Hydrolytic degradation and protein release studies of thermogelling polyurethane copolymers consisting of poly[(R)-3-hydroxybutyrate], poly(ethylene glycol), and poly(propylene glycol)

Loh, Xian Jun; Goh, S. H.; Li, Jun

doi:10.1016/j.biomaterials.2007.05.016

Cited by 201 publications

(202 citation statements)

References 37 publications

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“…Due to control of the gel formulation and polymer composition, the release duration of the protein from 20 to 80 days was successfully demonstrated (Figures 14c, d). 71 In addition, the cell growth on the PHB/PEG/ PPG poly(ether ester urethane)s hydrogel surface exhibited a typical spindle-like fibroblast morphology; a healthy morphology was maintained after 72 h of incubation. Conversely, the hydrophilic surface of F127 gels inhibited the growth of cells for longer time periods, which suggests that the incorporation of the PHB segment in PHB/PEG/PPG poly(ether ester urethane)s copolymers significantly increased the hydrophobicity of the gel surface, which enhances the cell adhesion capability and facilitates cell growth.…”

Section: Modified Phas As Engineering Materials Z LI Et Almentioning

confidence: 94%

“…69,70 The hydrolytic degradation of PHB/PEG/PPG poly(ether ester urethane) hydrogels was characterized by an initial incubation period, followed by the erosion of the polymer gel and the random chain scission of the ester bonds in PHB segments. 71 The relationship between the protein release and the hydrogel degradation process was also correlated. Due to control of the gel formulation and polymer composition, the release duration of the protein from 20 to 80 days was successfully demonstrated (Figures 14c, d).…”

Section: Modified Phas As Engineering Materials Z LI Et Almentioning

confidence: 99%

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Polyhydroxyalkanoates: opening doors for a sustainable future

2016

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Polyhydroxyalkanoates (PHAs) comprise a group of natural biodegradable polyesters that are synthesized by microorganisms. However, several disadvantages limit their competition with traditional synthetic plastics or their application as ideal biomaterials. These disadvantages include their poor mechanical properties, high production cost, limited functionalities, incompatibility with conventional thermal processing techniques and susceptibility to thermal degradation. To circumvent these drawbacks, PHAs need to be modified to ensure improved performance in specific applications. In this review, well-established modification methods of PHAs are summarized and discussed. The improved properties of PHA that blends with natural raw materials or other biodegradable polymers, including starch, cellulose derivatives, lignin, poly(lactic acid), polycaprolactone and different PHA-type blends, are summarized. The functionalization of PHAs by chemical modification is described with respect to two important synthesis approaches: block copolymerization and graft copolymerization. The expanded utilization of the modified PHAs as engineering materials and the biomedical significance in different areas are also addressed.

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Section: Modified Phas As Engineering Materials Z LI Et Almentioning

confidence: 94%

Section: Modified Phas As Engineering Materials Z LI Et Almentioning

confidence: 99%

Polyhydroxyalkanoates: opening doors for a sustainable future

2016

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“…A thermosensitive and amphiphilic poly(ether ester urethane) multiblock copolymer consisting of PHB, PEG, and poly(propylene glycol) (PPG) (PEG/PPG/PHB) was synthesized. [47,48] This copolymer, in aqueous solutions and at very low concentrations (2-5 wt.-%). showed a sol-to-gel transition as a function of temperature change.…”

