Hydrophilic Modification Strategies to Enhance the Surface Biocompatibility of Poly(dimethylsiloxane)‐Based Biomaterials for Medical Applications

Sutthiwanjampa, Chanutchamon; Hong, Seungpyo; Kim, Woo Ju; Kang, Sung Ho; Park, Hansoo

doi:10.1002/admi.202202333

Cited by 24 publications

(10 citation statements)

References 234 publications

(343 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Various surface modification methods have been proposed to hydrophilize the surface of PDMS and reduce biofouling . However, the hydrophilic nature of the oxidized PDMS surface is usually temporary.…”

Section: Polymer Brushes: Grafting-from Approachmentioning

confidence: 99%

“…Various surface modification methods have been proposed to hydrophilize the surface of PDMS and reduce biofouling. 70 However, the hydrophilic nature of the oxidized PDMS surface is usually temporary. Hydrophobic recovery occurs when the high interfacial energy between the hydrophilic surface and hydrophobic air decreases; 71 the recovery mechanisms involve the reorientation of low molecular−weight species from the bulk to surface as well as conformational changes of molecules in the subsurface.…”

Section: ■ Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Photoassisted Surface Modification with Zwitterionic Phosphorylcholine Polymers for the Fabrication of Ideal Biointerfaces

Iwasaki

2023

Langmuir

View full text Add to dashboard Cite

Surface modification using zwitterionic 2-methacryloyloxyethyl phosphorylcholine (MPC) polymers is commonly performed to fabricate interfaces that reduce nonspecific fouling by biomolecules and cells. Accordingly, several clinically used devices, such as guide wires, stents, oxygenators, left ventricular assist devices, and microcatheters have been modified using MPC polymers. The specific types of surface modifications vary across substrates and applications. Recently, photoreactions have garnered attention for surface modification due to their stability and tunability. This review highlights various studies that employed photoreactions to modify surfaces using MPC polymers, especially photoinduced graft polymerization of MPC. In addition to antifouling materials, several micromanipulated, longlasting hydrophilic, and super antiwear surfaces are summarized. Furthermore, several photoreactive MPC polymers that can be used to control interactions between biomolecules and materials are presented along with their potential to form selective recognition surfaces that target biomolecules for biosensors and diagnostic devices.

show abstract

Section: Polymer Brushes: Grafting-from Approachmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Photoassisted Surface Modification with Zwitterionic Phosphorylcholine Polymers for the Fabrication of Ideal Biointerfaces

Iwasaki

2023

Langmuir

View full text Add to dashboard Cite

show abstract

“…20,21 Two primary strategies have been employed for this purpose: the construction of antifouling or bacteria-releasing surfaces to reduce bacterial numbers 22,23 and the fabrication of bactericidal surfaces to decrease bacterial viability. 24,25 Antifouling surfaces can be created through the introduction of hydrophilic compounds, 26,27 zwitterionic polymers, 28,29 superhydrophobic substances, 30,31 and slippery coatings 32,33 on the material surface, hindering bacterial adhesion. However, no material has thus far demonstrated complete resistance to adhesion.…”

Section: Introductionmentioning

confidence: 99%

Disruption of Communication: Recent Advances in Antibiofilm Materials with Anti-Quorum Sensing Properties

Qu,

Zou,

Wang

et al. 2024

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Biofilm contamination presents a significant threat to public health, the food industry, and aquatic/marine-related applications. In recent decades, although various methods have emerged to combat biofilm contamination, the intricate and persistent nature of biofilms makes complete eradication challenging. Therefore, innovative alternative solutions are imperative for addressing biofilm formation. Instead of solely focusing on the eradication of mature biofilms, strategically advantageous measures involve the delay or prevention of biofilm formation on surfaces. Quorum sensing, a communication system enabling bacteria to coordinate their behavior based on population density, plays a pivotal role in biofilm formation for numerous microbial species. Materials possessing antibiofilm properties that target quorum sensing have gained considerable attention for their potential to prevent biofilm formation. This Review consolidates recent research progress on the utilization of materials with antiquorum sensing properties for combating biofilm formation. These materials can be categorized into three distinct types: (i) antibiofilm nanomaterials, (ii) antibiofilm surfaces, and (iii) antibiofilm hydrogels with antiquorum sensing capabilities. Finally, the Review concludes with a brief discussion of current challenges and outlines potential avenues for future research.

show abstract

“…At this stage, researchers have been focused on the introduction of silicone-containing polymers with different structures and investigating their properties. , The properties of copolymers may have originated from PDMS’s low surface energy, which makes it enrich the surface of materials and form a diatom-like structure that endows the copolymer with unexpected combined properties and functions. The molecular weight of PDMS is a key parameter that affects its distribution in copolymers.…”

Section: Introductionmentioning

confidence: 99%

Copolymers Based on PBS and Polydimethylsiloxane with Improved Properties and Novel Functions: Effect of Molecular Weight of Polydimethylsiloxane

Zhou,

Wang,

Wang

et al. 2023

ACS Sustainable Chem. Eng.

View full text Add to dashboard Cite

The serious environmental pollution caused by nonbiodegradable plastics has led to an increased demand for biodegradable plastics. Poly(butylene succinate) (PBS) is a very essential biodegradable polymer because of its good combined properties. But its drawbacks of low impact strength and lack of functionality restrain its application. In this work, polydimethylsiloxane (PDMS) is used to synthesize the diatom-like structure poly(butylene succinate)-b-polydimethylsiloxane (PBSP), and the effect of molecular weight on the structure and properties is investigated systematically for the first time. The unique layered structure limited by the covalently connected blocks endowed PBSP with an excellent combined performance. The resulting PBSP possesses good thermal and mechanical properties. The mechanical properties improved substantially; especially, the impact strength increased evidently from 34.6 J/m of PBS to 162.5 J/m of PBSP. Furthermore, PDMS blocks endow the copolymers with good hydrophobicity and antismudge and self-healing properties, which greatly broadens the application range of the PBS materials. The surface analysis and Flory–Huggins solution theory testified that the PDMS blocks with higher molecular weight preferentially enriched the surface and sublayer of the material, due to the huge difference in solubility parameters between PBS and PDMS. PBSP with regulatable mechanical properties and functions could be obtained by changing the molecular weight of the PDMS blocks.

show abstract

Hydrophilic Modification Strategies to Enhance the Surface Biocompatibility of Poly(dimethylsiloxane)‐Based Biomaterials for Medical Applications

Abstract: (3 of 18)www.advmatinterfaces.de Figure 2. Long-term biofilm control via active topography. The programmed beating of micrometer-sized pillars propelled by a magnetic field can be adjusted to provide antifouling. [114,116] Reproduced with permission. [116] Copyright 2021, Elsevier.

Cited by 24 publications

References 234 publications

Photoassisted Surface Modification with Zwitterionic Phosphorylcholine Polymers for the Fabrication of Ideal Biointerfaces

Photoassisted Surface Modification with Zwitterionic Phosphorylcholine Polymers for the Fabrication of Ideal Biointerfaces

Disruption of Communication: Recent Advances in Antibiofilm Materials with Anti-Quorum Sensing Properties

Copolymers Based on PBS and Polydimethylsiloxane with Improved Properties and Novel Functions: Effect of Molecular Weight of Polydimethylsiloxane

Contact Info

Product

Resources

About