This paper examined the efficiency of artificial neural network (ANN) and multivariate linear regression (MLR) models in the prediction of groundwater quality parameters such as ecological risk index (ERI), pollution load index (PLI), metal pollution index (MPI), Nemerow pollution index (NPI), and geoaccumulation index (Igeo). 40 groundwater samples were collected systematically and analyzed for mainly heavy metals. Results revealed that adopting measured parameters is effective in modeling the parameters with high level of accuracy. Contamination factor results reveal that Ni, Zn, Pb, Cd, and Cu have relatively low values <1 within the region while the Iron values ranged from low contamination to very high contamination (>6). PLI, MPI, and ERI results indicated low pollution. NPI results indicated that the majority of the samples were heavily polluted. Quantification of Contamination results revealed that most of the sample's quality was geogenically influenced. Igeo results revealed that most of the samples had extreme pollution. The health risk assessment results revealed that children are substantially prone to more health risk more than adults. The ANN and MLR models showed a high effective tendency in the prediction of ERI, PLI, MPI, NPI and Igeo. Principal Component Analysis results showed appreciable variable loadings while the Correlation matrix results reveal that there exists weak and positive correlation amongst elements. Based on the outcome of this study, this research recommends the use of ANN and MLR models in the prediction of groundwater quality parameters as they yielded positive, reliable, acceptable, and appropriate accuracy performances.