Hydrogen sulfide in signaling pathways

Olas, Beata

doi:10.1016/j.cca.2014.10.037

Cited by 161 publications

(108 citation statements)

References 117 publications

(174 reference statements)

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“…CBS, CSE, and CAT are pyridoxal 5-phosphate-dependent enzymes. CBS catalyzes the ␤-replacement of thiosulfides such as homocysteine to cysteine, whereas CSE catalyzes the ␣-and ␥-replacement of cysteine to H 2 S. CAT deaminates cysteine to mercaptopyruvate, which is followed by transulfuration catalyzed by the zinc-dependent enzyme 3-MST that results in biosynthesis of H 2 S. These pathways are elaborated in several excellent review articles (4,8,12,20,69,75,111,113,150) and summarized in Fig. 1.…”

mentioning

confidence: 99%

Emerging role of hydrogen sulfide-microRNA crosstalk in cardiovascular diseases

Hackfort

Mishra

2016

American Journal of Physiology-Heart and Circulatory Physiology

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mentioning

confidence: 99%

Emerging role of hydrogen sulfide-microRNA crosstalk in cardiovascular diseases

Hackfort

Mishra

2016

American Journal of Physiology-Heart and Circulatory Physiology

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“…Hydrogen sulfide (H 2 S) is a gaseous intracellular signal transducer involved in regulation of inflammation, apoptosis, oxidative stress and cell cycle, to name a few [138]. Due to its many important physiological functions, H 2 S has become a candidate for therapeutic intervention, primarily of diseases involving inflammatory reactions [139].…”

Section: Small Molecules Targeting Host Cellular Componentsmentioning

confidence: 99%

Recent Advances in the Development of Antiviral Therapeutics for Rift Valley Fever Virus Infection

Atkins

Freiberg

2017

Future Virol.

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Rift Valley fever virus (RVFV) is a mosquito-borne bunyavirus endemic to sub-Saharan Africa and the Arabian Peninsula and the etiological agent of Rift Valley fever. Rift Valley fever is a disease of major public health and economic concern, affecting livestock and humans. In ruminants, RVFV infection is characterized by high mortality rates in newborns and near 100% abortion rates in pregnant animals. Infection in humans is typically manifested as a self-limiting febrile illness, but can lead to severe and fatal hepatitis, encephalitis, hemorrhagic fever or retinitis with partial or complete blindness. Currently, there are no specific treatment options available for RVFV infection. This review presents a summary of the therapeutic approaches that have been explored on the treatment of RVFV infection.

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“…Although biologic gas such as H 2 S as principal gas molecule is responsible for causing halitosis, there are contradictory biological implications of three major biogas, nitric oxide (NO), H 2 S, and carbon monoxide (CO), in anti-inflammatory substances, promoting resolution of inflammatory processes, imposing several situations, including ischemic-reperfusion injury, cardioprotection, sepsis, hemostasis, fibrosis, pancreatitis, separately, but sometimes interacting each other [19,20]. Interestingly, H 2 S stands for dual functions, inflammatory mediator or anti-inflammatory mediator [21], gaseous intracellular transducer implicated in either abnormal pathology or normal physiology [22], positioning homeostasis as friend or foe [23]. H 2 S and their responsible enzymes, cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE), played good or bad, but ugly biological implications dependent on cellular context and disease conditions.…”

Section: Hydrogen Sulfide (H 2 S) Biogas: Good Bad Ugly In Its Biolmentioning

confidence: 99%

Helicobacter pylori Infection and Halitosis – Evidence, Hypothesis, and Korean Red Ginseng to Mitigate Its Effect

Han¹,

Park²,

Han³

et al. 2016

Extradigestive Manifestations of Helicobacter Pylori Infection - An Overview

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Halitosis is a common and ignored condition, but in some, it is a disease-associated health problem, suggestive of overt disease conditions and hasaffected about -% of world's population, bothering nonmedical social disturbance in many people. "lthough two kinds, pseudohalitosis and halitophobia, are also concerned, genuine halitosis originated from the oral cavity, such as gingivitis, caries, and poor oral hygiene, in % and the remaining % are extraoral sources of halitosis, which should not be ignored because of stigmata suggestive of overt tissue dysfunctions, for instance, poor nutrition and hygiene, alcohol abuse, smoking, and systemic illness such as chronic obstructive pulmonary disease, liver cirrhosis, diabetes mellitus, and chronic renal diseases. In this chapter, Helicobacter pylori H. pylori -associated halitosis as one of the extragastric manifestations is introduced. Since diagnostics of halitosis includes subjective methods examiner's sense of smell and objective methods instrumental analysis , under the hypothesis of a possible relationship between H. pylori infection and objective halitosis, the real levels of volatile sulfur compounds VSCs in the breath showed significant correlation between VSC levels and the degree of H. pylori-associated erosive gastritis as well as gastric cancer. These findings are further validated through either measuring H S level in gastric juices of H. pylori-infected gastritis or checking the expressions of cystathionine--lyase CSE and cystathionine--synthase C"S responsible for H S generation in biopsied stomach. The eradication of H. pylori significantly ameliorated halitosis, accompanied with significant reductions in gastric H S levels p< . . Korean red ginseng was very effective in either reducing H. pylori-associated H S or alleviating halitosis in patients with H. pylori-associated chronic atrophic gastritis. Conclusively, H. pylori infection demonstrates to have an important relationship with the development of halitosis, and its eradication could possibly promote the improvement of this condition.

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Hydrogen sulfide in signaling pathways

Cited by 161 publications

References 117 publications

Emerging role of hydrogen sulfide-microRNA crosstalk in cardiovascular diseases

Emerging role of hydrogen sulfide-microRNA crosstalk in cardiovascular diseases

Recent Advances in the Development of Antiviral Therapeutics for Rift Valley Fever Virus Infection

Helicobacter pylori Infection and Halitosis – Evidence, Hypothesis, and Korean Red Ginseng to Mitigate Its Effect

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