Hydrolyzed whey protein prevents the development of food allergy to β-lactoglobulin in sensitized mice

Gomes-Santos, Ana Cristina; Fonseca, Roberta Cristelli; Lemos, Luísa; Reis, Daniela Silva; Moreira, Thaís Garcias; Souza, Adna Luciana de; Silva, Mauro Ramalho; Silvestre, Marialice Pinto Coelho; Cara, Denise Carmona; Faria, Ana Maria Caetano

doi:10.1016/j.cellimm.2015.09.001

Cited by 30 publications

(17 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Food allergy induction was performed according to the model described by Gomes-Santos and coworkers ( Gomes-Santos et al, 2015 ). Briefly, mice were sensitized by intraperitoneal (i.p.)…”

Section: Methodsmentioning

confidence: 99%

“…Previous work showed that mice previously sensitized via intraperitoneal injection with a solution of BLG and Al(OH) 3 as adjuvant and posteriorly challenged by oral route with whey solution developed signs of food allergy similarly to those observed in OVA models, such as elevated levels of serum immunoglobulin (Ig) E, loss of body weight and eosinophilic inflammation ( Gomes-Santos et al, 2015 ).…”

Section: Introductionmentioning

confidence: 94%

See 1 more Smart Citation

Neuroimmune circuits involved in β-lactoglobulin-induced food allergy

Lemos

Assis

Alves

et al. 2022

Brain, Behavior, & Immunity - Health

Self Cite

View full text Add to dashboard Cite

“…Food allergy induction was performed according to the model described by Gomes-Santos and coworkers ( Gomes-Santos et al, 2015 ). Briefly, mice were sensitized by intraperitoneal (i.p.)…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

Neuroimmune circuits involved in β-lactoglobulin-induced food allergy

Lemos

Assis

Alves

et al. 2022

Brain, Behavior, & Immunity - Health

Self Cite

View full text Add to dashboard Cite

“…eHFs are well tolerated by most cow’s milk allergic infants. This is supported by animal studies showing that eHFs are suitable for CMA management, as they, in general, lack inherent allergenicity and do not induce clinical symptoms in cow’s milk allergic animals [ 153 , 167 ]. Yet, several human studies have shown reactivity towards eHFs in some cow’s milk allergic infants due to residual allergenicity still present even after extensive hydrolysis [ 8 , 166 , 168 , 169 ], indicating that eHF cannot be used for CMA management in all cow’s milk-allergic infants.…”

Section: Cow’s Milk-based Infant Formulasmentioning

confidence: 96%

Alternatives to Cow’s Milk-Based Infant Formulas in the Prevention and Management of Cow’s Milk Allergy

Maryniak

Sancho

Hansen

et al. 2022

Foods

View full text Add to dashboard Cite

Cow’s milk-based infant formulas are the most common substitute to mother’s milk in infancy when breastfeeding is impossible or insufficient, as cow’s milk is a globally available source of mammalian proteins with high nutritional value. However, cow’s milk allergy (CMA) is the most prevalent type of food allergy among infants, affecting up to 3.8% of small children. Hypoallergenic infant formulas based on hydrolysed cow’s milk proteins are commercially available for the management of CMA. Yet, there is a growing demand for more options for infant feeding, both in general but especially for the prevention and management of CMA. Milk from other mammalian sources than the cow, such as goat, sheep, camel, donkey, and horse, has received some attention in the last decade due to the different protein composition profile and protein amino acid sequences, resulting in a potentially low cross-reactivity with cow’s milk proteins. Recently, proteins from plant sources, such as potato, lentil, chickpeas, quinoa, in addition to soy and rice, have gained increased interest due to their climate friendly and vegan status as well as potential lower allergenicity. In this review, we provide an overview of current and potential future infant formulas and their relevance in CMA prevention and management.

show abstract

“…Food allergy was induced as previously described by Gomes-Santos (2015). Briefly, mice received intraperitoneally (i.p.)…”

Section: Mice Sensitization and Oral Challengementioning

confidence: 99%

“…To measure the concentration of anti-BLG IgE, capture-enzyme-linked immunosorbent assay (ELISA) was applied, in which plates coated with rat anti-mouse IgE was used, as previously described by our group (Gomes-Santos et al, 2015). Briefly, serum samples were obtained from all mice groups after the last oral antigen exposure.…”

Section: Measurement Of Serum Specific Anti-blg Antibodiesmentioning

confidence: 99%

Neuroimmune circuits involved in β-lactoglobulin-induced food allergy

Lemos

Assis

Alves

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Cow`s milk allergy is the most prevalent food allergy that usually begins early in life and β-lactoglobulin (BLG) is the milk component with the highest allergenicity. It has been described that ovalbumin (OVA)-induced food allergy in mice is associated with anxiety and aversive behavior. However, it is yet to be determined whether altered behavior is a general component of food allergy or whether it is specific for some types of allergens. Thus, we investigated behavioral and neuroimmune circuits triggered by allergic sensitization to BLG. We found a neuroimmune conflict between aversion and reward in a model of food allergy induced to BLG. Mice sensitized to BLG did not present aversive behavior when the allergen was used for sensitization and oral challenge. Mice allergic to BLG preferred to drink the allergen-containing solution over water even though they presented high levels of specific IgE, inflammatory cells in the intestinal mucosa and significant weight loss. When sensitized to OVA and orally challenged with the same antigen, mice had display neuron activation in the amygdala suggesting an anxiety-related sensation. On the other hand, OVA-sensitized mice showed preference to consume a mixture of BLG and OVA during oral challenge in spite of their aversion to OVA. Consumption of OVA-BLG solution was associated with neuron activation in the nucleus accumbens, suggesting a reward sensation. Thus, the aversive behavior observed in food allergy to OVA does not apply to all antigens and some allergens may induce preference rather than aversion. Our study provides new insights into the neuroimmune conflicts regarding preference and avoidance to a common antigen associated with food allergy.

show abstract

Hydrolyzed whey protein prevents the development of food allergy to β-lactoglobulin in sensitized mice

Cited by 30 publications

References 32 publications

Neuroimmune circuits involved in β-lactoglobulin-induced food allergy

Neuroimmune circuits involved in β-lactoglobulin-induced food allergy

Alternatives to Cow’s Milk-Based Infant Formulas in the Prevention and Management of Cow’s Milk Allergy

Neuroimmune circuits involved in β-lactoglobulin-induced food allergy

Contact Info

Product

Resources

About