Hydrophilization of synthetic biodegradable polymer scaffolds for improved cell/tissue compatibility

Oh, Se Heang; Lee, Jin Ho

doi:10.1088/1748-6041/8/1/014101

Cited by 118 publications

(80 citation statements)

References 181 publications

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“…Based on previous studies, treatment with NaOH was anticipated to affect the surface chemistry of PCL by hydrolysis of the ester group, yielding materials displaying carboxylic acid and hydroxyl groups on their surfaces [30,40]. NaOH treatment of PCL resulted in an exposure time-dependent decrease in hydrophobicity, as demonstrated by the change in WCA measurements ( Fig.…”

Section: Naoh Treatment Of Pcl Decreases Wca Of Filmsmentioning

confidence: 96%

Conductive interpenetrating networks of polypyrrole and polycaprolactone encourage electrophysiological development of cardiac cells

et al. 2015

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Current conductive materials for use in cardiac regeneration are limited by cytotoxicity or cost in implementation. In this manuscript, we demonstrate for the first time the application of a biocompatible, conductive polypyrrole-polycaprolactone film as a platform for culturing cardiomyocytes for cardiac regeneration. This study shows that the novel conductive film is capable of enhancing cell-cell communication through the formation of connexin-43, leading to higher velocities for calcium wave propagation and reduced calcium transient durations among cultured cardiomyocyte monolayers. Furthermore, it was demonstrated that chemical modification of polycaprolactone through alkaline-mediated hydrolysis increased overall cardiomyocyte adhesion. The results of this study provide insight into how cardiomyocytes interact with conductive substrates and will inform future research efforts to enhance the functional properties of cardiomyocytes, which is critical for their use in pharmaceutical testing and cell therapy.

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Section: Naoh Treatment Of Pcl Decreases Wca Of Filmsmentioning

confidence: 96%

Conductive interpenetrating networks of polypyrrole and polycaprolactone encourage electrophysiological development of cardiac cells

et al. 2015

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“…The most commonly used degradable synthetic polymers are aliphatic polyesters such as polyglycolic acid or poly lactic acid co-glycolic acid [24]. However, most biodegradable polymers have questionable mechanical stability and stiffness [8,26].…”

Section: Introductionmentioning

confidence: 99%

In vivo degradation of magnesium alloy LA63 scaffolds for temporary stabilization of biological myocardial grafts in a swine model

Schilling¹,

Brandes²,

Tudorache

et al. 2013

Biomedizinische Technik/Biomedical Engineering

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Synthetic or biological patch materials used for surgical myocardial reconstruction are often fragile. Therefore, a transient support by degradable magnesium scaffolds can reduce the risk of dilation or rupture of the patch until physiological remodeling has led to a sufficient mechanical durability. However, there is evidence that magnesium implants can influence the growth and physiological behavior of the host's cells and tissue. Hence, we epicardially implanted scaffolds of the magnesium fluoride-coated magnesium alloy LA63 in a swine model to assess biocompatibility and degradation kinetics. Chemical analysis of the pigs' organs revealed no toxic accumulation of magnesium ions in the skeletal muscle, myocardium, liver, kidney, and bone of the pigs 1, 3, and 6 months postimplantation. The implants were surrounded by a fibrous granulation tissue, but no signs of necrosis were histologically evaluable. A sufficiently slow degradation rate of the magnesium alloy scaffold can be demonstrated via micro-computed tomography investigation. We conclude that stabilizing scaffolds of the magnesium fluoride-coated magnesium alloy LA63 can be used for epicardial application because no significant adverse effects to myocardial tissue were noted. Thus, degradable stabilizing scaffolds of this magnesium alloy with a slow degradation rate can extend the indication of innovative biological and synthetic patch materials.

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“…Likewise, tissue-engineered biodegradable materials with autologous cell seeding before patch repair, where a bioreactor culture system was used, have been well documented as potential cardiovascular patches (27)(28)(29)(30)(31)(32)(33). Oh and Lee reviewed hydrophilization of synthetic biodegradable polymeric scaffolds for improving cell/tissue compatibility (34). This technique has been considered a simple and effective approach to achieve desirable in vitro cell culture and in vivo tissue regeneration within the synthetic polymeric scaffolds.…”

Section: Cell-seeded Scaffoldsmentioning

confidence: 99%

Bioengineered Vascular Scaffolds: The State of the Art

et al. 2014

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To date, there is increasing clinical need for vascular substitutes due to accidents, malformations, and ischemic diseases. Over the years, many approaches have been developed to solve this problem, starting from autologous native vessels to artificial vascular grafts; unfortunately, none of these have provided the perfect vascular substitute. All have been burdened by various complications, including infection, thrombogenicity, calcification, foreign body reaction, lack of growth potential, late stenosis and occlusion from intimal hyperplasia, and pseudoaneurysm formation. In the last few years, vascular tissue engineering has emerged as one of the most promising approaches for producing mechanically competent vascular substitutes. Nanotechnologies have contributed their part, allowing extraordinarily biostable and biocompatible materials to be developed. Specifically, the use of electrospinning to manufacture conduits able to guarantee a stable flow of biological fluids and guide the formation of a new vessel has revolutionized the concept of the vascular substitute. The electrospinning technique allows extracellular matrix (ECM) to be mimicked with high fidelity, reproducing its porosity and complexity, and providing an environment suitable for cell growth. In the future, a better knowledge of ECM and the manufacture of new materials will allow us to “create” functional biological vessels - the base required to develop organ substitutes and eventually solve the problem of organ failure.

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Hydrophilization of synthetic biodegradable polymer scaffolds for improved cell/tissue compatibility

Cited by 118 publications

References 181 publications

Conductive interpenetrating networks of polypyrrole and polycaprolactone encourage electrophysiological development of cardiac cells

Conductive interpenetrating networks of polypyrrole and polycaprolactone encourage electrophysiological development of cardiac cells

In vivo degradation of magnesium alloy LA63 scaffolds for temporary stabilization of biological myocardial grafts in a swine model

Bioengineered Vascular Scaffolds: The State of the Art

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