Hydrolysable tannins as a potential therapeutic drug for the human fibrosis‐associated disease

Abstract

Fibrosis is a pathological change with abnormal tissue regeneration due to a response to persistent injury, which is extensively related to organ damage and failure, leading to high morbidity and mortality worldwide. Although the pathogenesis of fibrosis has been comprehensively elucidated, there are few effective therapies for treating fibrotic diseases. Natural products are increasingly regarded as an effective strategy for fibrosis with numerous favorable functions. Hydrolysable tannins (HT) are a type of natural products that have the potential to treat the fibrotic disease. In this review, we describe some biological activities and the therapeutic prospects of HT in organ fibrosis. Furthermore, the underlying mechanisms of inhibition of HT on fibrotic organs in relation to inflammation, oxidative stress, epithelial–mesenchymal transition, fibroblast activation and proliferation, and extracellular matrix accumulation are discussed. Understanding the mechanism of HT against fibrotic diseases will provide a new strategy for the prevention and attenuation of fibrosis progression.

Physicochemical Properties of Nanoliposomes Encapsulating Grape Seed Tannins Formed with Ultrasound Cycles

“…These molecules possess the ability to shield cells from oxidative stress induced by free radicals, which can have beneficial effects on health [2]. Recent research has unveiled the potential of tannins to safeguard the cardiovascular system by lowering blood pressure and enhancing blood circulation [3,4]. They can impede the production of pro-inflammatory substances in the body and induce apoptosis in cancer cells, rendering them intriguing natural bioactive molecules [5].…”

Genomic basis of the distinct biosynthesis of β‐glucogallin, a biochemical marker for hydrolyzable tannin production, in three oak species

“…This step is considered the crucial determinant for HT biosynthesis (Mittasch et al ., 2014). β‐glucogallin has potential roles in medicine and human healthcare, including protection against diabetes and related complications, retinopathy, glaucoma, inflammation, hepatic damage, skin damage from UV, and several solid tumors (Khan et al ., 2022; Wang & Cao, 2023). However, it is worth noting that HTs are not abundant in model plants such as Arabidopsis, tomato, and poplar.…”