Hydrogen treatment: a novel option in liver diseases

Shi, Jian; Duncan, Brittany; Kuang, Xuyuan

doi:10.7861/clinmed.2020-0370

Cited by 10 publications

(6 citation statements)

References 41 publications

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“…Overall, these results indicate that G2-SUISO represents a simple and novel therapeutic strategy for NASH and NAFLD. Previous studies also showed that H 2 therapy is a very promising treatment of liver diseases and the rational use of it has already solved many problems clinically 47 . However, the current clinical delivery method of H 2 is not very convenient, and G2-SUISO can be made into capsules to solve this problem and facilitate H 2 administration.…”

Section: Discussionmentioning

confidence: 99%

Coral calcium carried hydrogen ameliorates the severity of non-alcoholic steatohepatitis induced by a choline deficient high carbohydrate fat-free diet in elderly rats

Nambu³

et al. 2023

Sci Rep

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Hydrogen has been reported to act as an antioxidant, anti-apoptosis and anti-inflammatory agent. Coral calcium carried hydrogen (G2-SUISO) is a safer and more convenient form of hydrogen agent than others. The mechanism underlying the hepatoprotective effects of G2-SUISO using an elderly non-alcoholic steatohepatitis (NASH) rat model was investigated. Two days after fasting, six-month-old elderly male F344/NSlc rats were given a choline deficient high carbohydrate fat-free (CDHCFF) diet from day 0 to day 3 as CDHCFF control group, and then switched to a normal diet from days 4 to 7 with or without 300 mg/kg G2-SUISO. Rats in each group were finally being sacrificed on day 3 or day 7. In the CDHCFF diet group, G2-SUISO decreased the liver weight-to-body weight ratio, the serum AST, ALT, total cholesterol levels, inflammatory infiltration, pro-inflammatory cytokine expression and lipid droplets with inhibiting lipogenic pathways by reducing sterol regulatory element-binding protein-1c, acetyl-CoA carboxylase and fatty acid synthase gene expression compared with the CDHCFF diet alone. G2-SUISO had beneficial effects of anti-apoptosis as well the down-regulation of pro-apoptotic molecules including NF-κB, caspase-3, caspase-9 and Bax. These findings suggest that G2-SUISO treatment exerts a significant hepatoprotective effect against steatosis, inflammation and apoptosis in elderly NASH rats.

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Section: Discussionmentioning

confidence: 99%

Coral calcium carried hydrogen ameliorates the severity of non-alcoholic steatohepatitis induced by a choline deficient high carbohydrate fat-free diet in elderly rats

Nambu³

et al. 2023

Sci Rep

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“…It has been reported that the balance between H 2 -producing and consuming bacteria is essential for normal H 2 cycling in the organs of mammals in order to prevent immune inflammatory reactions induced by pathogen infection. 24 According to a previous study, hydrogenase might instead utilize H 2 and release energy to boost the production of pathogenic-related proteins and enzymes that induced inflammation and necrosis that directly caused the liver lesions in mice. 25 We hypothesized that accumulation of H. hepaticus hydrogenase-oxidized H 2 to enhance virulence by producing high-efficiency solute uptake systems.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the mutant infection did not lead more severe hepatitis and liver fibrosis compared to WT H. hepaticus , suggesting that hydrogenase promoted H. hepaticus growth and virulence during infection. It has been reported that the balance between H 2 ‐producing and consuming bacteria is essential for normal H 2 cycling in the organs of mammals in order to prevent immune inflammatory reactions induced by pathogen infection 24 . According to a previous study, hydrogenase might instead utilize H 2 and release energy to boost the production of pathogenic‐related proteins and enzymes that induced inflammation and necrosis that directly caused the liver lesions in mice 25 .…”

Section: Discussionmentioning

confidence: 99%

Helicobacter hepaticus promotes liver fibrosis through oxidative stress induced by hydrogenase in BALB/c mice

