Hydrolyzable tannins from hydroalcoholic extract from Poincianella pluviosa stem bark and its wound-healing properties: Phytochemical investigations and influence on in vitro cell physiology of human keratinocytes and dermal fibroblasts

Bueno, Fernanda; Panizzon, Gean Pier; Mello, Eneri Vieira Souza de Leite; Lechtenberg, Matthias; Petereit, Frank; Mello, João Carlos Palazzo de; Hensel, Andreas

doi:10.1016/j.fitote.2014.10.007

Cited by 51 publications

(36 citation statements)

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“…Compounds 1, 3 and 5 were previously identified in extracts of flowers and bark of P. pluviosa by ESI-MS/MS analyses. 15 The presence of flavonoids 7, 8, 9 and 10 in Poincianella is reported here for the first time. Structures of the compounds isolated from the ethyl acetate fractions (P1-A and P2-A) are depicted in Figure 2.…”

Section: Chemical Studymentioning

confidence: 57%

“…41 It seems plausible to suppose that ellagic acid may be responsible for the antimalarial activity of the bark as well, since this compound has already been detected in the bark extract. 15 From a mechanistic point of view, several studies suggest that ellagic acid (1) inhibits important enzymes necessary for the development of Plasmodium, such as plasmepsin II, β-hematin or glutathione-S-transferase. 45,49 Studies have shown that the inhibitory effect of ellagic acid on plasmepsin II was not the main mechanism.…”

Section: Biological Studymentioning

confidence: 99%

“…The stem bark from the tree presents antidiarrheal, wound healing and antimalarial therapeutic properties. [14][15][16] More specifically, Tacana Indians living in the Amazonian Bolivian forest use decoction of the stem bark from P. pluviosa for diarrhea and dysentery. Phenolic compounds and terpenoids were reported in flowers and stem bark from P. pluviosa.…”

Section: Introductionmentioning

confidence: 99%

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Leaves from the Tree Poincianella pluviosa as a Renewable Source of Antiplasmodial Compounds against Chloroquine-Resistant Plasmodium falciparum

Souza¹,

Nascimento²,

Borsodi³

et al. 2017

J. Braz. Chem. Soc.

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Poincianella pluviosa is a tree whose stem bark is reputed to have antidiarrheal, wound healing, antitumoral and antimalarial properties. Considering that the leaves of the tree are a more abundant and renewable source than the stem bark, we chose to study the antimalarial potential of this organ part. The aqueous leaf extract exhibited a rich phenolic profile. It was active (IC 50 = 6.88 ± 1.64 µg mL -1 ) against chloroquine resistant Plasmodium falciparum (W2) without toxicity to HepG2 A16 cells. The organic fraction was more active (IC 50 = 1.83 µg mL -1 ) than the aqueous leaf extract itself. Ten phenolic compounds were obtained from the latter. This is the first report on the phenolic composition of P. pluviosa leaves. Ellagic acid (IC 50 = 0.215 ± 0.007 µg mL -1 ) proved to be 32 fold more active than the aqueous leaf extract itself. Considering their renewable aspect, leaves of P. pluviosa appear to be a more interesting source of antimalarial compounds than stem bark.Keywords: Poincianella pluviosa var. peltophoroides, leaves, ellagic acid, malaria, Plasmodium falciparum (W2) IntroductionA reduction in the incidence of tropical diseases such as malaria in poor countries is considered a major goal of the international community.1,2 In 2013, malaria was reported to be a threat to 198 million people causing 584,000 deaths in the world, mostly children under 5 years old in Africa. The impact of this disease is a major risk with the growth of world's population, mainly in regions without access to health services. The lack of sufficient financial resources and public health capacities in poor endemic countries led to the use of inefficient medicines and/or protocols resulting in an increase of mortality rate and spread of parasite resistance. 2,3 Malaria is an infectious disease caused by protozoa of the genus Plasmodium, which is transmitted by female Anopheles sp. mosquitoes. Five species of Plasmodium are able to infect humans, Plasmodium falciparum being considered the most dangerous. 4 Some clinical manifestations such as fever, chills, mild anemia and diarrheas are associated with malaria. 3,5 According to World Health Organization (WHO)-established protocols, 2 the treatment of uncomplicated Plasmodium falciparum malaria involves artemisininbased combination therapy with drugs such as mefloquine, piperaquine or the sulfadoxine/pyrimethamine combination. Nowadays, antimalarial therapy in endemic regions is more difficult to manage since the parasite has become resistant to most antimalarial drugs. 3,6 The resistance to artemisinin emerged in regions where this drug was used in a monotherapy protocol. 2,7 This situation continuously stimulates the search for new antimalarial drugs, especially from natural sources. 1de Souza et al. 1319 Vol. 29, No. 6, 2018 Plants showing proven antimalarial activity still represent a promising source of new medicines. It is important to note that some antimalarial drugs such as artemisinin and quinine have plant origin. 1,6,8 Poincianella pluviosa (DC.) L. P. Queiroz ...

