Hydrolysis of phytosterol esters in the intestine is required for their cholesterol lowering effects

Mild and Efficient Preparation of Phytosteryl Amino Acid Ester Hydrochlorides and Their Emulsifying Properties

“…Therefore, it is feasible to conjugate some beneficial molecules to phytosterols to improve their solubility and bioavailability. For example, esterification of phytosterols with various fatty acids could significantly enhance their lipid solubility and retain their biological activity, − and these phytosteryl esters are hydrolyzed in the intestine to play the role of lowering cholesterol . Recently, some researchers have attempted to prepare emulsified water-soluble phytosterols, which could potentially increase their absorption, show improved effects on cholesterol and lipid profile, and indicate increased dose response in food systems. − However, oil-in-water phytosterol microemulsions, nanodispersions, and nanoliposomes are limitedly used in food products because of their poor stability, which affects the product quality. , Improving water solubility of bioactives can accelerate the speed of going into the tissues and enhance the absorbance rate in the body.…”