Hydrogen water alleviates lung injury induced by one-lung ventilation

Wu, Qifei; Zhang, Jingyao; Wan, Yong; Song, Siyuan; Zhang, Yong; Zhang, Guangjian; Liu, Chang; Fu, Junke

doi:10.1016/j.jss.2015.06.017

Cited by 8 publications

(5 citation statements)

References 29 publications

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“…Mice were given water freely beginning on day 0, and the water vessel was refilled with fresh H 2 -rich or control water every day. The effect of administration of gefitinib alone or H 2 -rich water alone on normal lungs was described previously and no noticeable effect was observed [5,27]. Then, mice were randomly distributed into five groups as follows: Group 1, corn oil (vehicle) with control water; Group 2, naphthalene with control water; Group 3, naphthalene with H 2 -rich water; Group 4, naphthalene and gefitinib with control water; and Group 5, naphthalene and gefitinib with H 2 -rich water.…”

Section: Production Of H 2 -Rich Watermentioning

confidence: 74%

Molecular hydrogen attenuates gefitinib-induced exacerbation of naphthalene-evoked acute lung injury through a reduction in oxidative stress and inflammation

Terasaki

Suzuki

Tonaki

et al. 2019

Laboratory Investigation

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Although inhibition of epidermal growth factor receptor (EGFR)-mediated cell signaling by the EGFR tyrosine kinase inhibitor gefitinib is highly effective against advanced non-small cell lung cancer, this drug might promote severe acute interstitial pneumonia. We previously reported that molecular hydrogen (H 2) acts as a therapeutic and preventive antioxidant. Here, we show that treatment with H 2 effectively protects the lungs of mice from severe damage caused by oral administration of gefitinib after intraperitoneal injection of naphthalene, the toxicity of which is related to oxidative stress. Drinking H 2 −rich water ad libitum mitigated naphthalene/gefitinib-induced weight loss and significantly improved survival, which was associated with a decrease in lung inflammation and inflammatory cytokines in the bronchoalveolar lavage fluid. Naphthalene decreased glutathione in the lung, increased malondialdehyde in the plasma, and increased 4-hydroxy-2nonenal production in airway cells, all of which were mitigated by H 2-rich water, indicating that the H 2-rich water reverses cellular damage to the bronchial wall caused by oxidative stress. Finally, treatment with H 2 did not interfere with the antitumor effects of gefitinib on a lung cancer cell line in vitro or on tumor-bearing mice in vivo. These results indicate that H 2rich water has the potential to improve quality of life during gefitinib therapy by mitigating lung injury without impairing anti-tumor activity.

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Section: Production Of H 2 -Rich Watermentioning

confidence: 74%

Molecular hydrogen attenuates gefitinib-induced exacerbation of naphthalene-evoked acute lung injury through a reduction in oxidative stress and inflammation

Terasaki

Suzuki

Tonaki

et al. 2019

Laboratory Investigation

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“…As reported in some previous studies, the BAT or WAT of DIO mice behaves as a critical source of inflammation, giving rise to diabetic cardiomyopathy accompanied by obesity [ 30 , 31 , 32 ]. MHW intake has been reported to alleviate inflammation by reducing the protein levels of TNF-α and IL-1β in the rat injured lung through the inhibition of NF-kβ [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Drinking Molecular Hydrogen Water Is Beneficial to Cardiovascular Function in Diet-Induced Obesity Mice

Masuda

Sato

Miyata

et al. 2021

Biology

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Molecular hydrogen (MH) reportedly exerts therapeutic effects against inflammatory diseases as a suppressor of free radical chain reactions. Here, the cardiovascular protective effects of the intake of molecular hydrogen water (MHW) were investigated using high-fat diet-induced obesity (DIO) mice. MHW was prepared using supplier sticks and degassed water as control. MHW intake for 2 weeks did not improve blood sugar or body weight but decreased heart weight in DIO mice. Moreover, MHW intake improved cardiac hypertrophy, shortened the width of cardiomyocytes, dilated the capillaries and arterioles, activated myocardial eNOS-Ser-1177 phosphorylation, and restored left ventricular function in DIO mice. MHW intake promoted the histological conversion of hypertrophy to hyperplasia in white and brown adipose tissues (WAT and BAT) with the upregulation of thermogenic and cardiovascular protective genes in BAT (i.e., Ucp-1, Vegf-a, and eNos). Furthermore, the results of a colony formation assay of bone-marrow-derived endothelial progenitor cells (EPCs) indicated that MHW activated the expansion, differentiation, and mobilization of EPCs to maintain vascular homeostasis. These findings indicate that the intake of MHW exerts cardiovascular protective effects in DIO mice. Hence, drinking MHW is a potential prophylactic strategy against cardiovascular disorders in metabolic syndrome.

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“…By neutralizing reactive oxygen species (ROS), hydrogen can mitigate direct injuries to pulmonary parenchyma caused by external pathogens or toxins, thereby curbing the subsequent initiation of inflammatory cascades. 44,45 Additionally, hydrogen can modulate various inflammation-associated signaling pathways, such as inhibiting NF-κB activation to suppress the release of pro-inflammatory cytokines like TNF-α, IL-1β, and IL-6; 46 furthermore, inhibition of the MAPK pathway reduces pro-inflammatory cytokine release while regulating cell survival; 47,48 and inhibition of the PI3K/Akt pathway suppresses downstream inflammatory mediators and apoptotic proteins, potentially repairing the functionality of lung endothelial progenitor cells. 49 Moreover, by potentiating the Nrf2/HO-1 pathway, hydrogen induces antioxidant and cytoprotective genes, suppresses pro-inflammatory cytokine production, and mitigates oxidative stress.…”

Section: Mechanisms Of Hydrogen Therapymentioning

confidence: 99%