Hydrolytic cleavage of nerve agent simulants by gold nanozymes

Lyu, Yanchao; Morillas-Becerril, Lucía; Mancin, Fabrizio; Scrimin, Paolo

doi:10.1016/j.jhazmat.2021.125644

Cited by 19 publications

(14 citation statements)

References 47 publications

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“…However, the binding of the nucleobase to a nearby Zn(II) complex makes it unavailable for cooperating in the cleavage of the substrate. We have shown that phosphate diesters (but not triesters) [23] cleavage by TACN−Zn(II) complexes requires a dinuclear catalytic site [10,12,18,19] . As the concentration of UPNP increases, dinuclear catalytic sites become less and less available and the catalytic performance of the catalyst decreases (downward curvature of the graph of Figure 2A).…”

Section: Resultsmentioning

confidence: 95%

The Mechanism of Cleavage of RNA Phosphodiesters by a Gold Nanoparticle Nanozyme

Czescik

Mancin

Strömberg

et al. 2021

Chemistry A European J

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The cleavage of uridine 3'-phosphodiesters bearing alcohols with pK a ranging from 7.14 to 14.5 catalyzed by AuNPs functionalized with 1,4,7-triazacyclononane-Zn(II) complexes has been studied to unravel the source of catalysis by these nanosystems (nanozymes). The results have been compared with those obtained with two Zn(II) dinuclear catalysts for which the mechanism is fairly understood. Binding to the Zn(II) ions by the substrate and the uracil of uridine was observed. The latter leads to inhibition of the process and formation of less productive binding complexes than in the absence of the nucleobase. The nanozyme operates with these substrates mostly via a nucleophilic mechanism with little stabilization of the pentacoordinated phosphorane and moderate assistance in leaving group departure. This is attributed to a decrease of binding strength of the substrate to the catalytic site in reaching the transition state due to an unfavorable binding mode with the uracil. The nanozyme favors substrates with better leaving groups than the less acidic ones.

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Section: Resultsmentioning

confidence: 95%

The Mechanism of Cleavage of RNA Phosphodiesters by a Gold Nanoparticle Nanozyme

Czescik

Mancin

Strömberg

et al. 2021

Chemistry A European J

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“…An understanding of what happens at the catalytic site during the chemical transformation of the substrate allows one to design evolved generations of catalysts. Furthermore, the combinatorial approach permitted by the self-assembled nature of the monolayer passivated AuNPs may enable one to combine rational design with the selection of relatively large pools of catalysts. We are confident that this will allow, in a relatively short time, to further narrow (or even close) the gap in kinetic performance between natural enzymes and these nanozymes.…”

Section: Discussionmentioning

confidence: 99%

Mimicking Enzymes: The Quest for Powerful Catalysts from Simple Molecules to Nanozymes

Lyu

Scrimin

2021

ACS Catal.

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“…[7] These nanozymes have been demonstrated to show peroxidase-, catalase-, superoxide dismutase-, oxidase-, hydrolase-, lyase-, or isomerase-like catalytic activities. [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] With the outstanding advantages of low costs, high stability, large-scale production, and long storage times, nanozymes have widely been applied in the area of biomedicine, such as cancer theranostics, [27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44] antimicrobial treatments, [45][46][47][48][49][50][51][52][53] detoxification, [54]…”

Section: Introductionmentioning

confidence: 99%

“…The report of Fe 3 O 4 nanoparticles showing horseradish peroxidase like activity has led to a series of nanozymes having been constructed [7] . These nanozymes have been demonstrated to show peroxidase‐, catalase‐, superoxide dismutase‐, oxidase‐, hydrolase‐, lyase‐, or isomerase‐like catalytic activities [8–26] . With the outstanding advantages of low costs, high stability, large‐scale production, and long storage times, nanozymes have widely been applied in the area of biomedicine, such as cancer theranostics, [27–44] antimicrobial treatments, [45–53] detoxification, [54–57] and cytoprotection [58–66] .…”

Section: Introductionmentioning

confidence: 99%

Chiral Nanozymes for Enantioselective Biological Catalysis

Dong

Ren

et al. 2022

Angewandte Chemie

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As a neat combination of the characteristics of enzymatic activity and nanomaterials, nanozymes have attracted much attention. Although tremendous effort has been devoted to developing nanozymes with high catalytic activity, substrate selectivity is often overlooked in the construction of nanozymes. With their subtly evolving structures, natural enzymes generally possess high selectivity for chiral substrates which play important roles in biosynthesis and biomedical applications. However, the rational construction of nanozymes with high enantioselectivity remains a significant challenge. In this Minireview, we provide an overview of recent advances in strategies for the synthesis of chiral nanozymes and their enantioselective biological catalysis. We further focus on current challenges, potential solutions, and future developing trends of chiral nanozyme-based enantioselective biological catalysis. There is plenty of room to explore. This Minireview will provide new insights into the development of chiral nanozymes and their applications.

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Hydrolytic cleavage of nerve agent simulants by gold nanozymes

Cited by 19 publications

References 47 publications

The Mechanism of Cleavage of RNA Phosphodiesters by a Gold Nanoparticle Nanozyme

The Mechanism of Cleavage of RNA Phosphodiesters by a Gold Nanoparticle Nanozyme

Mimicking Enzymes: The Quest for Powerful Catalysts from Simple Molecules to Nanozymes

Chiral Nanozymes for Enantioselective Biological Catalysis

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