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Section: Chemical Studymentioning

confidence: 57%

Section: Biological Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Leaves from the Tree Poincianella pluviosa as a Renewable Source of Antiplasmodial Compounds against Chloroquine-Resistant Plasmodium falciparum

Souza¹,

Nascimento²,

Borsodi³

et al. 2017

J. Braz. Chem. Soc.

View full text Add to dashboard Cite

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“…What's more, about 20% of the drugs used worldwide come from plants (Zengin, 2016). Tannins, phenolic acids, flavonoids, terpenoids, alkaloids and steroids are generally considered as the major bioactive constituents in plants (Bueno et al, 2014;Sousa et al, 2016;Zhang et al, 2016). Until now, enormous efforts have been performed to discover novel, safe and non-toxic plant sources or plant-derived natural compounds as alternative or complementary medicines for the treatment of various chronic diseases (Chang et al, 2016;Kumar et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Antihyperglycemic, antioxidant activities of two Acer palmatum cultivars, and identification of phenolics profile by UPLC-QTOF-MS/MS: New natural sources of functional constituents

Zhang

Xie

et al. 2016

Industrial Crops and Products

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“…Esto no ha sido ajeno al campo de la cicatrización de heridas, donde se buscan agentes que puedan acelerar este proceso mediante la estimulación de la proliferación y diferenciación celular incrementando los fibroblastos e inducción de la síntesis de colágeno (2) . El daño en la piel es generalmente asociado a procesos inflamatorios debido a lesiones agudas, como quemaduras, o lesiones crónicas como dermatitis atópica, acné vulgar o psoriasis (3) .…”

Section: Introductionunclassified

Efecto antiinflamatorio de la emulsión dermica del extracto etanólico de Peperomia choroniana D. CD. (ipitanki) en edema auricular inducido por xilol en ratones

Mayhuasca-Ysuhuaylas¹,

Arroyo-Acevedo²,

Franco-Quino³

2018

Rev. per. med. integr.

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Historia del artículo Información del artículo ResumenObjetivo. Evaluar el efecto antiinflamatorio de la emulsión dérmica del extracto etanólico de Peperomia choroniana en edema auricular inducido por xilol en ratones. Materiales y métodos. Estudio experimental. Se elaboró una emulsión dérmica del extracto etanólico de partes aéreas de Peperomia choroniana, la que se aplicó en ratones Swiss a quienes se les indujo inflamación con xilol. Se formaron seis grupos de seis ratones cada uno. El grupo I recibió crema base; el grupo II, dexametasona crema 0,05%; el grupo III, diclofenaco gel 1%; los grupos IV, V y VI, emulsión dérmica del extracto etanólico de Peperomia choroniana a las concentraciones de 0,1%, 0,5% y 1% respectivamente. Posterior a ello, se midieron los indicadores de edema auricular de ratones (Δpeso), inflamación cualitativa, temperatura auricular (ΔC°) y se realizó un estudio histopatológico. Resultados. Se encontró efecto antiinflamatorio en las emulsiones dermicas de Peperomia choroniana al 0,5% (54,6%) y al 1% (51,1%); asimismo, la emulsión dérmica al 0,5% redujo significativamente (p<0,05) la temperatura auricular (Δ3 °C). El estudio histopatológico mostró escaso infiltrado inflamatorio e incremento de fibroblastos en los grupos tratados con la emulsión a diferentes concentraciones. Conclusiones. La emulsión dérmica de Peperomia choroniana al 0,5% posee efecto antiinflamatorio tópico superior al diclofenaco gel 1%, pero inferior a la dexametasona crema 0,05% en la reducción de la inflamación y temperatura localizada. Palabras clave: Antiinflamatorios; Peperomia; Modelos animales; plantas medicinales (Fuente: DeCS).Anti-inflammatory effect of a dermal emulsion obtained from an ethanolic extract of Peperomia choroniana D. CD. (Ipitanki) on xylene-induced edema in mice AbstractObjective. To evaluate the anti-inflammatory effect of a dermal emulsion obtained from Peperomia choroniana ethanolic extract in xylene-induced ear edema in mice. Materials and Methods. An experimental study. Ear edema was induced with xylene in 36 Swiss mice, which were divided in six groups. Group I received basic cream; group II, dexamethasone cream 0.05%; Group III, diclofenac gel 1%; and Groups IV, V and VI received a dermal emulsion elaborated from an ethanolic extract of Peperomia choroniana aerial parts at concentrations of 0.1%, 0.5% and 1% respectively. After that, mouse ear edema (Δweight), qualitative inflammation and ear temperature (Δ°C) were measured and a histopathological study was developed. Results. An anti-inflammatory effect was founded on Peperomia choroniana dermal emulsions at 0.5% (54.6%) and 1% (51.1%); likewise, dermal emulsion at 0.5% significantly reduced handset temperature (Δ3 °C; p<0.05). The histopathological study showed a little inflammatory infiltrate and increased fibroblasts on treated groups at different concentrations. Conclusions. Peperomia choroniana dermal emulsion at 0.5% has more topical anti-inflammatory activity (reducing inflammation and localized temperature) than diclofenac ge...

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Hydrolyzable tannins from hydroalcoholic extract from Poincianella pluviosa stem bark and its wound-healing properties: Phytochemical investigations and influence on in vitro cell physiology of human keratinocytes and dermal fibroblasts

Cited by 51 publications

References 39 publications

Leaves from the Tree Poincianella pluviosa as a Renewable Source of Antiplasmodial Compounds against Chloroquine-Resistant Plasmodium falciparum

Leaves from the Tree Poincianella pluviosa as a Renewable Source of Antiplasmodial Compounds against Chloroquine-Resistant Plasmodium falciparum

Antihyperglycemic, antioxidant activities of two Acer palmatum cultivars, and identification of phenolics profile by UPLC-QTOF-MS/MS: New natural sources of functional constituents

Efecto antiinflamatorio de la emulsión dermica del extracto etanólico de Peperomia choroniana D. CD. (ipitanki) en edema auricular inducido por xilol en ratones

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