The Kunwari River Basin (KRB) needs effective management of water resources for sustainable agriculture and flood hazard mitigation. The Soil and Water Assessment Tool (SWAT), a semi distributed physically based model, was chosen and set up in the KRB for hydrologic modeling. SWAT-CUP (SWAT-Calibration and Uncertainty Programs) was used for model calibration, sensitivity and uncertainty analysis, following the Sequential Uncertainty Fitting (SUFI-2) technique. The model calibration was performed for the period (1987)(1988)(1989)(1990)(1991)(1992)(1993)(1994)(1995)(1996)(1997)(1998)(1999), with initial 3 years of warm up ; then, the model was validated for the subsequent 6 years of data (2000)(2001)(2002)(2003)(2004)(2005). To assess the competence of model calibration and uncertainty, two indices, the p-factor (observations bracketed by the prediction uncertainty) and the r-factor (achievement of small uncertainty band), were taken into account. The results Environ. Process. of SWAT simulations indicated that during the calibration the p-factor and the r-factor were reported as 0.82 and 0.76, respectively, while during the validation the p-factor and the r-factor were obtained as 0.71 and 0.72, respectively. After a rigorous calibration and validation, the goodness of fit was further assessed through the use of the coefficient of determination (R 2 ) and the Nash-Sutcliffe efficiency (NS) between the observed and the final simulated values. The results indicated that R 2 and NS were 0.77 and 0.74, respectively, during the calibration. The validation also indicated a satisfactory performance with R 2 of 0.71 and NS of 0.69. The results would be useful to the hydrological community, water resources managers involved in agricultural water management and soil conservation, as well as to those involved in mitigating natural hazards such as droughts and floods.