Hydrophilic Matrix Tablets for Oral Controlled Release

Timmins, Peter; Pygall, Samuel R.; Melia, Colin D.

doi:10.1007/978-1-4939-1519-4

Cited by 31 publications

(2 citation statements)

References 5 publications

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“…The effects of the polymer hydration are further associated with drug dissolution and diffusion effects, osmotic effects, etc. [1,2]. The result of these phenomena is responsible for macroscopic properties and the performance of the drug delivery system [3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

“…In the previous study, we proposed an integrated methodology to effectively evaluate multiple spatiotemporal aspects of matrix tablet hydration: (1) quantitative water distribution using Karl Fischer (KF) titration of precisely localized samples; (2) water-polymer interaction using spatially localized differential scanning calorimetry (DSC); (3) water distribution and its molecular mobility in hydrophilic polymeric matrix upon hydration with non-invasive MRI [30]. According to the described methodology, the assessment of water content and interaction with the matrix is feasible for any area of the hydrated tablet, regardless of the hydration time and the state of the polymer-gel, sol, wetted polymer, unhydrated material, etc.…”

Section: Introductionmentioning

confidence: 99%

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Hydration Patterns in Sodium Alginate Polymeric Matrix Tablets—The Result of Drug Substance Incorporation

et al. 2021

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The purpose was to show, using destructive/nondestructive methods, that the interplay between water, tablet structure, and composition determine the unique spatiotemporal hydration pattern of polymer-based matrices. The tablets containing a 1:1 w/w mixture of sodium alginate with salicylic acid (ALG/SA) or sodium salicylate (ALG/SNA) were studied using Karl Fischer titration, differential scanning calorimetry, X-ray microtomography, and magnetic resonance imaging. As the principal results, matrix specific features were detected, e.g., “locking” of the internal part of the matrix (ALG/SA); existence of lamellar region associated with detection of free/freezing water (ALG/SA); existence of water penetrating the matrix forming specific region preceding infiltration layer (ALG/SNA); switch in the onset temperature of endothermic water peak associated with an increase in the fraction of non-freezing water weight per dry matrix weight in the infiltration layer (ALG/SNA). The existence of complicated spatiotemporal hydration patterns influenced by matrix composition and molecular properties of constituents has been demonstrated.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hydration Patterns in Sodium Alginate Polymeric Matrix Tablets—The Result of Drug Substance Incorporation

et al. 2021

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Binding affinity and decontamination of dermal decontamination gel to model chemical warfare agent simulants

Cao

Elmahdy

Zhu

et al. 2018

J of Applied Toxicology

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Six chemical warfare agent simulants (trimethyl phosphate, dimethyl adipate, 2-chloroethyl methyl sulfide, diethyl adipate, chloroethyl phenyl sulfide and diethyl sebacate) were studied in in vitro human skin to explore relationship between dermal penetration/absorption and the mechanisms of simulant partitioning between stratum corneum (SC) and water as well as between dermal decontamination gel (DDGel) and water. Both binding affinity to and decontamination of simulants using DDGel were studied. Partition coefficients of six simulants between SC and water (Log P ) and between DDGel and water (Log P ) were determined. Results showed that DDGel has a similar or higher binding affinity to each simulant compared to SC. The relationship between Log P octanol/water and Log P as well as between Log P octanol/water and Log P demonstrated that partition coefficient of simulants correlated to their lipophilicity or hydrophilicity. Decontamination efficiency results with DDGel for these simulants were consistent with binding affinity results. Amounts of percentage dose of chemicals in DDGel of trimethyl phosphate, dimethyl adipate, 2-chloroethyl methyl sulfide, diethyl adipate, chloroethyl phenyl sulfide and diethyl sebacate were determined to be 61.15, 85.67, 75.91, 53.53, 89.89 and 76.58, with corresponding amounts absorbed in skin of 0.96, 0.65, 1.68, 0.72, 0.57 and 1.38, respectively. In vitro skin decontamination experiments coupled with a dermal absorption study demonstrated that DDGel can efficiently remove chemicals from skin surface, back-extract from the SC, and significantly reduced chemical penetration into skin or systemic absorption for all six simulants tested. Therefore, DDGel offers a great potential as a NextGen skin Decon platform technology for both military and civilian use.

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Binding Affinity and Decontamination of Dermal Decontamination Gel (DDGel) to Model Chemical Warfare Agent (CWA) Simulants

Cao¹,

Elmahdy²,

Zhu³

et al. 2019

Skin Decontamination

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Hydrophilic Matrix Tablets for Oral Controlled Release

Cited by 31 publications

References 5 publications

Hydration Patterns in Sodium Alginate Polymeric Matrix Tablets—The Result of Drug Substance Incorporation

Hydration Patterns in Sodium Alginate Polymeric Matrix Tablets—The Result of Drug Substance Incorporation

Binding affinity and decontamination of dermal decontamination gel to model chemical warfare agent simulants

Binding Affinity and Decontamination of Dermal Decontamination Gel (DDGel) to Model Chemical Warfare Agent (CWA) Simulants

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