Burn injuries are considered, worldwide, one of the leading causes of injury, morbidity and mortality. Second-degree burns may affect patients: physically, socially and psychologically. The aim of the study is to identify the physical, social, and psychological needs of patients with second degree burns to suggest are habilitation program and follow up care that will improve quality of life after acute stage recovery. To achieve the aima descriptive research was undertaken. The study was conducted at the outpatient clinic of a burn unit, affiliated to a University hospital, in Cairo, Egypt. A convenience sample of 154 patients with second degree burns from both genders and aged 18 years old or above were the subjects of the study. Five tools were adopted for data collection: 1) An interview sheet, 2) Brief burn specific health scale (BSHS-B), 3)Self-esteem scale, 4) Body image and appearance scale, and 5) Social needs assessment. The results revealed that patients with second degree burns need physical, social, and psychological support to pass through the life-threatening experience. There is a highly statistically significant relation among bio-psychosocial needs for patents with second degree burn. Second degree burns affect patients' physical, psychological, and social well-being and preparation is needed to achieve a healthy recovery. The study recommends the implementation of a health awareness program to overcome the incidence of problems due to burns that might have a serious impact on the quality of life. A targeted rehabilitation program will enhance physical, psychological, and social adaptation as well as a healthy reintegration to the society.