Hydrophobic@amphiphilic hybrid nanostructure of iron-oxide and graphene quantum dot surfactant as a theranostic platform

Fateh, Sepand Tehrani; Kamalabadi, Mahdieh Ahmadi; Aliakbarniya, Azita; Jafarinejad-Farsangi, Saeideh; Koohi, Maedeh; Jafari, Elham; Karam, Zahra Miri; Keyhanfar, Fariborz; Dezfuli, Amin Shiralizadeh

doi:10.1016/j.onano.2022.100037

Cited by 4 publications

(2 citation statements)

References 20 publications

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“…Tehrani Fateh et al prepared hybrid nanoparticles (Nps) from cetyl alcohol‐modified GQDs and iron oxide magnetic nanoparticles having magnetic, photoluminescent, targeting, and drug‐loading properties. Cell viability tests were performed with the hybrid NPs in two types of noncancerous and one type of cancer cell lines and in vivo toxicity was investigated in mice liver and heart (Tehrani Fateh et al, 2022). Chen et al developed a drug delivery platform by coating Fe 3 O 4 nanoparticles with chitosan, loading the drug doxorubicin into the composite, and further modifying the drug‐loaded composite with GQDs and aptamers.…”

Section: Carbon Quantum Dots In Drug Deliverymentioning

confidence: 99%

“…The smaller nanoparticles were cleared by the kidneys, while larger moved towards liver for further processing. The prime destination for the degradation of administered nanoparticles was the liver, where they were rapidly degraded and cleared from the bloodstream through rapid uptake by the macrophages (Karimi & Namazi, 2020; Tehrani Fateh et al, 2022; Zhang et al, 2016). Tatiana Da Ros et al reported that nanoparticles with size less than 32 nanometers were able to pass renal ultrafiltration barrier and the GQDs/CQDs were cleared off through urine (Hadad et al, 2021).…”

Section: Carbon Quantum Dots In Drug Deliverymentioning

confidence: 99%

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Recent advances in biomedical applications of carbon and graphene quantum dots: A review

Das,

Roy,

Saha

2024

Biotech & Bioengineering

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The carbon‐based nanostructures have led to the development of theranostic nanoplatforms for simultaneous diagnosis and therapy due to their effective cell membrane‐penetration ability, low degree of cytotoxicity, excellent pore volume, substantial chemical stability, and reactive surface. In the last few years, extensive efforts were made to design multifunctional nanoplatform strategies based on carbon nanostructures, involving multimodal imaging, controlled drug release capabilities, sensing in vitro, efficient drug loading capacity, and therapy. Carbon and graphene quantum dots (CQDs and GQDs) were the recent entrants, contingently being assessed for drug delivery and bioimaging. With the advancements, these quantum dots have ignited remarkable research interest and are now widely evaluated for diagnosis, bioimaging, sensing, and drug delivery applications. The last decade has witnessed their remarkable electrical, optical, and biocompatible properties since their inception. It is presumed that both of them have high potential as drug carriers and would serve as the next generation of approaches to address numerous unresolved therapeutic challenges. This review examined the recent advances of CQD and GQD based drug delivery applications, challenges, and future perspectives to pave the way for further studies in the future.

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Section: Carbon Quantum Dots In Drug Deliverymentioning

confidence: 99%

Section: Carbon Quantum Dots In Drug Deliverymentioning

confidence: 99%

Recent advances in biomedical applications of carbon and graphene quantum dots: A review

Das,

Roy,

Saha

2024

Biotech & Bioengineering

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Commercial and regulatory challenges in cancer nanomedicine

Fateh,

Salehi-Najafabadi

et al. 2024

Functionalized Nanomaterials for Cancer Research

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Hybrid Quantum Dot as Promising Tools for Theranostic Application in Cancer

et al. 2023

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Cancer is one of the leading causes of death worldwide. In the last few decades, cancer treatment has come a long way, but multidrug resistance (MDR) in cancer still has low survival rates. It means that much research is required for an accurate diagnosis and effective therapy. The new era of cancer research could include theranostic approaches and targeted delivery of chemotherapeutic agents utilizing the nanoparticulate system. Recently, there has been much interest gained among researchers for carbon-based and graphene-based quantum dots due to their higher biocompatibility and ease of biofunctionalization compared to conventional heavy metal quantum dots. Moreover, these quantum dots have various interesting utilities, including bioimaging, biosensing, quantum dots-mediated drug delivery, and their role in photodynamic therapy (PDT) and photothermal therapy (PTT). The current review highlighted the utility of hybrid quantum dots as a theranostic system in different cancers and discussed the various bio-molecules conjugated hybrid quantum dots investigated for diagnostic/therapeutic applications in cancer. The influence of conjugation of different biomolecules, such as folic acid, PEG, etc., with hybrid quantum dots on their biopharmaceutical attributes (such as aqueous solubility, tumor penetrability, stability of loaded therapeutics in the tumor microenvironment), delivery of drugs specifically to tumor tissues, and its therapeutic outcome in different cancer has also been discussed.

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Hydrophobic@amphiphilic hybrid nanostructure of iron-oxide and graphene quantum dot surfactant as a theranostic platform

Cited by 4 publications

References 20 publications

Recent advances in biomedical applications of carbon and graphene quantum dots: A review

Recent advances in biomedical applications of carbon and graphene quantum dots: A review

Commercial and regulatory challenges in cancer nanomedicine

Hybrid Quantum Dot as Promising Tools for Theranostic Application in Cancer

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