Hydropersulfides (RSSH) attenuate doxorubicin-induced cardiotoxicity while boosting its anticancer action

β-Galactosidase-activated nitroxyl (HNO) donors provide insights into redox cross-talk in senescent cells

“…These reactive species possess antioxidant properties, including the ability to directly scavenge lipid peroxides, 30 and can activate crucial antioxidant pathways such as nuclear factor erythroid 2-related factor 2 (Nrf2) activation. 31 Moreover, our study revealed that prodrug 1 effectively reduced ROS in senescent cells, and this reduction was dependent on the presence of H 2 S. Overall, our study opens up new avenues for the development of innovative antioxidants that harness the redox cross-talk between H 2 S and HNO, holding promise for novel therapeutic interventions.…”

A near-infrared light-activated nanoprobe for simultaneous detection of hydrogen polysulfide and sulfur dioxide in myocardial ischemia–reperfusion injury

“…[11][12][13] Previous studies have shown that hydro-persuldes and persuldes play critical roles in protecting the heart from I/R injury and anthracycline-induced cardiotoxicity. [14][15][16][17] It is essential to monitor the level of H 2 S n in cardiac I/R, given that hydropersuldes and persuldes undergo metabolism to H 2 S n in vivo. 18 In addition, SO 2 is considered the fourth gaseous signaling molecule, which exhibits an integral role in the effective regulation of vasodilation and blood pressure, as well as an antioxidant.…”

Melatonin alleviates 3,3′,4,4′,5‐pentachlorobenzene induced colon injury by relieving oxidative stress

“…It has been shown that evodiamine can also promote the dissociation of Nrf2 into the nucleus, reduce the level of ROS and the occurrence of oxidative stress in grass carp hepatocytes, and restore the expression of antioxidant genes 23 . Pharoah, et al have shown that hydrogen sulfide can alleviate the surge of ROS induced by doxorubicin (DOX), activate Nrf2 dependent pathway, and enhance endogenous antioxidant defense 24 . What's more, transcriptome analysis, sequencing of Nrf2 binding DNA and Nrf2 gene knockout study found the role of Nrf2 beyond its antioxidant and detoxification effects, including tissue repair and remodeling, mitochondrial turnover, metabolic reprogramming and inhibition of proinflammatory cytokines 25 .…”

“…23 Pharoah, et al have shown that hydrogen sulfide can alleviate the surge of ROS induced by doxorubicin (DOX), activate Nrf2 dependent pathway, and enhance endogenous antioxidant defense. 24 What's more, transcriptome analysis, sequencing of Nrf2 binding DNA and Nrf2 gene knockout study found the role of Nrf2 beyond its antioxidant and detoxification effects, including tissue repair and remodeling, mitochondrial turnover, metabolic reprogramming and inhibition of proinflammatory cytokines. 25 Considering that oxidative damage is related to PCB126 toxicity, and Nrf2 is an important transcription factor that regulates cell oxidative stress response, we speculate that Nrf2 may participate in PCB126-induced oxidative stress damage.…”