Hydrophilic iron oxide nanoparticles probe the organization of biomimetic layers: electrochemical and spectroscopic evidence

Nieciecka, Dorota; Królikowska, Agata; Kijewska, Krystyna; Blanchard, G. J.; Krysiński, Paweł

doi:10.1016/j.electacta.2016.05.098

Cited by 9 publications

(4 citation statements)

References 39 publications

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“…3a, only the Raman active modes characteristic of a cubic spinel structure of ferrite Ni 0.5 Zn 0.5 Fe 2 O 4 are observed (Varshney et al 2011, Da Silva et al 2010). It resembles strongly the vibrational pattern observed for the previously studied, identical in terms of chemical composition, but citrate stabilized superparamagnetic iron oxide-based magnetic nanoparticles (Nieciecka et al 2016). In other words, Raman spectra of the bare SPIONs (here not shown) and after modification with sebacic acid (Fig.…”

Section: Resultssupporting

confidence: 85%

Physicochemical properties and in vitro cytotoxicity of iron oxide-based nanoparticles modified with antiangiogenic and antitumor peptide A7R

et al. 2017

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Superparamagnetic iron oxide-based nanoparticles (SPIONs) are promising carriers as targeted drug delivery vehicles, because they can be guided to their target with the help of an external magnetic field. Functionalization of nanoparticles’ surface with molecules, which bind with high affinity to receptors on target tissue significantly facilitates delivery of coated nanoparticles to their targeted site. Here, we demonstrate conjugation of an antiangiogenic and antitumor peptide ATWLPPR (A7R) to SPIONs modified with sebacic acid (SPIONs-SA). Successful conjugation was confirmed by various analytical techniques (FTIR, SERS, SEM-EDS, TEM, TGA). Cell cytotoxicity studies, against two cell lines (HUVEC and MDA-MB-231) indicated that SPIONs modified with A7R reduced HUVEC cell viability at concentrations higher than 0.01 mg Fe/mL, in comparison to cells that were exposed to either the nanoparticles modified with sebacic acid or A7R peptide solely, what might be partially caused by a process of internalization.Electronic supplementary materialThe online version of this article (doi:10.1007/s11051-017-3859-x) contains supplementary material, which is available to authorized users.

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Section: Resultssupporting

confidence: 85%

Physicochemical properties and in vitro cytotoxicity of iron oxide-based nanoparticles modified with antiangiogenic and antitumor peptide A7R

et al. 2017

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“…The first stage of the research was to investigate the effect of nanoparticles on the monolayer formation process [ 66 ].…”

Section: Resultsmentioning

confidence: 99%

Hybrid System for Local Drug Delivery and Magnetic Hyperthermia Based on SPIONs Loaded with Doxorubicin and Epirubicin

et al. 2021

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Cancer is one of the most common causes of death worldwide, thus new solutions in anticancer therapies are highly sought after. In this work, superparamagnetic iron oxide nanoparticles (SPIONs) conjugated with anticancer drugs are synthesized and investigated as potential magnetic drug nanocarriers for local drug delivery and mild magnetic hyperthermia. We have obtained a hybrid system loaded with holmium and anticancer drugs and thoroughly studied it with respect to the size, morphology, surface modifications and magnetic properties, and interactions with the model of biological membranes, cytotoxicity. We present that nanoparticles having a round shape and size 15 nm are successfully stabilized to avoid their agglomeration and modified with doxorubicin or epirubicin within a controlled way. The number of drugs loaded into the SPIONs was confirmed with thermogravimetry. The hybrid based on SPIONs was investigated in touch with model biological membranes within the Langmuir-Blodgett technique, and results show that modified SPION interacts effectively with them. Results obtained with magnetic hyperthermia and biological studies confirm the promising properties of the hybrid towards future cancer cell treatment.

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“…The presence of nanoparticles in the subphase does not cause significant changes in the structure/organization of the obtained biomimetic DOPC and cardiolipin monolayers within the whole range of surface pressures and concentrations of IONP@CA studied ( Figure 8 a–d). For each monolayer, C s −1 is about 80 to 104 mN/m, indicating that all monitored monolayers were characterized by a similar molecule ordering at the water/air interface [ 38 ].…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Characterization of Magnetic Drug Carriers Modified with Tb3+ Ions

et al. 2022

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The study aimed to synthesize and characterize the magnetic drug carrier modified with terbium (III) ions. The addition of terbium extends the possibilities of their applications for targeted anticancer radiotherapy as well as for imaging techniques using radioisotopes emitting β+, β−, α, and γ radiation. The synthesis of iron oxide nanoparticles stabilized with citrates using the co-precipitation method (IONP @ CA) was carried out during the experimental work. The obtained nanoparticles were used to synthesize a conjugate containing terbium ions and guanosine-5′-monophosphate as an analog of drugs from the thiopurine group. Conjugates and their components were characterized using Transmission Electron Microscopy, infrared spectroscopy, X-ray microanalysis, spectrofluorimetry, and thermogravimetric analysis. The hybrid was also investigated with Langmuir layers to check the interaction with analogs of biological membranes.

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Hydrophilic iron oxide nanoparticles probe the organization of biomimetic layers: electrochemical and spectroscopic evidence

Cited by 9 publications

References 39 publications

Physicochemical properties and in vitro cytotoxicity of iron oxide-based nanoparticles modified with antiangiogenic and antitumor peptide A7R

Physicochemical properties and in vitro cytotoxicity of iron oxide-based nanoparticles modified with antiangiogenic and antitumor peptide A7R

Hybrid System for Local Drug Delivery and Magnetic Hyperthermia Based on SPIONs Loaded with Doxorubicin and Epirubicin

Synthesis and Characterization of Magnetic Drug Carriers Modified with Tb3+ Ions

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