Hydrosulfide-selective ChemFETs for aqueous H2S/HS− measurement

Abstract

We have prepared and characterized hydrosulfide-selective ChemFET devices based on a nitrile butadiene rubber membrane containing tetraoctylammonium nitrate as a chemical recognition element that is applied to commercially available field-effect transistors. The sensors have fast (120 s) reversible responses, selectivity over other biologically relevant thiol-containing species, detection limits of 8 mM, and a detection range from approximately 5 to 500 mM. Sensitivities are shown to be 53 mV per decade at pH 8. Use of this compact, benchtop sensor platform requires little training – only the ability to measure DC voltage, which can be accomplished with a conventional multimeter or a simple analog data acquisition device paired with a personal computer. To the best of our knowledge, this report describes the first example of direct potentiometric measurement of the hydrosulfide ion in water.

Benchmarking the placement of hydrosulfide in the Hofmeister series using a bambus[6]uril-based ChemFET sensor

“…Overview Hydrosulde (HS − ) is the conjugate base of the gasotransmitter hydrogen sulde (H 2 S), and is a physiologically-relevant small molecule of emerging interest in the anion sensing community. [1][2][3][4][5][6][7][8][9][10] The selective recognition and detection of HS − in water, however, remains difficult due to the diffuse charge and high solvation energy of anions in general, 4 as well as the high nucleophilicity and redox activity of HS − . 5 Different detection and quantication methods for H 2 S have been reported and typically rely on electrophilic trapping or reaction with activity-based probes to generate a uorescent response.…”

Novel H2S sensing mechanism derived from the formation of oligomeric sulfide capping the surface of gold nanourchins

“…The World Health Organization suggests that H 2 S gas concentrations should not exceed a 7 mg m −3 , average over a half hour period. [6][7][8][9] Various instrumental analysis methods such as ow injection analysis, 10 ion exchange chromatography (IC) 11 , electrochemical methods, [12][13][14] ultra-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS), 15,16 and uorometry 17 have been employed to analyze the concentration of H 2 S. However, these analytical techniques generally require the use of state-of-the-art analytical apparatus and laborious sample pre-treatment, and must be performed by well-trained experts. This has motivated the recent development of several original and innovative nanoparticle probes for H 2 S detection.…”

Evaluating impacts of bambusuril pocket size and sterics on anion binding trends using ChemFET sensors

“…2). [14][15][16] Incorporation of the supramolecular host into the gate oxide membrane facilitates direct measurement of hydrophobic host interaction with aqueous anion guests. In a ChemFET application, the differences between the more accessible binding pockets found in dodecabenzyl bambusuril and the less accessible central interior binding pocket of dodeca-n-butyl bambusuril are of particular interest (Fig.…”

“…17,18 The two bambusurils chosen were the previously characterized dodeca-n-butyl bambus [6]uril 16 and dodecabenzyl bambus [6]uril. 9,[12][13][14] These two bambusurils were chosen due to marked differences in sterics and anion binding pockets resulting from the different external substituents. Additionally, crystal structures of dodeca-n-butyl bambusuril showed that, like dodeca-n-propyl bambusuril, it was also cylindrical in shape and binds small anions in a 1 : 1 host-guest stoichiometry.…”

“…2). [14][15][16] A polyvinyl chloride (PVC)based membrane system was developed, with the PVC made semi-permeable by the inclusion of ortho-nitrophenyl octyl ether (NPOE) as plasticizer. Cationic character was imparted into the semi-permeable membrane by inclusion of tetraoctylammonium nitrate (TOAN).…”