Hydrostatic pressure under hypoxia facilitates fabrication of tissue-engineered vascular grafts derived from human vascular smooth muscle cells in vitro

Kojima, Tomoyuki; Nakamura, Takashi; Saito, Junichi; Hidaka, Yuko; Akimoto, Taisuke; Inoue, Hana; Chick, Christian Nanga; Usuki, Toyonobu; Kaneko, Makoto; Miyagi, Etsuko; Ishikawa, Yoshihiro; Yokoyama, Utako

doi:10.1016/j.actbio.2023.09.041

Cited by 3 publications

(1 citation statement)

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“…On another note, Kojima et al addressed the need for biologically compatible vascular grafts by exploring scaffoldless tissue engineering methods for fabricating functional vascular mimetics. By utilising hydrostatic pressurisation under hypoxia, the researchers aimed to promote the formation of multilayered tunica media from human VSMCs, offering a potential solution for producing scaffoldless human vascular grafts [201].…”

Section: Biomimicry In Bioreactor Design For Tissue Maturationmentioning

confidence: 99%

Biomimetic Approaches in Scaffold-Based Blood Vessel Tissue Engineering

Rosellini,

Giordano,

Guidi

et al. 2024

Biomimetics

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Cardiovascular diseases remain a leading cause of mortality globally, with atherosclerosis representing a significant pathological means, often leading to myocardial infarction. Coronary artery bypass surgery, a common procedure used to treat coronary artery disease, presents challenges due to the limited autologous tissue availability or the shortcomings of synthetic grafts. Consequently, there is a growing interest in tissue engineering approaches to develop vascular substitutes. This review offers an updated picture of the state of the art in vascular tissue engineering, emphasising the design of scaffolds and dynamic culture conditions following a biomimetic approach. By emulating native vessel properties and, in particular, by mimicking the three-layer structure of the vascular wall, tissue-engineered grafts can improve long-term patency and clinical outcomes. Furthermore, ongoing research focuses on enhancing biomimicry through innovative scaffold materials, surface functionalisation strategies, and the use of bioreactors mimicking the physiological microenvironment. Through a multidisciplinary lens, this review provides insight into the latest advancements and future directions of vascular tissue engineering, with particular reference to employing biomimicry to create systems capable of reproducing the structure–function relationships present in the arterial wall. Despite the existence of a gap between benchtop innovation and clinical translation, it appears that the biomimetic technologies developed to date demonstrate promising results in preventing vascular occlusion due to blood clotting under laboratory conditions and in preclinical studies. Therefore, a multifaceted biomimetic approach could represent a winning strategy to ensure the translation of vascular tissue engineering into clinical practice.

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Section: Biomimicry In Bioreactor Design For Tissue Maturationmentioning

confidence: 99%