The Olivargas Reservoir is located in a remote and scarcely monitored area in the Odiel River Basin (Southwest Spain) and is used for domestic, agricultural and mining water supplies. In contrast with highly monitored reservoirs, this paper explores the application of the CE-QUAL-W2 model, that was designed by Cole and Wells in 2005, to a poorly monitored reservoir and the utility of the results obtained. The model satisfactorily reproduced the water head measured continuously over three years, temperature (T), total dissolved solids (TDS), dissolved oxygen (DO) and pH measured bimonthly in a depth profile near the dam. A significant increase in TDS and decrease in DO and pH profiles were observed for four months, especially in the hypolimnion. The model reproduced changes in the parameters by assuming the occurrence of an acid water spill into the reservoir. A comparison of calculated results and measured TDS and DO prompted the conclusion that the spill consisted of approximately 3000 t of TDS (mainly sulfates) and 26 t of Fe(II) flowing into the reservoir for approximately 15 days at rates of approximately two and 0.02 kg/s, respectively.Water 2017, 9, 613 2 of 15 applications are based on a broad understanding of reservoir geometry and time-series data on flow, temperature profiles and chemical and biological quality.Many small reservoirs (<50 hm 3 ), however, exist in remote and mountainous areas. They supply water to small communities, and there is rarely accurate monitoring or complete datasets on their physical, chemical and biological parameters. For such communities, water resource management is just as necessary, but the application of the conventional W2 can be challenging and has yet not been explored.The present work describes the calibration of the W2 model for a small reservoir with scarce monitoring in the upper basin of the Odiel River (in Southwest Spain). This region is known for its mining activity, and water from the reservoir is used for domestic consumption, agriculture and mining. As the only form of surveillance, a depth profile of temperature (T), electric conductivity (EC), dissolved oxygen (DO), pH and oxidation-reduction potential (ORP) was taken every two months close to the dam of the reservoir from June 2009 to December 2012. All these data were obtainable by the user without permanent stations or monitoring programs. Besides, an anomalous EC, DO and pH values were detected in one surveillance campaign and were attributed to a possible mining spill.For the reconstruction and evaluation of a possible pollution event, a W2 model was built and calibrated with the data from the bimonthly profiles. In contrast with the highly detailed models on highly monitored reservoirs, this paper explores the application of W2 to a poorly monitored reservoir and the utility of the results obtained.