Section: Poly(ethylene Glycol) (Peg)/polyestermentioning

confidence: 99%

“…PLGA Chondrocyte MPEG-PCL rBMSC, dexamethasone [104] FITC-BSA, BSA [105,106] Cholesterol end-capped star PEG-PLLA L929 cells [46] PEG/PPG/PHB BSA [48] Polyphosphazenes FITC-dextran, HSA [107] Doxorubicin, paclitaxel [108,112] FITC-albumin [109] Pancreatic islets, hepatocytes [110,111] C/GP Camptothecin, insulin [113,114] Bovine chondrocytes [115] pH/temperature-sensitive OSM-PCLA-PEG-PCLA-OSM Paclitaxel [116] hMSCs [117] PAE-PCL-PEG-PCL-PAE Insulin [82,118] (PCL-PEG-PCL-PAU) n Paclitaxel [86] (PEG-PAU) m Chlorambucil [87] PAA-PEG-PAA Flurbiprofen [90] PAE-PEG-PAE Lidocaine [89] matrices or cell growth depots. Table 1 summarizes the biomedical applications of the biodegradable injectable hydrogels.…”

Section: Hydrogel Types Polymer Delivery/applications Referencesmentioning

confidence: 99%

“…The PEG/PPG/PHB hydrogel is a promising candidate for the controlled release of protein. [48] The in vitro release of BSA was controllable over 70 d. Diffusion control was proposed as the release mechanism during the first stage of release, and the mechanism at the later stages was proposed to be erosion control. Polyphosphazenes were used for the sustained release of FITC-dextran and human serum albumin (HSA) over the course of two weeks.…”

Section: Temperature-sensitive Block Copolymer Hydrogelsmentioning

confidence: 99%

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Injectable Biodegradable Hydrogels

Nguyen

Lee

2010

Macromolecular Bioscience

422

343

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Injectable biodegradable copolymer hydrogels, which exhibit a sol–gel phase transition in response to external stimuli, such as temperature changes or both pH and temperature (pH/temperature) alterations, have found a number of uses in biomedical and pharmaceutical applications, such as drug delivery, cell growth, and tissue engineering. These hydrogels can be used in simple pharmaceutical formulations that can be prepared by mixing the hydrogel with drugs, proteins, or cells. Such formulations are administered in a straightforward manner, through site‐specific control of release behavior, and the hydrogels are compatible with biological systems. This review will provide a summary of recent progress in biodegradable temperature‐sensitive polymers including polyesters, polyphosphazenes, polypeptides, and chitosan, and pH/temperature‐sensitive polymers such as sulfamethazine‐, poly(β‐amino ester)‐, poly(amino urethane)‐, and poly(amidoamine)‐based polymers. The advantages of pH/temperature‐sensitive polymers over simple temperature‐sensitive polymers are also discussed. A perspective on the future of injectable biodegradable hydrogels is offered.magnified image

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Block Copolymer Hydrogels

Gao

Lee

2012

Encyclopedia of Polymer Science and Technology

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Block copolymer hydrogels are three‐dimensional polymeric networks that can absorb a considerable amount of water to maintain their semisolid morphology. Chemically cross‐linked hydrogels which can be prepared through disulfide bond formation, photopolymerization, or click chemistry, exhibit a nonreversible phase transition state. In contrast, physically cross‐linked hydrogels can be formed via self‐assembly of amphiphilic block copolymers, in response to environmental stimuli, including pH and/or temperature, and show a sol‐gel phase transition. Importantly, these stimuli‐sensitive physical hydrogels can exist as a sol state prior to administration, and subsequently translate to a gel state after administration under the human body condition. Consequently, the stimuli‐sensitive hydrogels have attracted significant interest for their potential applications in the site‐specific pharmaceutical (drug/protein) delivery and tissue regeneration. The article focuses on synthesis, properties, and biomedical applications of stimuli‐responsive block copolymer hydrogels that exhibit a reversible sol‐gel phase transition in response to temperature, pH, pH/temperature, and other stimulus conditions.

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Hydrolytic degradation and protein release studies of thermogelling polyurethane copolymers consisting of poly[(R)-3-hydroxybutyrate], poly(ethylene glycol), and poly(propylene glycol)

Cited by 201 publications

References 37 publications

Polyhydroxyalkanoates: opening doors for a sustainable future

Polyhydroxyalkanoates: opening doors for a sustainable future

Injectable Biodegradable Hydrogels

Block Copolymer Hydrogels

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