Hydrogen Sulfide: Recent Progression and Perspectives for the Treatment of Diabetic Nephropathy

Sun, Hai-Jian; Wu, Zhiyuan; Cao, Lei; Zhu, Mengyuan; Liu, Tengteng; Guo, Lei; Lin, Yuanyuan; Nie, Xiaowei; Bian, Jin-Song

doi:10.3390/molecules24152857

Cited by 78 publications

(59 citation statements)

References 193 publications

(251 reference statements)

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“…The role of hydrogen sulfide in chronic and acute kidney disease is considered to be context-dependent [89,90]. The protective role of the metabolite was shown in models of ischemia-reperfusion and obstructive kidney injury [90], as well as in kidney impairments caused by diabetes and renovascular hypertension [91,92]. On the other hand, controversial data were obtained on the role of H 2 S, when using nephrotoxic cisplatin [89].…”

Section: Discussionmentioning

confidence: 99%

Microbiome-Metabolome Signature of Acute Kidney Injury

et al. 2020

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Intestinal microbiota play a considerable role in the host’s organism, broadly affecting its organs and tissues. The kidney can also be the target of the microbiome and its metabolites (especially short-chain fatty acids), which can influence renal tissue, both by direct action and through modulation of the immune response. This impact is crucial, especially during kidney injury, because the modulation of inflammation or reparative processes could affect the severity of the resulting damage or recovery of kidney function. In this study, we compared the composition of rat gut microbiota with its outcome, in experimental acute ischemic kidney injury and named the bacterial taxa that play putatively negative or positive roles in the progression of ischemic kidney injury. We investigated the link between serum creatinine, urea, and a number of metabolites (acylcarnitines and amino acids), and the relative abundance of various bacterial taxa in rat feces. Our analysis revealed an increase in levels of 32 acylcarnitines in serum, after renal ischemia/reperfusion and correlation with creatinine and urea, while levels of three amino acids (tyrosine, tryptophan, and proline) had decreased. We detected associations between bacterial abundance and metabolite levels, using a compositionality-aware approach—Rothia and Staphylococcus levels were positively associated with creatinine and urea levels, respectively. Our findings indicate that the gut microbial community contains specific members whose presence might ameliorate or, on the contrary, aggravate ischemic kidney injury. These bacterial taxa could present perspective targets for therapeutical interventions in kidney pathologies, including acute kidney injury.

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Section: Discussionmentioning

confidence: 99%

Microbiome-Metabolome Signature of Acute Kidney Injury

et al. 2020

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“…The major renal structural changes in DN include mesangial hyperplasia, thickening of the glomerular and tubular basement membrane, and glomerular sclerosis. The clinical manifestation of DN includes persistent proteinuria, increased blood pressure, and edema [18]. The causes of DN involve changes in renal hemodynamics, hypoxia and excessive activation of the renin-angiotensinaldosterone system (RAAS), oxidative stress, inflammation, mitochondrial dysfunction, podocyte autophagy, and genetic and epigenetic regulation [19].…”

Section: Pathophysiology Of Dnmentioning

confidence: 99%

Noncoding RNAs in Diabetic Nephropathy: Pathogenesis, Biomarkers, and Therapy

Mai

et al. 2020

Journal of Diabetes Research

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The correlation between diabetes and systematic well-being on human life has long established. As a common complication of diabetes, the prevalence of diabetic nephropathy (DN) has been increasing globally. DN is known to be a major cause of end-stage kidney disease (ESKD). Till now, the molecular mechanisms for DN have not been fully explored and the effective therapies are still lacking. Noncoding RNAs are a class of RNAs produced by genome transcription that cannot be translated into proteins. It has been documented that ncRNAs participate in the pathogenesis of DN by regulating inflammation, apoptosis, autophagy, cell proliferation, and other pathological processes. In this review, the pathological roles and diagnostic and therapeutic potential of three types of ncRNAs (microRNA, long noncoding RNA, and circular RNA) in the progression of DN are summarized and illustrated.

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“…Renal fibrosis is the ultimate pathological change of DKD. It is caused by a variety of mechanisms including renal hemodynamic changes, oxidative stress, inflammatory response, hypoxia, and activation of the renin-angiotensin-aldosterone system (RAAS) [ 9 , 10 ]. The kidney is a high metabolic organ; increasing evidence indicates that reactive oxygen species (ROS) overproduction is a common cause of kidney metabolic changes and hemodynamic changes [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Mitochondrial DNA: A New Predictor of Diabetic Kidney Disease

Huang

Chi

Wei

et al. 2020

International Journal of Endocrinology

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Diabetic kidney disease (DKD) is a common cause of end-stage renal disease, and diagnosis and treatment in time can help delay its progress. At present, there are more and more studies on the pathogenesis of DKD; mitochondrial dysfunction plays an important role in DKD. The occurrence and development of DKD is closely related to epigenetic changes and the interaction between mtDNA, ROS, inflammatory factors, and endothelial damage, which continuously aggravates kidney. The change of mtDNA is both the cause of DKD and the result of DKD. It is of great significance to incorporate the change of mtDNA into the monitoring of patients with diabetes. Existing evidence indicates that changes in mtDNA copy number in blood and urine reflect mitochondrial dysfunction and the severity of DKD. However, large-scale, long-term follow-up clinical trials are still needed to determine the threshold range. By the time, mitochondrial-targeted antioxidants will become a new method for the treatment of DKD and other diabetic complications; mtDNA also can be a therapeutic target for them.

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Hydrogen Sulfide: Recent Progression and Perspectives for the Treatment of Diabetic Nephropathy

Cited by 78 publications

References 193 publications

Microbiome-Metabolome Signature of Acute Kidney Injury

Microbiome-Metabolome Signature of Acute Kidney Injury

Noncoding RNAs in Diabetic Nephropathy: Pathogenesis, Biomarkers, and Therapy

Mitochondrial DNA: A New Predictor of Diabetic Kidney Disease

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