Hydrolytic reactivity of novel copper(II) complexes with reduced N-salicylate threonine Schiff bases: distinguishable effects of various micelles

Micelle-modulated reactivity of novel copper(ii) complexes with reduced l-histidine Schiff bases as mimic carboxylesterases

“…The actual concentration of active species in the 2 -containing catalytic system is higher than that of 1 , and thereby 2 presented better activity over 1 . Compared to PNPP spontaneous hydrolysis, 12 both 1 and 2 arouse obvious rate increases by three orders of magnitude (Fig. 4A and B) in catalyzing PNPP hydrolysis.…”

“…To overcome their intrinsic drawbacks, over the years, chemists have been attempting to develop some artificial hydrolases to mimic catalytic functions of natural carboxylesterases. [9][10][11][12][13][14][15][16][17] Histidine residues within the structures of natural hydrolase not only act as nucleophilic groups but also serve as general acid-base catalytic groups, and take part in some enzyme reactions through acid-base catalysis and covalent catalysis. 18,19 Imidazole derivatives with extensive conjugated systems facilitate electron transfer.…”

“…To overcome their intrinsic drawbacks, over the years, chemists have been attempting to develop some artificial hydrolases to mimic catalytic functions of natural carboxylesterases. 9–17…”