Hydrophilic platinum complexes of N-2-hydroxyethyl- and N,N-di(2-hydroxyethyl)-N′-benzoylthiourea ligands. Crystal and molecular structure of N,N-di(2-hydroxyethyl)-N′-benzoythiourea

N-benzoyl-N′-alkylthioureas and their complexes with Ni(II), Co(III) and Pt(II) – crystal structure of 3-benzoyl-1-butyl-1-methyl-thiourea: activity against fungi and yeast

“…One specific use of these substances is the coordination of harmful elements, which can be achieved in the organism by one or several ligands of suitable structure. This is an important aspect and in future more attention should be devoted to the design and new agents able to coordinate these toxic metal ions to obtain complexes that can be readily eliminated from the organism [3,4]. The introduction of several substitutes into a given ligand can increase their selectivity to certain cations and permit their recognition by living organisms.…”

Crystal structure of N,N′-(1,6-hexamethylene)-bis(benzoylthiourea), C22H26N4O2S2

“…Ina 13 CNMR study, the differencesbetween the benzoyl (CO) chemicalshift value of N-monosubstituted and N,N-disubstituted indicated the existence of ani ntramolecularh ydrogen bond, namely between the benzoyl (CO)and the N-Hgroup. The indication wasalso supported by the 1 HNMR spectrum [10]. The crystalstructure of the title compound is only built up by the C 22H 26N 4 O 2 S 2 molecules.…”

Thiourea, triazole and thiadiazine compounds and their metal complexes as antifungal agents

“…The inhibition value of (26) (88.1%) was higher than the inhibition value of the ligand alone and of the other two complexes of N-ethylisopropylamine derivative; however, inhibition by (25), complexed with Co(III), was lower (63.6%) than that of the complexes of the same ligand with Ni(II) (80.3%) or Pt(II) (96.1%) and than the ligand alone (93.5%). The (27) complex of N-butylmethylamine derivative with Pt(II) had inhibition values of about 96% but the (28) complex did not show significant inhibition against P. digitatum. The data included in this table are taken from [3].…”

“…These modifications in the ligands are expected to enhance the solubility (hydrophobic/ hydrophilic) of the resulting compounds and to increase their potency as antifungals. In 2004, del Campo et al [19] reported on the synthesis, characterization and antifungal activity of thiourea derivatives of N-butylmethylamine (3-benzoyl-1-butyl-1-methyl-thiourea) (21), N-ethylisopropylamine (3-benzoyl-1-ethyl-1-isopropyl-thiourea) (22) and the corresponding complexes of (21 and 22) with Ni(II) (23,24), Co(III) (25,26) and Pt(II) (27,28) (see Scheme 2) against the fungus Penicillium digitatum and against the yeast Saccharomyces cerevisiae. Sensitivity to the compounds tested was found to be very different between both microorganisms.…”

“…One specific use of these substances is the coordination of harmful elements, which can be achieved in the organism by one or several ligands of suitable structure. In the future more attention should be devoted to the design of new agents able to coordinate these toxic metal ions to obtain complexes that can be readily eliminated from the organism [26,27]. The introduction of several substituents into a given ligand can increase the selectivity of the ligand to individual metal cations and result in their recognition by living organisms.…”