Cao,

Zhang,

Bao

et al. 2023

Helicobacter

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BackgroundIt has been documented that Helicobacter hepaticus produces a nickel‐containing hydrogen‐oxidizing hydrogenase enzyme, which is necessary for hydrogen‐supported amino acid uptake. Although H. hepaticus infection has been shown to promote liver inflammation and fibrosis in BALB/c mice, the impact of hydrogenase on the progression of liver fibrosis induced by H. hepaticus has not been explored.Materials and MethodsBALB/c mice were inoculated with hydrogenase mutant (ΔHyaB) or wild type (WT) H. hepaticus 3B1 for 12 and 24 weeks. H. hepaticus colonization, hepatic histopathology, serum biochemistry, expression of inflammatory cytokines, and oxidative stress signaling pathways were detected.ResultsWe found that ΔHyaB had no influence on the colonization of H. hepaticus in the liver of mice at 12 and 24 weeks post infection (WPI). However, mice infected by ΔHyaB strains developed significantly alleviated liver inflammation and fibrosis compared with WT infection. Moreover, ΔHyaB infection remarkably increased the expression of hepatic GSH, SOD, and GSH‐Px, and decreased the liver levels of MDA, ALT, and AST compared to WT H. hepaticus infected group from 12 to 24 WPI. Furthermore, mRNA levels of Il‐6, Tnf‐α, iNos, Hmox‐1, and α‐SMA were significantly decreased with an increase of Nfe2l2 in the liver of mice infected by ΔHyaB strains. In addition, ΔHyaB H. hepaticus restored the activation of the Nrf2/HO‐1 signaling pathway, which is inhibited by H. hepaticus infection.ConclusionsThese data demonstrated that H. hepaticus hydrogenase promoted liver inflammation and fibrosis development mediated by oxidative stress in male BALB/c mice.

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“…c The timedependent ROC curves of 1-, 3-, and 5-year overall survival probabilities for HCC patients was predicted by nomogram (HBV) or C (HCV) virus, often result in liver cirrhosis, which is a critical risk factor for the progression of HCC [22][23][24][25]. And hepatitis infection is associated with not only liver disease but also thalassemia [26,27]. Chronic liver injury is associated with the abnormal regulation of hepatocytes growth, leading to dysplastic and regenerative nodules and tumorigenesis of HCC [25].…”

Section: Discussionmentioning

confidence: 99%

Human nuclear receptors (NRs) genes have prognostic significance in hepatocellular carcinoma patients

Sun

Shen

2021

World J Surg Onc

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Background Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality in the world. Method We downloaded the mRNA profiles and clinical information of 371 HCC patients from The Cancer Genome Atlas (TCGA) database. The consensus clustering analysis with the mRNA levels of 48 nuclear receptors (NRs) was performed by the “ConsensusClusterPlus.” The univariate Cox regression analysis was performed to predict the prognostic significance of NRs on HCC. The risk score was calculated by the prognostic model constructed based on eight optimal NRs. Then multivariate Cox regression analysis was performed to determine whether the risk score is an independent prognostic signature. Finally, the nomogram based on multiple independent prognostic factors was used to predict the long-term survival of HCC patients. Results The prognostic model constructed based on the eight optimal NRs (NR1H3, ESR1, NR1I2, NR2C1, NR6A1, PPARD, PPARG, and VDR) could effectively predict the prognosis of HCC patients as an independent prognostic signature. Moreover, the nomogram was constructed based on multiple independent prognostic factors including risk score and tumor node metastasis (TNM) stage and could better predict the long-term survival for 3- and 5-year of HCC patients. Conclusion Our results provided novel evidences that NRs could act as the potential prognostic signatures for HCC patients.

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Hydrogen treatment: a novel option in liver diseases

Cited by 10 publications

References 41 publications

Coral calcium carried hydrogen ameliorates the severity of non-alcoholic steatohepatitis induced by a choline deficient high carbohydrate fat-free diet in elderly rats

Coral calcium carried hydrogen ameliorates the severity of non-alcoholic steatohepatitis induced by a choline deficient high carbohydrate fat-free diet in elderly rats

Helicobacter hepaticus promotes liver fibrosis through oxidative stress induced by hydrogenase in BALB/c mice

Human nuclear receptors (NRs) genes have prognostic significance in hepatocellular carcinoma patients

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