Hydrogen Sulfide

Is pharmacological, H2S-induced 'suspended animation' feasible in the ICU?

“…Finally, according to the currently available literature, neither inhalation of gaseous H 2 S nor injection of the soluble sulfide salts, NaSH or Na 2 S, is likely to become part of clinical practice because of damage to the airway mucosa and possibly toxic peak sulfide concentrations, respectively, but slow H 2 S-releasing molecules may enable these limitations to be overcome. Hence, there is “nothing rotten about hydrogen sulfide's medical promise” [50], and H 2 S clearly remains a “hot molecule” [51] in the field of research for a possible pharmacological induction of suspended animation-like hypometabolism.…”