Hydrolysis of linear DNA duplex catalyzed by Co(III) complex of cyclen attached to polystyrene

Jeung, Chul-Seung; Song, Jung Bae; Kim, Yong Hyun; Suh, Junghun

doi:10.1016/s0960-894x(01)00615-1

Cited by 38 publications

(30 citation statements)

References 18 publications

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“…Each of the three phenyl rings of the catalyst forms independent van der Waals contact with the side chain of Met (143), Pro (148), or Leu (149). Hydrogen bonds are formed between cyclen NÀ ÀH of CF and the carboxylate group of Glu(159) and between the ammonium group of the catalyst and the side chains of both Asp (144) and Gln (151).…”

Section: Bw Bx Bvmentioning

confidence: 99%

“…The authentic samples of CK or CL and the cleavage products obtained by the action of the angiotensin-cleaving agents produced identical quadrupole TOF MS, positively identifying CK and CL as the cleavage products. In previous studies, the Co(III) and the Cu(II) complexes of cyclen were used as catalytic centers for hydrolysis of peptide bonds as described above and for hydrolysis of phosphodiester bonds of DNA (143,144). It was surprising, therefore, that the compounds containing the Co(III) complex of cyclen cleaved angiotensins I and II by converting the N-terminal aspartate residue to pyruvate residue instead of hydrolyzing the peptide backbone.…”

Section: Oligopeptide-cleaving Catalysts Selective For Angiotensinmentioning

confidence: 99%

See 1 more Smart Citation

Peptide‐ or Protein‐Cleaving Agents Based on Metal Complexes

Chei¹,

Suh²

2007

Progress in Inorganic Chemistry

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Section: Bw Bx Bvmentioning

confidence: 99%

Section: Oligopeptide-cleaving Catalysts Selective For Angiotensinmentioning

confidence: 99%

Peptide‐ or Protein‐Cleaving Agents Based on Metal Complexes

Chei¹,

Suh²

2007

Progress in Inorganic Chemistry

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“…Sortino et al developed a self‐assembled monolayer on the gold surface, which could immobilize double‐strand DNA and could induce the cleavage of DNA upon light excitation 38. Suh and coworkers reported that cyclen metal complex and guanidinium group attached to poly(chloromethylstyrene‐ co ‐divinylbenzene) could remarkably enhanced its proteolytic activity via hydrolysis of phosphodiester linkage 33–37. In this study, we reported a kind of solid biomimetic catalyst by immobilization of Cu(II), Co(II), Ni(II) cyclen complex respectively, on Merrifield resin.…”

Section: Introductionmentioning

confidence: 88%

Immobilization cyclen copper (II) on merrifield resin: Efficient oxidative cleavage of plasmid DNA

Zhang

et al. 2008

J of Applied Polymer Sci

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Merrifield resin-supported cyclen (MRC) was directly prepared by attaching 1, 4, 7, 10-tetraazacyclododecane (cyclen) to Merrifield resin (MR). Subsequent coordination with Cu(II), Co(II), and Ni(II) gave immobilized cyclen complex MRC-Cu, MRC-Co, and MRC-Ni as ''solid artificial enzymes.'' These complexes were characterized by elemental analysis, IR spectroscopy, ICP-AES, and scanning electron microscopy (SEM). Furthermore, the DNA cleavage activities of these complexes were investigated by agarose gel electrophoresis.The results indicated that MRC-Cu was superior to other solid artificial enzymes, and the cleavage process was carried out via oxidative pathway. Moreover, the solid catalyst MRC-Cu was very stable and it could be reused at least four times without any loss of catalytic activity.

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“…Many researchers have been working hard to develop highly efficient and selective catalysts in order to achieve environmentally friendly and high-economy processes. A large number of studies on mimic hydrolytic metalloenzymes have used the metal ions cobalt(III) [3,4], cobalt(II) [5], copper(II) [6,7], zinc(II) [8,9], nickel(II) [10] and lanthanum(III) [11] etc. as the active center of the mimic system, respectively, but the manganese(III) complexes as the synthetic model of the metalloenzyme is infrequent.…”

Section: Introductionmentioning

confidence: 99%

PNPP Hydrolysis Catalyzed by Manganese(III) Complexes with Crowned Salicylaldimine Schiff Base Ligand

et al. 2005

Transition Met Chem

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Four manganese(III) complexes (MnL 1 Cl, MnL 2 Cl, MnL 4 2 Cl, MnL 5 2 Cl) with a crowned salicylaldimine Schiff base ligand have been synthesized and employed as models to mimic hydrolase in the hydrolysis of p-nitrophenyl picolinate (PNPP). The kinetics and mechanism of catalytic PNPP hydrolysis have been investigated. The kinetic mathematical model of PNPP cleavage catalyzed by these complexes has been proposed. The effects of the ligand structure and crown ether ring in complexes, and the reactive temperature on the rate of catalytic PNPP hydrolysis have been also examined. The results show that compared with the crown-free analogous MnL 3 Cl and MnL 6 2 Cl, the crowned Schiff base manganese(III) complexes, MnL 1 Cl, MnL 2 Cl, MnL 4 2 Cl and MnL 5 2 Cl, exhibit more high catalytic activity, which follow the order: MnL 1 Cl >MnL 2 Cl >MnL 4 2 Cl >MnL 5 2 Cl >MnL 3 Cl >MnL 6 2 Cl; the pseudo-first-order-rate (k obs ) for the PNPP hydrolysis catalyzed by the complex MnL 1 Cl containing three crown ether rings is highest among six complexes and is 1.81 times that of MnL 3 Cl, 1.49 · 10 3 times that of spontaneous hydrolysis of PNPP, respectively, at pH = 7.00, [S] = 2.0 · 10 )4 mol dm )3 .

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Hydrolysis of linear DNA duplex catalyzed by Co(III) complex of cyclen attached to polystyrene

Cited by 38 publications

References 18 publications

Peptide‐ or Protein‐Cleaving Agents Based on Metal Complexes

Peptide‐ or Protein‐Cleaving Agents Based on Metal Complexes

Immobilization cyclen copper (II) on merrifield resin: Efficient oxidative cleavage of plasmid DNA

PNPP Hydrolysis Catalyzed by Manganese(III) Complexes with Crowned Salicylaldimine Schiff Base Ligand

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