Hydrophobic interaction mediated coating of pluronics on mesoporous silica nanoparticle with stimuli responsiveness for cancer therapy

Sha, Luping; Wang, Da; Mao, Yuling; Shi, Wei; Gao, Tianbin; Zhao, Qinfu; Wang, Siling

doi:10.1088/1361-6528/aac6b1

Cited by 18 publications

(9 citation statements)

References 30 publications

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“…492 This imbalance in GSH concentration has been exploited to design redox-responsive release systems and more particularly, redox-responsive MSNs for smart drug delivery. 130,136,303,348,493–503…”

Section: Potential Biomedical Treatments Using Msnsmentioning

confidence: 99%

Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades?

et al. 2022

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Section: Potential Biomedical Treatments Using Msnsmentioning

confidence: 99%

Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades?

et al. 2022

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“…The P123 bond breaks and separates from the surface of MSNs. [35] Lin et al designed redox responsive and synergistic dual delivery nanocarrier of DOX and p53 gene supported on MSNs using dendronized chitosan derivatives acted as a gatekeeper. The DOX was released in control amount under high concentration of glutathione in HeLa cancer cells.…”

Section: Redoxmentioning

confidence: 99%

“…The breakage of disulphide bonds was done by high concentrated glutathione, and hydrophobic chains become free. The P123 bond breaks and separates from the surface of MSNs [35] . Lin et al.…”

Section: Mechanism Of Drug Deliverymentioning

confidence: 99%

Nano‐Drug Carriers: A Potential Approach towards Drug Delivery Methods

et al. 2022

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Drugs are directly connected to the approaches by which they are administered and their delivery affects cellular uptake, biodistribution, toxicity, and excretion. Drug delivery methods are also necessary to be modified with the development of new therapeutic agents. This review summarizes the information about advancements in the field of drug delivery and mechanisms of drug action followed by factors affecting biocompatibility. Graphene, graphene oxide, mesoporous silica nanoparticles (MSNs), iron oxide nanoparticles, polyethylene glycol ligands and gold nanoparticles are prominent advancements in the field of drug delivery. These nanocarriers are engulfed by the cells through endocytosis followed by intracellular trafficking to reach the cytoplasm and their biocompatibility can be affected by various physicochemical parameters like surface charge, size, and shape. This review article may prove essential for the modification of drug delivery methods with the development of new therapeutic agents to eliminate the hurdles in near future.* Drug carrier should be physiologically active. * Visiting molecules security and loading should be high. * No drug release before reaching target point. * Cells should be capable of accepting drug agents efficiently. * There should be controlled release of drug agents at target point.In order to fulfill these conditions, various strategies had been planned to synthesize the drug delivery system. Liposome based nanoparticles, [7] dendrimers and polymer have been used for drug delivery operating under physical environment. [8] Recently inorganic nanoparticles based drug delivery and carbon nanotubes have opened a new area in this field. [9] Nanocarriers like gold, semiconductor nano crystal, silica based nanomaterials [10] are mostly researched and has become a promising candidate for this field. [11] Mesoporous silica nanoparticle having size less than 500 nm are very attractive as drug carrier because of pore volume, high surface area and changeable pore sizes. [12] They are being used as a vehicle for delivery of therapeutic agents. [13] Some gate-keepers are needed to trap the drug agents inside mesoporous silica nanoparticles surface. [14] Polydopamine is a good gate keeper for this purpose and has the capability to make different compatible materials like polymer, semiconductors and ceramics by personal polymerization of dopamine in hydrophilic solution. [15] This is a recognized gate keeper on mesoporous silica surface and is much sensitive towards pH. By covering surface with polydopamine, cargo is loaded at neutral pH and moves out at lower pH. [16] Bio-based substances are being utilized as an important element in DDS as they have the polysaccharide based nanocarriers which are dominating due to their low poisonous nature, constancy after loading the therapeutic agents and biodegradability. [17] Moreover, the use of polysaccharide based aerogel has been increasing in the medicinal industry because of lightweight material and good surface area. [18] DDS qualities are tune...

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“…Besides, grafting peptides containing hydrophobic / bulky components and targeting units through disulfide bonds provides on-demand drug release and selective recognition of cancer cells [135,196,336,337]. An additional strategy involves grafting stearic acid molecules using GSH-sensitive bonds because such molecules can directly close the mesopores through hydrophobic interactions among them [338]. Moreover, stearic acid can be employed to attach an amphiphilic targeting peptide thanks to their hydrophobic nature, providing both gatekeeping and targeting features [339].…”

Section: Polymers and Small Moleculesmentioning

confidence: 99%

Influence of the Surface Functionalization on the Fate and Performance of Mesoporous Silica Nanoparticles

Gisbert-Garzarán

Vallet‐Regí

2020

Nanomaterials

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Mesoporous silica nanoparticles have been broadly applied as drug delivery systems owing to their exquisite features, such as excellent textural properties or biocompatibility. However, there are various biological barriers that prevent their proper translation into the clinic, including: (1) lack of selectivity toward tumor tissues, (2) lack of selectivity for tumoral cells and (3) endosomal sequestration of the particles upon internalization. In addition, their open porous structure may lead to premature drug release, consequently affecting healthy tissues and decreasing the efficacy of the treatment. First, this review will provide a comprehensive and systematic overview of the different approximations that have been implemented into mesoporous silica nanoparticles to overcome each of such biological barriers. Afterward, the potential premature and non-specific drug release from these mesoporous nanocarriers will be addressed by introducing the concept of stimuli-responsive gatekeepers, which endow the particles with on-demand and localized drug delivery.

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Hydrophobic interaction mediated coating of pluronics on mesoporous silica nanoparticle with stimuli responsiveness for cancer therapy

Cited by 18 publications

References 30 publications

Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades?

Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades?

Nano‐Drug Carriers: A Potential Approach towards Drug Delivery Methods

Influence of the Surface Functionalization on the Fate and Performance of Mesoporous Silica Nanoparticles

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