Hydrotalcite catalysis for the synthesis of new chiral building blocks

Abstract

The use of hydrotalcites for the synthesis of two chiral building blocks in a simple way is described as a new and green methodology. The synthesis of these compounds implies a regioselective Baeyer-Villiger reaction in a very selective way with ulterior opening and lactonisation. This methodology should be considered green for the use of hydrogen peroxide as the only oxidant and hydrotalcites as the catalyst, and because no residues are produced apart from water. The procedure is very adequate for using in gram scale, in order to increase the value of the obtained compounds. The conditions are excellent and can be applied for nonstable compounds, as they are very mild. The synthesised compounds are magnific starting materials for the synthesis of biologically active or natural compounds. The use of a cheap, commercial and chiral compound as carvone disposable in both enantiomeric forms adds an extra value to this methodology.

Diastereoselective Synthesis of 7,8-Carvone Epoxides

“…An elevated number of chiral organocatalysts has been developed, where amines play an important role and comprise the main family of organocatalysts ( Figure 1). achieved by chemoenzymatic methods [23] or with hydrotalcites and hydrogen peroxide [24]. Another strategy has been afforded, using N-bromosuccinimide (NBS) in DMSO and ulterior addition of bases [25].…”

Thermal stability changing caused by chromium (iii) in the carbonated magnesium-aluminum hydrotalcite

“…However, the change in the type of trivalent cation has a greater effect on the adsorption capacity of the material, especially due to the charge imbalance of lamella caused by the substitution, but also by differences in chemical affinity, generally due to variations in the binding properties of the transition metal cations (Bolognini et al, 2002;Obalová et al, 2005;Rao et al, 1998;Rodilla et al, 2015;Zhou et al, 2016;Wu et al, 2008).…”

Antioxidant Activity of New Carvone Derivatives

“…Our group has tried to use different natural products such as sclareol [1][2][3] or enthalimic acid [4][5][6] as starting material for the synthesis of compounds with biological interest. In the last years, we have been involved in the synthesis of carvone derivatives that could be used as building blocks in organic chemistry as 2, see Figure 1, 7 or as antioxidants as (R)-carvone 1 and its chloro-derivative 3. 8 Several diseases are associated with oxidative stress caused by free radicals.…”