Hydrolytic stability of polylactide stereocomplex microparticles containing metal ions

Wojtczak, Edyta; Biedroń, Tadeusz; Bednarek, Melania

doi:10.1007/s00289-018-2432-9

Cited by 13 publications

(5 citation statements)

References 44 publications

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“…The progress of hydrolytic degradation of the polymer during the exposure of PLA stereocomplex microparticles to phosphate buffer solution can be supported by the results of our earlier study on stereocomplex microparticle susceptibility to hydrolysis. 64 That study, performed during a similar period of time, showed a decrease in PLA molecular weight, a decrease in polymer melting temperature and changes in its crystallinity.…”

Section: In Vitro Release Of Vitamins D 3 and Ementioning

confidence: 73%

Encapsulation of hydrophobic vitamins by polylactide stereocomplexation and their release study

Wojtczak

Gadzinowski

Makowski

et al. 2018

Polymer International

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Among different drug‐containing formulations prepared from biodegradable polymers, those based on polylactide (PLA) (usually block copolymers with poly(ethylene glycol)) are the most frequently developed and improved. A new easy method of such drug delivery system preparation with the application of PLA stereocomplexation is presented. The encapsulation of hydrophobic vitamins such as D3, E and A by spontaneous precipitation of microparticles with an average diameter of 1–2 µm led to a loading of about 10 wt% and an encapsulation efficiency in the range 27%–45% when a vitamin:PLA weight ratio of 3:10 was applied. SEM, TEM, X‐ray photoelectron spectroscopy and nitrogen absorption analysis of neat and vitamin‐loaded microparticles indicate a porous structure of the microparticles and confirm the presence of vitamins inside with an enriched surface layer. The release of vitamins into a phosphate buffer (pH 7.4) at 37 °C takes place at a low rate according to almost zero‐order kinetics (35%–60% of vitamin over 4 weeks). © 2018 Society of Chemical Industry

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Section: In Vitro Release Of Vitamins D 3 and Ementioning

confidence: 73%

Encapsulation of hydrophobic vitamins by polylactide stereocomplexation and their release study

Wojtczak

Gadzinowski

Makowski

et al. 2018

Polymer International

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“…Both PLLA and PDLA have different degradation times. 139,140 PLLA (T g ∼ 63 °C) has slower degradation compared to PDLA (T g ∼ 55 °C) due to a higher glass transition temperature.…”

Section: Biodegrdation Of Classified Biopolymers Used In Industrial A...mentioning

confidence: 99%

A Critical Review of the Performance and Soil Biodegradability Profiles of Biobased Natural and Chemically Synthesized Polymers in Industrial Applications

Tyagi

Agate

Velev

et al. 2022

Environ. Sci. Technol.

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This review explores biobased polymers for industrial applications, their end fate, and most importantly, origin and key aspects enabling soil biodegradation. The physicochemical properties of biobased synthetic and natural polymers and the primary factors governing degradation are explored. Current and future biobased systems and factors allowing for equivalent comparisons of degradation and possible sources for engineering improved biodegradation are reviewed. Factors impacting ultraviolet (UV) stability of biopolymers have been described including methods to enhance photoresistance and impact on biodegradation. It discusses end-fate of biopolymers in soil and impact of residues on soil health. A limited number of studies examine side effects (e.g., microbial toxicity) from soil biodegradation of composites and biopolymers. Currently available standards for biodegradation and composting have been described with limitations and scope for improvements. Finally, design considerations and implications for sustainable polymers used, under consideration, and to be considered within the context of a rational biodegradable strategy are elaborated.

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“…This study focused on enzymatic hydrolysis as a degradation mechanism by investigation of the degradation of PNPs with various crystallinities. Compared with previous studies [ 18 , 19 , 20 , 21 , 22 , 23 ], polymers with a constant level of hydrophilicity were used. The aliphatic polyester used in this current study, polylactide ([C 6 H 8 O 4 ] n , PLA), undergoes biodegradation via hydrolysis into non-toxic byproducts such as lactic acid and primarily degrades through bulk erosion [ 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Stereocomplexation and Crystallinity on the Degradation of Polylactide Nanoparticles

Yin,

Hemstedt,

Scheuer

et al. 2024

Nanomaterials

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Polymeric nanoparticles (PNPs) are frequently researched and used in drug delivery. The degradation of PNPs is highly dependent on various properties, such as polymer chemical structure, size, crystallinity, and melting temperature. Hence, a precise understanding of PNP degradation behavior is essential for optimizing the system. This study focused on enzymatic hydrolysis as a degradation mechanism by investigation of the degradation of PNP with various crystallinities. The aliphatic polyester polylactide ([C3H4O2]n, PLA) was used as two chiral forms, poly l-lactide (PlLA) and poly d-lactide (PdLA), and formed a unique crystalline stereocomplex (SC). PNPs were prepared via a nanoprecipitation method. In order to further control the crystallinity and melting temperatures of the SC, the polymer poly(3-ethylglycolide) [C6H8O4]n (PEtGly) was synthesized. Our investigation shows that the PNP degradation can be controlled by various chemical structures, crystallinity and stereocomplexation. The influence of proteinase K on PNP degradation was also discussed in this research. AFM did not reveal any changes within the first 24 h but indicated accelerated degradation after 7 days when higher EtGly content was present, implying that lower crystallinity renders the particles more susceptible to hydrolysis. QCM-D exhibited reduced enzyme adsorption and a slower degradation rate in SC-PNPs with lower EtGly contents and higher crystallinities. A more in-depth analysis of the degradation process unveiled that QCM-D detected rapid degradation from the outset, whereas AFM exhibited delayed changes of degradation. The knowledge gained in this work is useful for the design and creation of advanced PNPs with enhanced structures and properties.

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Hydrolytic stability of polylactide stereocomplex microparticles containing metal ions

Cited by 13 publications

References 44 publications

Encapsulation of hydrophobic vitamins by polylactide stereocomplexation and their release study

Encapsulation of hydrophobic vitamins by polylactide stereocomplexation and their release study

A Critical Review of the Performance and Soil Biodegradability Profiles of Biobased Natural and Chemically Synthesized Polymers in Industrial Applications

The Effect of Stereocomplexation and Crystallinity on the Degradation of Polylactide Nanoparticles

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