Hydrogen water ameliorates the severity of atopic dermatitis-like lesions and decreases interleukin-1β, interleukin-33, and mast cell infiltration in NC/Nga mice

Kajisa, Takuya; Yamaguchi, Takuji; Hu, Ailing; Suetake, Nobuhiro; Kobayashi, Hiroyuki

doi:10.15537/smj.2017.9.20807

Cited by 14 publications

(10 citation statements)

References 23 publications

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“…Molecular hydrogen has been shown to decrease the expression of various proinflammatory factors including interleukin (IL)-6, IL-1β, IL-10, IL-12, and tumor necrosis factor-α (TNF-α) [16,19]. This finding was supported in the clinical literature pertaining to HRW but not to the other forms of hydrogen-rich supplementation (transdermal or oral tablets) provided in the current report [8].…”

Section: Anti-inflammatorysupporting

confidence: 69%

A systematic literature review of the effects of molecular hydrogen during exercise

Sundararajan¹

2022

J Int Foot Ankle

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In the last decade, use of molecular hydrogen, through hydrogen-rich water (HRW), has become commonplace in the sports industry with anecdotal claims of improving athletic performance and endurance. Publications, clinical trials, and case studies have begun to emerge with the growing interest to clinically-validate the claims of improved performance and recovery in the athletic population. The objective of the current article is to review the recent literature to understand the effects of molecular hydrogen, through ingestion of hydrogen-rich water on muscles, joints, and athletic performance during the peri-exercise period. The following literature review documents the relevant effects identified within the included studies. A review of the studies published in the last ten years (2012-2022) pertaining to hydrogen-rich water (HRW) was performed. Using the PubMed search engine, the terms “hydrogen water” and “athlete” were searched. Quantitative data points pertaining to cardiorespiratory variables, blood markers, subject reported outcome measures, and athletic performance were identified from the included studies. Based on the aforementioned search criteria, one hundred and one articles were identified. Among these, fourteen studies pertained to the effects of molecular hydrogen during exercise. Of these studies, eleven studies reported the clinical findings associated with oral ingestion of liquid HRW and three studies identified observations pertaining to other hydrogen-rich applications in transdermal and tablet forms. The recent literature suggests that HRW may provide anti-inflammatory benefits as a neutralizing agent without evidence of side effects during high-intensity exercise in trained athletes. Consequently, when used during the peri-exercise period, HRW may be associated with anti-fatigue effects and improved athletic performance. The identified evidence supporting the use of HRW during the peri-exercise period is limited, and its extrapolation should be performed with caution. Despite the lack of significant high-quality evidence available in the recent literature, molecular hydrogen, through ingestion of HRW, has been adopted in the sports industry for its antioxidant, anti-inflammatory, and anti-fatigue properties identified in trained athletes, and it is used anecdotally to impact athletic performance without significant observed risk of side effects.

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Section: Anti-inflammatorysupporting

confidence: 69%

A systematic literature review of the effects of molecular hydrogen during exercise

Sundararajan¹

2022

J Int Foot Ankle

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“…Paraffin-embedded fixed tissue samples were stained with hematoxylin and eosin or toluidine blue following established protocols ( 28 ). Level of skin inflammation was assessed using skin thickness measurements, and analysis of inflammatory and mast cell numbers in lesional skin of OVA-induced AD-like skin lesions of Flii +/− , wild-type, and Flii Tg/Tg mice using high magnification images and light microscopy using optimized protocols using Image Pro-Plus 5.1 program (MediaCybernetics Inc.) as previously described ( 24 ).…”

Section: Methodsmentioning

confidence: 99%

Flightless I Alters the Inflammatory Response and Autoantibody Profile in an OVA-Induced Atopic Dermatitis Skin-Like Disease

et al. 2018

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Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disease characterized by excessive inflammation and disrupted skin barrier function. Although the etiology of AD is not completely understood, clinical and basic studies suggest increasing involvement of autoantibodies against intracellular proteins. An actin remodeling protein, Flightless I (Flii), has been shown to promote development of inflammatory mediated skin conditions and impairment of skin barrier development and function. Here, we sought to determine the effect of altering Flii expression on the development of AD and its contribution to autoimmune aspects of inflammatory skin conditions. Ovalbumin (OVA)-induced AD skin-like disease was induced in Flii heterozygous (Flii+/−), wild-type (Flii+/+), and Flii transgenic (FliiTg/Tg) mice by epicutaneous exposure to OVA for 3 weeks; each week was separated by 2-week resting period. Reduced Flii expression resulted in decreased disease severity and tissue inflammation as determined by histology, lymphocytic, and mast cell infiltrate and increased anti-inflammatory IL-10 cytokine levels and a marked IFN-γ Th1 response. In contrast, Flii over-expression lead to a Th2 skewed response characterized by increased pro-inflammatory TNF-α cytokine production, Th2 chemokine levels, and Th2 cell numbers. Sera from OVA-induced AD skin-like disease Flii+/− mice showed a decreased level of autoreactivity while sera from FliiTg/Tg mice counterparts showed an altered autoantibody profile with strong nuclear localization favoring development of a more severe disease. These findings demonstrate autoimmune responses in this model of OVA-induced AD-like skin disease and suggest that Flii is a novel target, whose manipulation could be a potential approach for the treatment of patients with AD.

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“…In many diseases, such as airway inflammation and cerebral ischemia, type I hypersensitivity caused by mast cell activation will aggravate the tissue congestion and edema [ 12 , 13 ]. H 2 inhibits the body's inflammatory response by inhibiting Th2 reaction to reduce mast cell activation as well [ 14 ]. H 2 can also regulate inflammation by regulating the physiological pathway of T cells.…”

Section: Mechanisms Of the Action Of Hmentioning

confidence: 99%

Hydrogen: A Novel Option in Human Disease Treatment

Yang

Dong

et al. 2020

Oxidative Medicine and Cellular Longevity

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H2 has shown anti-inflammatory and antioxidant ability in many clinical trials, and its application is recommended in the latest Chinese novel coronavirus pneumonia (NCP) treatment guidelines. Clinical experiments have revealed the surprising finding that H2 gas may protect the lungs and extrapulmonary organs from pathological stimuli in NCP patients. The potential mechanisms underlying the action of H2 gas are not clear. H2 gas may regulate the anti-inflammatory and antioxidant activity, mitochondrial energy metabolism, endoplasmic reticulum stress, the immune system, and cell death (apoptosis, autophagy, pyroptosis, ferroptosis, and circadian clock, among others) and has therapeutic potential for many systemic diseases. This paper reviews the basic research and the latest clinical applications of H2 gas in multiorgan system diseases to establish strategies for the clinical treatment for various diseases.

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Hydrogen water ameliorates the severity of atopic dermatitis-like lesions and decreases interleukin-1β, interleukin-33, and mast cell infiltration in NC/Nga mice

Cited by 14 publications

References 23 publications

A systematic literature review of the effects of molecular hydrogen during exercise

A systematic literature review of the effects of molecular hydrogen during exercise

Flightless I Alters the Inflammatory Response and Autoantibody Profile in an OVA-Induced Atopic Dermatitis Skin-Like Disease

Hydrogen: A Novel Option in Human Disease Treatment

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