In the framework of the European Soultz‐sous‐Forêts enhanced geothermal system (EGS) in Alsace, France, 20 years of scientific and preindustrial tests had to be performed before the site began production of electricity in 2008. Stimulation tests were designed to enhance the permeability because most of the numerous natural fractures that crosscut the granite body were sealed by secondary minerals that crystallized as an effect of the circulation of local hot brines. The deep‐seated granitic reservoir is located between 4,500 and 5,000 m depths. Hydraulic stimulations were conducted in the four deep wells (GPK1, GPK2, GPK3, and GPK4) inducing different microseismic event patterns, which cannot be explained by tectonic structures alone. In the present work, we provide a review of the hydraulic tests and reinterpret them in the light of mineralogical data obtained along the boreholes. A clear relationship appears between mineralogy (mainly clay and calcite content) and the petrophysical, mechanical, and hydraulic behaviors of the rock mass. High calcite contents are correlated with an abundance of clay minerals, low Young's modulus, low magnetic susceptibility, and variation in spectral gamma ray. Microearthquakes are generated in the fresh granite zones, while clay and calcite‐rich zones, linked with hydrothermal alteration, might behave aseismically during hydraulic stimulations. These findings highlight the importance of a detailed knowledge of the petrography of a reservoir to conduct an effective stimulation while keeping the seismic hazard at a minimum.