Hydrogenated Coconut Oil and Tissue Fatty Acids in EFA-depleted and EFA-supplemented Rats

Williams, M. A.; Tamai, Katherine T.; Hincenbergs, I.; McIntosh, D. J.

doi:10.1093/jn/102.7.847

Cited by 36 publications

(11 citation statements)

References 28 publications

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“…The discrepancy between the results of our study and others may be related to the relative contents of HCO in the experimental diets used. The previous conclusion was based on experiments which were done primarily to obtain information on the relationship between the onset of external symptoms of EFA deficiency and tissue levels of EFAs in rat fed EFAD diets containing 25–30% HCO or in those fed a fat-free diet [15]. In the present study, the HCO diet contained only 4% HCO.…”

Section: Discussionmentioning

confidence: 91%

Early development of essential fatty acid deficiency in rats: Fat-free vs. hydrogenated coconut oil diet

Ling

Leon

et al. 2010

Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)

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This study examined the effects of feeding an essential fatty acid deficient (EFAD) diet either without fat or with added hydrogenated coconut oil (HCO) on fatty acid profiles in rats. Both diets induced equivalent biochemical evidence of EFAD reflected by the triene/tetraene ratio in plasma phospholipids within 2 weeks. However, the HCO diet led to larger increases of 16:1n7 and 18:1n9 in muscle but smaller increases in fat tissue and plasma triglycerides than the fat-free diet, suggesting greater increases in hepatic de novo lipogenesis with the latter. In addition, the HCO diet led to larger decreases of some 18:3n3 metabolites, particularly 22:6n3, in muscle, fat and brain tissues than the fat-free diet, presumably related to lesser stimulation of elongation and desaturation. Thus, these secondary effects of an EFAD diet on fatty acid metabolism can be modified by the saturated fat in the diet while the primary impact of both diets on development of EFAD is unaffected.

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Section: Discussionmentioning

confidence: 91%

Early development of essential fatty acid deficiency in rats: Fat-free vs. hydrogenated coconut oil diet

Ling

Leon

et al. 2010

Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)

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“…Also, composition of diets, gender, and age of animals all vary between studies. For example, use of a high-fat diet containing hydrogenated coconut oil, containing medium-chain fatty acids that are weakly bound to FABP1 ( 125 ), has been reported to be associated with reduced weight gain ( 126 ). Moreover, growth and sex steroid hormones regulate FABP1 expression during the entire life span.…”

Section: For Example Fabp1mentioning

confidence: 99%

Recent insights into the biological functions of liver fatty acid binding protein 1

Wang

Bonkovsky

Lemos

et al. 2015

Journal of Lipid Research

194

175

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“…However, the obesity phenotype observed by Martin et al has not been found by Newberry et al: In several studies, female mice were fed diets containing high amounts of medium chain FA (as hydrogenated coconut oil) and it was observed that LFABP −/− mice were resistant to obesity, gaining less weight and body fat than WT mice [83,89–91]. The resistance of this line of LFABP −/− mice to diet-induced obesity has been shown primarily, although not exclusively, on a high-fat diet containing hydrogenated coconut oil, which is likely to be deficient in the essential fatty acids linoleate and linolenate [92]. They also observed that female LFABP −/− mice were resistant to obesity and hepatic steatosis when fed a Western diet containing 41 kcal% butter fat, a source which is rich in long chain FA [83,88], however, no differences in body weight were found between these LFABP −/− and WT mice when females were fed diets containing high levels of polyunsaturated FA (41 kcal% safflower oil), or when fed diets containing high levels of trans unsaturated fats [89,93].…”

Section: Lfabp−/− Micementioning

confidence: 99%

Enterocyte fatty acid-binding proteins (FABPs): Different functions of liver and intestinal FABPs in the intestine

Gajda

Storch

2015

Prostaglandins, Leukotrienes and Essential Fatty Acids

162

126

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SUMMARY Fatty acid binding proteins (FABP) are highly abundant cytosolic proteins that are expressed in most mammalian tissues. In the intestinal enterocyte, both Liver- (LFABP; FABP1) and Intestinal-fatty acid binding proteins (IFABP; FABP2) are expressed. These proteins display high affinity binding for long chain fatty acids (FA) and other hydrophobic ligands, thus they are believed to be involved with uptake and trafficking of lipids in the intestine. In vitro studies have identified differences in ligand binding stoichiometry and specificity, and in mechanisms of FA transfer to membranes, and it has been hypothesized that LFABP and IFABP have difference functions in the enterocyte. Studies directly comparing LFABP- and IFABP-null mice have revealed markedly different phenotypes, indicating that these proteins indeed have different functions in intestinal lipid metabolism and whole body energy homeostasis. In this review, we discuss the evolving knowledge of the functions of LFABP and IFABP in the intestinal enterocyte.

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Hydrogenated Coconut Oil and Tissue Fatty Acids in EFA-depleted and EFA-supplemented Rats

Cited by 36 publications

References 28 publications

Early development of essential fatty acid deficiency in rats: Fat-free vs. hydrogenated coconut oil diet

Early development of essential fatty acid deficiency in rats: Fat-free vs. hydrogenated coconut oil diet

Recent insights into the biological functions of liver fatty acid binding protein 1

Enterocyte fatty acid-binding proteins (FABPs): Different functions of liver and intestinal FABPs in the intestine

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