysiologymentioning

confidence: 99%

International Expert Consensus Document on Takotsubo Syndrome (Part I): Clinical Characteristics, Diagnostic Criteria, and Pathophysiology

Ghadri

Wittstein

Prasad

et al. 2018

European Heart Journal

1,175

1,284

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Takotsubo syndrome (TTS) is a poorly recognized heart disease that was initially regarded as a benign condition. Recently, it has been shown that TTS may be associated with severe clinical complications including death and that its prevalence is probably underestimated. Since current guidelines on TTS are lacking, it appears timely and important to provide an expert consensus statement on TTS. The clinical expert consensus document part I summarizes the current state of knowledge on clinical presentation and characteristics of TTS and agrees on controversies surrounding TTS such as nomenclature, different TTS types, role of coronary artery disease, and etiology. This consensus also proposes new diagnostic criteria based on current knowledge to improve diagnostic accuracy.

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“…A novel H 2 S-donor-4-carboxyphenyl isothiocyanate (4CPI) treatment significantly decreased ROS levels, oxidative damage and ischemia/reperfusion-induced tissue injury in an in vivo model of acute myocardial infarction in rats [ 39 ]. Treatment with H 2 S donor (NaHS)-reduced NADPH oxidase 4 (NOX4) and ROS levels and cellular oxidative stress, ameliorating cardiac dysfunction in Takotsubo cardiomyopathy (TCM) in rats [ 40 ]. The organosulfur compound diallyl trisulfide (DATS) treatment in mice attenuated cardiac dysfunction after heart failure via induction of angiogenesis.…”

Section: H 2 S Treatment In Animal Models Of DImentioning

confidence: 99%

Role of Hydrogen Sulfide in NRF2- and Sirtuin-Dependent Maintenance of Cellular Redox Balance

2018

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Hydrogen sulfide (H2S) has arisen as a critical gasotransmitter signaling molecule modulating cellular biological events related to health and diseases in heart, brain, liver, vascular systems and immune response. Three enzymes mediate the endogenous production of H2S: cystathione β-synthase (CBS), cystathione γ-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3-MST). CBS and CSE localizations are organ-specific. 3-MST is a mitochondrial and cytosolic enzyme. The generation of H2S is firmly regulated by these enzymes under normal physiological conditions. Recent studies have highlighted the role of H2S in cellular redox homeostasis, as it displays significant antioxidant properties. H2S exerts antioxidant effects through several mechanisms, such as quenching reactive oxygen species (ROS) and reactive nitrogen species (RNS), by modulating cellular levels of glutathione (GSH) and thioredoxin (Trx-1) or increasing expression of antioxidant enzymes (AOE), by activating the transcription factor nuclear factor (erythroid-derived 2)-like 2 (NRF2). H2S also influences the activity of the histone deacetylase protein family of sirtuins, which plays an important role in inhibiting oxidative stress in cardiomyocytes and during the aging process by modulating AOE gene expression. This review focuses on the role of H2S in NRF2 and sirtuin signaling pathways as they are related to cellular redox homeostasis.

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Hydrogen sulfide attenuates cardiac injury in takotsubo cardiomyopathy by alleviating oxidative stress

Cited by 44 publications

References 55 publications

Nitrosative Stress as a Modulator of Inflammatory Change in a Model of Takotsubo Syndrome

Nitrosative Stress as a Modulator of Inflammatory Change in a Model of Takotsubo Syndrome

International Expert Consensus Document on Takotsubo Syndrome (Part I): Clinical Characteristics, Diagnostic Criteria, and Pathophysiology

Role of Hydrogen Sulfide in NRF2- and Sirtuin-Dependent Maintenance of Cellular Redox Balance

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