2024
DOI: 10.3390/ph17050585
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Hydrogen Sulfide Delivery to Enhance Bone Tissue Engineering Cell Survival

Soheila Ali Akbari Ghavimi,
Trent J. Faulkner,
Rama Rao Tata
et al.

Abstract: Though crucial for natural bone healing, local calcium ion (Ca2+) and phosphate ion (Pi) concentrations can exceed the cytotoxic limit leading to mitochondrial overload, oxidative stress, and cell death. For bone tissue engineering applications, H2S can be employed as a cytoprotective molecule to enhance mesenchymal stem cell (MSC) tolerance to cytotoxic Ca2+/Pi concentrations. Varied concentrations of sodium hydrogen sulfide (NaSH), a fast-releasing H2S donor, were applied to assess the influence of H2S on MS… Show more

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