Hydrophilic PCU scaffolds prepared by grafting PEGMA and immobilizing gelatin to enhance cell adhesion and proliferation

Shi, Changcan; Yuan, Wenjie; Khan, Musammir; Li, Qian; Feng, Yakai; Yao, Fanglian; Zhang, Wencheng

doi:10.1016/j.msec.2015.02.015

Cited by 67 publications

(46 citation statements)

References 64 publications

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“…As thoroughly investigated in many other tissue engineering (TE) studies, gelatin displays excellent biocompatibility for enhancing cell adhesion and viability 38. Indeed, the application of a gelatin-based intermediary layer exerted a potent surface-refining effect on the iron oxide framework that was initially not very conducive to cell adhesion.…”

Section: Discussionmentioning

confidence: 99%

Implantable and Biodegradable Macroporous Iron Oxide Frameworks for Efficient Regeneration and Repair of Infracted Heart

et al. 2017

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The construction, characterization and surgical application of a multilayered iron oxide-based macroporous composite framework were reported in this study. The framework consisted of a highly porous iron oxide core, a gelatin-based hydrogel intermediary layer and a matrigel outer cover, which conferred a multitude of desirable properties including excellent biocompatibility, improved mechanical strength and controlled biodegradability. The large pore sizes and high extent of pore interconnectivity of the framework stimulated robust neovascularization and resulted in substantially better cell viability and proliferation as a result of improved transport efficiency for oxygen and nutrients. In addition, rat models with myocardial infraction showed sustained heart tissue regeneration over the infract region and significant improvement of cardiac functions following the surgical implantation of the framework. These results demonstrated that the current framework might hold great potential for cardiac repair in patients with myocardial infraction.

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Section: Discussionmentioning

confidence: 99%

Implantable and Biodegradable Macroporous Iron Oxide Frameworks for Efficient Regeneration and Repair of Infracted Heart

et al. 2017

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“…22 In our previous studies, several gene carriers to condense with pEGFP-ZNF580 gene (pEGFP-ZNF580 gene is the recombinant plasmid of enhanced GFP plasmid and ZNF580 gene) were prepared with different block copolymers for the proliferation of ECs. [23][24][25][26][27][28][29] As the "gold" standard nonviral gene carrier, polyethylenimine (PEI) is widely used as an effective gene carrier, which exhibits a good performance in condensing DNA due to its high positive charge density. 30 However, the drawbacks of high-molecular weight PEI, including nondegradability and high cytotoxicity, limit its application in vivo.…”

Section: Feng Et Almentioning

confidence: 99%

Co-self-assembly of cationic microparticles to deliver pEGFP-ZNF580 for promoting the transfection and migration of endothelial cells

Feng¹,

Guo²,

Li³

et al. 2016

IJN

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“…This relatively inexpensive inorganic polymerization process allows the use of low temperature during almost all stages of the reaction making possible the incorporation of different biomolecules. Hence, gelatin was also introduced into the siloxane network due to its well‐known biocompatibility and capacity to facilitate cell adhesion and proliferation …”

Section: Introductionmentioning

confidence: 99%

Enhancement of plasma protein adsorption and osteogenesis of hMSCs by functionalized siloxane coatings for titanium implants

et al. 2017

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A series of sol-gel derived silicon based coatings were developed to improve the osseointegration of commercial titanium dental implants. The osseointegration starts with a positive interaction between the implant surface and surrounding tissues, which is facilitated by the adsorption of plasma proteins onto the biomaterial surface immediately after implantation. It is likely that the enhancement of protein adsorption to titanium implants leads to a better implant/tissue integration. In addition, silica based biomaterials have been shown to promote osteoblast differentiation. To improve the protein adsorption and the osteogenesis, methyltrimethoxysilane (MTMOS), tetraethoxysilane (TEOS), 3-glycidoxypropyltrimethoxysilane (GPTMS), and gelatin were selected to coat titanium surfaces. Compared with non-coated titanium, the functionalized coatings enhanced the adsorption of adhesive proteins such as fibronectin and collagen. The Si release was successfully modulated by the control of the chemical composition of the coating, showing a higher dissolution rate with the gelatin and GPTMS incorporation. While the roughness of commercial implants seemed to promote the adhesion of mesenchymal stem cells (MSC), the osteogenic differentiation was greater on surfaces with Si-coatings. In this study, an improved osteogenic surface has been achieved by using the siloxane-gelatin coatings and such coatings can be used in dental implants to promote osseointegration. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1138-1147, 2018.

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Hydrophilic PCU scaffolds prepared by grafting PEGMA and immobilizing gelatin to enhance cell adhesion and proliferation

Cited by 67 publications

References 64 publications

Implantable and Biodegradable Macroporous Iron Oxide Frameworks for Efficient Regeneration and Repair of Infracted Heart

Implantable and Biodegradable Macroporous Iron Oxide Frameworks for Efficient Regeneration and Repair of Infracted Heart

Co-self-assembly of cationic microparticles to deliver pEGFP-ZNF580 for promoting the transfection and migration of endothelial cells

Enhancement of plasma protein adsorption and osteogenesis of hMSCs by functionalized siloxane coatings for titanium implants

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